Biochemistry and physiology of gastrointestinal somatostatin
Tóm tắt
Somatostatin, a tetradecapeptide initially isolated from the ovine hypothalamus, is widely distributed throughout the gastrointestinal tract where it may act as a hormone, local chemical messenger, or neurotransmitter to elicit many physiological actions. Release of somatostatin from D cells in the gut is regulated by mechanisms that are both dependent on and independent of cAMP. In most cases somatostatin acts to inhibit the function of its target cells. It performs this action in part via pertussis-toxin-sensitive inhibitory guanine nucleotide-binding proteins that regulate adenylate cyclase activity. Other mechanisms may involve sites of action distal to intracellular second messenger systems.
Tài liệu tham khảo
Krulich L, Dharival APS, McCann SM: Stimulatory and inhibitory effects of purified hypothalamic extracts in growth hormone release from rat pituitaryin vitro. Endocrinology 83:783–790, 1968
Brazeau P, Vale W, Burgus R, Ling N, Butcher M, Rivier J, Guillemin R: Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179:77–79, 1973
Brazeau P, Epelbaum S, Tannenbaum G, Rorstad O, Martin J: Somatostatin: Isolation, characterization, distribution, and blood determination. Metabolism 27(Suppl 1): 1133–1137, 1978
Arimura A, Sato H, Coy DH, Schally AV: Radioimmunoassay for GH-release inhibiting hormone. Proc Soc Exp Biol Med 148:784–789, 1975
Arimura A, Sato H, Dupont A, Nishi N, Schally A: Somatostatin: Abundance of immunoreactive hormone in rat stomach and pancreas. Science 189:1007–1009, 1975
Schally AV, Dupont A, Arimura A, Redding TW, Nishi N, Linthicum GL, Schlesinger DH: Isolation and structure of somatostatin from porcine hypothalami. Biochemistry 15:509–514, 1976
Noe B, Spiess J, Rivier J, Vale W: Isolation and characterization of somatostatin from anglerfish pancreatic islet. Endocrinology 105:1410–1414, 1979
Conlon JM: Isolation and structure of guinea pig gastric and pancreatic somatostatin. Life Sci 35:213–220, 1984
Andrews PC, Dixon JE: Isolation and structure of a peptide hormone predicted from a mRNA sequence and second somatostatin from the catfish pancreas. J Biol Chem 256:8267–8270, 1981
Takami M, Reeve J, Hawke D, Shively J, Basinger S, Yamada T: Purification of somatostatin from frog brain: Coisolation with retinal somatostatin-like immunoreactivity. J Neurochem 45:1869–1874, 1985
Pradayrol L, Jornvall J, Mutt V, Ribet A:N-terminally extended somatostatin: The primary structure of somatostatin-28. FEBS Lett 109:55–58, 1980
Hobart P, Crawford R, Shen L, Pictet R, Rutter W: Cloning and sequence analysis of cDNAs encoding two distinct somatostatin precursors found in the endocrine pancreas of anglerfish. Nature 288:137–141, 1980
Minth C, Taylor W, Magazin M, Tavianini M, Collier K, Weith HL, Dixon, J: The structure of cloned DNA complementary to catfish pancreatic somatostatin-14 messenger RNA. J Biol Chem 257:10372–10377, 1982
Goodman RH, Jacobs JW, Dee PC, Habener JF: Somatostatin-28 encoded in a cloned cDNA obtained from a rat medullary thyroid carcinoma. J Biol Chem 257:1156–1159, 1982
Shen LP, Pictet R, Rutter W: Human somatostatin I: Sequence of the cDNA. Proc Natl Acad Sci USA 79:4575–4579, 1982
Shen LP, Rutter W: Sequence of the human somatostatin I gene. Science 224:168–171, 1984
Montminy MR, Goodman RH, Horovitch SJ, Habener JF: Primary structure of the gene encoding rat preprosomatostatin. Proc Natl Acad Sci USA 81:3337–3340, 1984
Tavianini MA, Hayes TE, Magazin MD, Minth CD, Dixon JE: Isolation, characterization, and DNA sequence of the rat somatostatin gene. J Biol Chem 259:11798–11803, 1984
Fujita T, Kobayashi S: The cells and hormones of the GEP endocrine system—the current of studies.In Gastroenteropancreatic Endocrine System. A Cell-Biological Approach. T Fujita (ed). Tokyo, Igaku Shoin 1973, pp 1–16
Kusumoto Y, Iwanaga T, Ito S, Fujita T: Juxtaposition of somatostatin cell and parietal cell in the dog stomach. Arch Histol Jpn 42:459–465, 1979
Larsson LI: Distribution and morphology of somatostatin cells.In Somatostatin. YC Patel, GS Tannebaum (eds). New York, Plenum, 1985, pp 383–402
Larsson LI, Goltermann N, Demagistris L, Rehfeld JF, Schwartz TW: Somatostatin cell processes as pathways for paracrine secretion. Science 205:1393–1395, 1979
Costa M, Patel Y, Furness JB, Arimura A: Evidence that some intrinsic neurons of the intestine contain somatostatin. Neurosci Lett 6:215–222, 1977
Vinik AI, Gaginella TS, O'Dorisio TM, Shapiro B, Wagner L: The distribution and characterization of somatostatin-like immunoreactivity in epithelial cells, submucosa, and muscle of the rat stomach and intestine. Endocrinology 19:1921–1926, 1981
Baldissera FGA, Holst JJ, Jensen SL, Krarup T: Distribution and molecular forms of peptides containing somatostatin immunodeterminants in extracts from the entire gastrointestinal tract of man and pig. Biochim Biophys Acta 838:132–143, 1985
Chayvialle JA, Miyata M, Rayford PL, Thompson JC: Immunoreactive somatostatin and vasoactive intestinal peptide in the digestive tract of cats. Gastroenterology 79:837–843, 1980
Penman E, Wass JAH, Butler MG, Penny ES, Price J, Wu P, Rees LH: The distribution and characterization of immunoreactive somatostatin in human gastrointestinal tract. Regulatory Peptides 7:53–65, 1983
Trent DF, GC Weir: Heterogeneity of somatostatin-like peptides in rat brain, pancreas, and gastrointestinal tract. Endocrinology 108:2033–2037, 1981
Chayvialle JA, Rayford PL, Thompson JC: Radioimmunoassay study of hepatic clearance and disappearance half-time of somatostatin and vasoactive intestinal peptide in dogs. Gut 22:732–737, 1981
Patel YC, Wheatley T:In vivo andin vitro plasma disappearance and metabolism of somatostatin-28 and somatostatin-14 in the rat. Endocrinology 112:220–225, 1983
Polonsky K, Jaspan J, Berelowitz M, Pugh W, Moossa A, Ling N: Thein vivo metabolism of somatostatin 28: Possible relationship between diminished metabolism and enhanced biological action. Endocrinology 111:1698–1703, 1982
Schusdziarra V, Harris V, Unger RH: Half-life of somatostatin-like immunoreactivity in canine plasma. Endocrinology 104:109–110, 1979
Seal A, Yamada T, Debas H, Hollinshead J, Osadchey B, Aponte G, Walsh J: Somatostatin-14 and -28: Clearance and potency on gastric function in dogs. Am J Physiol (Gastrointest Liver Physiol 6) 243:G97-G102, 1982
Sheppard M, Shapiro B, Pimstone B, Kronheim S, Berelowitz M, Gregory M: Metabolic clearance and plasma halfdisappearance time of exogenous somatostatin in man. J Clin Endocrinol Metab 48:50–52, 1979
Vaysse N, Chayvialle JA, Pradayrol L, Esteve JP, Susini C, Lapuelle J, Descos F, Ribet A: Somatostatin 28: Comparison with somatostatin 14 for plasma kinetics and low-dose effects on the exocrine pancreas in dogs. Gastroenterology 81:700–706, 1981
Conlon JM, Whittaker J, Hammond V, Alberti K: Metabolism of somatostatin and its analogues by the liver. Biochim Biophys Acta 677:234–242, 1981
Sacks H, Terry LC: Clearance of immunoreactive somatostatin by perfused rat liver. J Clin Invest 67:419–429, 1981
Taborsky G, Ensinck J: Extraction of somatostatin by the pancreas. Endocrinology 112:303–307, 1983
Ruggere MD, Patel Y: Somatostatin metabolism by the isolated rat lung. Endocrinology 117:1870–1873, 1985
Polonsky KS, Jaspan JB, Berelowitz M, Emmanouel DS, Dhorajiwala J: Hepatic and renal metabolism of somatostatin-like immunoreactivity. J Clin Invest 68:1149–1157, 1981
Pardridge WM, Eisenberg J, Yamada T: Rapid sequestration and degradation of somatostatin analogues by isolated brain microvessels. J Neurochem 44:1178–1184, 1985
Weber M, Cole T, Conlon JM: Specific binding and degradation of somatostatin by membrane vesicles from pig gut. Am J Physiol (Gastrointest Liver Physiol 13) 250:G679-G685, 1986
Chiayvialle JA, Miyata M, Rayford PL, Thompson JC: Effects of test meal, intragastric nutrients, and intraduodenal bile on plasma concentrations of immunoreactive somatostatin and vasoactive intestinal peptide in dogs. Gastroenterology 79:844–852, 1980
Colturi TM, Unger RJ, Feldman M: Role of circulation somatostatin in regulation of gastric acid secretion, gastrin release, and islet cell function. Studies in healthy subjects and duodenal ulcer patients. J Clin Invest 74:417–423, 1984
Penman E, Wass JAH, Medbak S, Morgan L, Lewis JM, Besser GM, Rees LH: Response of circulating immunoreactive somatostatin to nutritional stimuli in normal subjects. Gastroenterology 81:692–699, 1981
Polonsky KS, Shoelson SE, Docherty HM: Plasma somatostatin-28 increases in response to feeding in man. J Clin Invest 71:1514–1518, 1983
Schusdziarra V, Harris V, Conlon JM, Arimura A, Unger RH: Pancreatic and gastric somatostatin release in response to intragastric and intraduodenal nutrients and HCl in the dog. J Clin Invest 62:508–518, 1978
Taborsky GJ, Ensinck JW: Contribution of the pancreas to circulating somatostatin-like immunoreactivity in the normal dog. J Clin Invest 73:216–233, 1984
Gustavsson S, Lundquist G: Participation of antral somatostatin in the local regulation of gastrin release. Acta Endocrinol 88:339–346, 1978
Holst JJ, Jensen SL, Knuhtsen S, Nielsen OV, Rehfeld JF: Effect of vagus, gastric inhibitory polypeptide, and HCl on gastrin and somatostatin release from perfused pig antrum. Am J Physiol (Gastrointest Liver Physiol 7) 244:G515-G522, 1983
Lucey MR, Wass JAH, Fairclough PD, O'Hare M, Kwasowski P, Penman E, Webb J, Rees LH: Does gastric acid release plasma somatostatin in man? Gut 25:1217–1220, 1984
Guzman S, Chayvialle JA, Banks WA, Rayford PL, Thompson JC: Effects of vagal stimulation on pancreatic secretion and on blood levels of gastrin, cholecystokinin, secretion, vasoactive intestinal peptide, and somatostatin. Surgery 86:329–336, 1979
Lucey MR, Wass JAH, Fairclough P, Webb J, Webb S, Medbak S, Rees LH: Autonomic regulation of postprandial plasma somatostatin, gastrin and insulin. Gut 26:683–688, 1985
Uvnas-Wallensten K, Efendic S, Roovete A, Johansson C: Decreased release of somatostatin into the portal vein following electrical vagal stimulation in the cat. Acta Physiol Scand 109:393–398, 1980
Martindale R, Kauffman GL, Levin S, Walsh JH, Yamada T: Differential regulation of gastrin and somatostatin secretion from isolated perfused rat stomachs. Gastroenterology 93:240–244, 1982
McIntosh C, Pederson RA, Koop H, Brown JC: Gastric inhibitory polypeptide stimulated secretion of somatostatin-like immunoreactivity from the stomach: Inhibition by acetylcholine or vagal stimulation. Can J Physiol Pharmacol 59: 468–472, 1980
Saffouri B, Weir GC, Bitar KN, Makhlouf GM: Gastrin and somatostatin secretion by perfused rat stomach: Functional Linkage of antral peptides. Am J Physiol (Gastrointest Liver Physiol 1) 238:G495-G501, 1980
Sue R, Toomey ML, Todisco A, Soll AH, Yamada T: Pirenzepine-sensitive muscarinic receptors regulate gastric somatostatin and gastrin. Am J Physiol (Gastrointest Liver Physiol 11) 248:G184-G187, 1985
Soll AH, Yamada T, Park J, Thomas LP: Release of somatostatin-like immunoreactivity from canine fundic mucosal cells in primary culture. Am J Physiol (Gastrointest Liver Physiol 10) 247:G558-G566, 1984
Yamada T, Soll AH, Park J, Elashoff J: Autonomic regulation of somatostatin release: Studies with primary cultures of canine fundic mucosal cells. Am J Physiol (Gastrointest Liver Physiol 10) 247:G567-G573, 1984
Soll AH, Amirian DA, Park J, Elashoff JD, Yamada T: Cholecystokinin potently releases somatostatin from canine fundic mucosal cells in short-term culture. Am J Physiol (Gastrointest Liver Physiol 11) 248:G569-G573, 1985
Sugano K, Park J, Soll A, Yamada T: Phorbol esters stimulate somatostatin release from cultured cells. Am J Physiol (Gastrointest Liver Physiol 13) 250:G686-G690, 1986
Chiba T, Sugano K, Park J, Yamada T: Potential mediation of somatostatin secretion from canine fundic D-cells by protein kinase C. Am J Physiol 253:G52-G57, 1987
Chiba T, Raffoul K, Yamada T: Divergent stimulatory and inhibitory actions of carbamoylcholine on gastric D-cells. J Biol Chem 262:8467–8469, 1987
Chiba T, Yamada T: Mechanisms for the stimulatory and inhibitory effects of carbamoylcholine on canine gastric D-cells. Biochem Biophys Res Commun 147:140–144, 1987
Yamada T, Chiba T: Somatostatin.In Handbook of Physiology, Section on Neuroendocrinology of the Gut. G Makhlouf (ed). Bethesda, Maryland, 1988 (in press)
Seal AM, Meloche RM, Liu WE, Buchan AMJ, Brown JC: Effects of monoclonal antibodies to somatostatin on somatostatin-induced and intestinal fat-induced inhibition of gastric acid secretion in the rat. Gastroenterology 92:1187–1192, 1987
Short GM, Doyle JW, Wolfe MM: Effect of antibodies to somatostatin on acid secretion and gastrin release by the isolated perfused rat stomach. Gastroenterology 88:984–988, 1985
Park J, Chiba T, Yamada T: Mechanisms for direct inhibition of canine gastric parietal cells by somatostatin. J Biol Chem 262:14190–14196, 1987
Chew CS: Inhibitory action of somatostatin on isolated gastric glands and parietal cells. Am J Physiol (Gastrointest Liver Physiol 8) 245:G221-G229, 1983
Yajima Y, Akita Y, Saito T: Pertussis toxin blocks the inhibitory effects of somatostatin on cAMP-dependent vasoactive intestinal peptide and cAMP-independent thyrotropin releasing hormone-stimulated prolactin secretion of GH3 cells. J Biol Chem 261:2684–2689, 1986
Reyl FJ, Lewin MJM: Intracellular receptor for somatostatin in gastric mucosal cells: Decomposition and reconstitution of somatostatin-stimulated phosphoprotein phosphatases. Proc Natl Acad Sci USA 79:978–982, 1982
Hierowski MT, Leibow C, Sapin K, Schally AV: Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa-2 cell line. FEBS Lett 179:252–256, 1985
Green R, Shields D: Somatostatin discriminates between the intracellular pathways of secretory and membrane proteins. J Cell Biol 99:97–104, 1984