Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets

Passlick, 1989, Identification and characterization of a novel monocyte subpopulation in human peripheral blood., Blood, 74, 2527, 10.1182/blood.V74.7.2527.2527 Gordon, 2005, Monocyte and macrophage heterogeneity., Nat Rev Immunol, 5, 953, 10.1038/nri1733 Frankenberger, 1996, Differential cytokine expression in human blood monocyte subpopulations: a polymerase chain reaction analysis., Blood, 87, 373, 10.1182/blood.V87.1.373.373 Ancuta, 2003, Fractalkine preferentially mediates arrest and migration of CD16+ monocytes., J Exp Med, 197, 1701, 10.1084/jem.20022156 Geissmann, 2003, Blood monocytes consist of two principal subsets with distinct migratory properties., Immunity, 19, 71, 10.1016/S1074-7613(03)00174-2 Ziegler-Heitbrock, 2007, The CD14+ CD16+ blood monocytes: their role in infection and inflammation., J Leukoc Biol, 81, 584, 10.1189/jlb.0806510 Tacke, 2006, Migratory fate and differentiation of blood monocyte subsets., Immunobiology, 211, 609, 10.1016/j.imbio.2006.05.025 Auffray, 2009, Blood monocytes: development, heterogeneity, and relationship with dendritic cells., Annu Rev Immunol, 27, 669, 10.1146/annurev.immunol.021908.132557 Cros, 2010, Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors., Immunity, 33, 375, 10.1016/j.immuni.2010.08.012 Skrzeczynska-Moncznik, 2008, Peripheral blood CD14high CD16+ monocytes are main producers of IL-10., Scand J Immunol, 67, 152, 10.1111/j.1365-3083.2007.02051.x Schakel, 2002, 6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells., Immunity, 17, 289, 10.1016/S1074-7613(02)00393-X de Baey, 2001, Phenotype and function of human dendritic cells derived from M-DC8(+) monocytes., Eur J Immunol, 31, 1646, 10.1002/1521-4141(200106)31:6<1646::AID-IMMU1646>3.0.CO;2-X Grage-Griebenow, 2001, Heterogeneity of human peripheral blood monocyte subsets., J Leukoc Biol, 69, 11, 10.1189/jlb.69.1.11 Grage-Griebenow, 2001, Identification of a novel dendritic cell-like subset of CD64(+)/CD16(+) blood monocytes., Eur J Immunol, 31, 48, 10.1002/1521-4141(200101)31:1<48::AID-IMMU48>3.0.CO;2-5 Moniuszko, 2009, Enhanced frequencies of CD14++CD16+, but not CD14+CD16+, peripheral blood monocytes in severe asthmatic patients., Clin Immunol, 130, 338, 10.1016/j.clim.2008.09.011 Ziegler-Heitbrock, 2010, Nomenclature of monocytes and dendritic cells in blood., Blood, 116, e74, 10.1182/blood-2010-02-258558 Ziegler-Heitbrock, 1996, Heterogeneity of human blood monocytes: the CD14+ CD16+ subpopulation., Immunol Today, 17, 424, 10.1016/0167-5699(96)10029-3 Weiner, 1994, Phase I trial of recombinant macrophage colony-stimulating factor and recombinant gamma-interferon: toxicity, monocytosis, and clinical effects., Cancer Res, 54, 4084 Ancuta, 2009, Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocytes., BMC Genomics, 10, 403, 10.1186/1471-2164-10-403 Belge, 2002, The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF., J Immunol, 168, 3536, 10.4049/jimmunol.168.7.3536 Ingersoll, 2010, Comparison of gene expression profiles between human and mouse monocyte subsets., Blood, 115, e10, 10.1182/blood-2009-07-235028 Kim, 2010, Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage., J Leukoc Biol, 87, 557, 10.1189/jlb.0209082 Wong, 2008, On the necessity of different statistical treatment for Illumina BeadChip and Affymetrix GeneChip data and its significance for biological interpretation., Biol Direct, 3, 23, 10.1186/1745-6150-3-23 da Huang, 2009, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources., Nat Protoc, 4, 44, 10.1038/nprot.2008.211 Roth, 2003, Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules., Trends Immunol, 24, 155, 10.1016/S1471-4906(03)00062-0 Nobes, 1999, Rho GTPases control polarity, protrusion, and adhesion during cell movement., J Cell Biol, 144, 1235, 10.1083/jcb.144.6.1235 May, 2001, Phagocytosis and the actin cytoskeleton., J Cell Sci, 114, 1061, 10.1242/jcs.114.6.1061 Buttitta, 2007, Mechanisms controlling cell cycle exit upon terminal differentiation., Curr Opin Cell Biol, 19, 697, 10.1016/j.ceb.2007.10.004 Zhao, 2010, The CD14(+/low)CD16(+) monocyte subset is more susceptible to spontaneous and oxidant-induced apoptosis than the CD14(+)CD16(−) subset., Cell Death Dis, 1, e95, 10.1038/cddis.2010.69 Ziegler-Heitbrock, 1993, The novel subset of CD14+/CD16+ blood monocytes exhibits features of tissue macrophages., Eur J Immunol, 23, 2053, 10.1002/eji.1830230902 Chinenov, 2001, Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity., Oncogene, 20, 2438, 10.1038/sj.onc.1204385 Ubeda, 1999, CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins., Mol Cell Biol, 19, 7589, 10.1128/MCB.19.11.7589 Echlin, 2000, B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos., Oncogene, 19, 1752, 10.1038/sj.onc.1203491 Johnson, 2005, Molecular stop signs: regulation of cell-cycle arrest by C/EBP transcription factors., J Cell Sci, 118, 2545, 10.1242/jcs.02459 Laslo, 2006, Multilineage transcriptional priming and determination of alternate hematopoietic cell fates., Cell, 126, 755, 10.1016/j.cell.2006.06.052 van der Horst, 2007, Stressing the role of FoxO proteins in lifespan and disease., Nat Rev Mol Cell Biol, 8, 440, 10.1038/nrm2190 Klappacher, 2002, An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation., Cell, 109, 169, 10.1016/S0092-8674(02)00714-6 Robinson, 2006, Myeloid C-type lectins in innate immunity., Nat Immunol, 7, 1258, 10.1038/ni1417 Peiser, 2002, Scavenger receptors in innate immunity., Curr Opin Immunol, 14, 123, 10.1016/S0952-7915(01)00307-7 Zhao, 2009, Identification of novel functional differences in monocyte subsets using proteomic and transcriptomic methods., J Proteome Res, 8, 4028, 10.1021/pr900364p Mobley, 2007, Genetic evidence of a functional monocyte dichotomy., Inflammation, 30, 189, 10.1007/s10753-007-9036-0 Power, 2004, Bacterial lipoprotein delays apoptosis in human neutrophils through inhibition of caspase-3 activity: regulatory roles for CD14 and TLR-2., J Immunol, 173, 5229, 10.4049/jimmunol.173.8.5229 Tsutsumi-Ishii, 2003, Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine production., J Immunol, 170, 4226, 10.4049/jimmunol.170.8.4226 Craig, 2008, Flow cytometric immunophenotyping for hematologic neoplasms., Blood, 111, 3941, 10.1182/blood-2007-11-120535 Gorczyca, 2004, Flow cytometry immunophenotypic characteristics of monocytic population in acute monocytic leukemia (AML-M5), acute myelomonocytic leukemia (AML-M4), and chronic myelomonocytic leukemia (CMML)., Methods Cell Biol, 75, 665, 10.1016/S0091-679X(04)75028-1 Maynadie, 2002, Immunophenotypic clustering of myelodysplastic syndromes., Blood, 100, 2349, 10.1182/blood-2002-01-0230 Lacronique-Gazaille, 2007, A simple method for detection of major phenotypic abnormalities in myelodysplastic syndromes: expression of CD56 in CMML., Haematologica, 92, 859, 10.3324/haematol.11118 Xu, 2005, Flow cytometric analysis of monocytes as a tool for distinguishing chronic myelomonocytic leukemia from reactive monocytosis., Am J Clin Pathol, 124, 799, 10.1309/HRJ1XKTD77J1UTFM Lin, 2011, Immunosuppressive CD14+HLA-DR(low)/- monocytes in B-cell nonHodgkin lymphoma., Blood, 117, 872, 10.1182/blood-2010-05-283820 Ellery, 2007, The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo., J Immunol, 178, 6581, 10.4049/jimmunol.178.10.6581