Biochemistry and physiology of gastrointestinal somatostatin

Digestive Diseases and Sciences - Tập 34 - Trang S5-S13 - 1989
Michael R. Lucey1, Tadataka Yamada1
1Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor

Tóm tắt

Somatostatin, a tetradecapeptide initially isolated from the ovine hypothalamus, is widely distributed throughout the gastrointestinal tract where it may act as a hormone, local chemical messenger, or neurotransmitter to elicit many physiological actions. Release of somatostatin from D cells in the gut is regulated by mechanisms that are both dependent on and independent of cAMP. In most cases somatostatin acts to inhibit the function of its target cells. It performs this action in part via pertussis-toxin-sensitive inhibitory guanine nucleotide-binding proteins that regulate adenylate cyclase activity. Other mechanisms may involve sites of action distal to intracellular second messenger systems.

Tài liệu tham khảo

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