Long-term survival and T-cell kinetics in relapsed/refractory ALL patients who achieved MRD response after blinatumomab treatment

Blood - Tập 126 - Trang 2578-2584 - 2015
Gerhard Zugmaier1, Nicola Gökbuget2, Matthias Klinger1, Andreas Viardot3, Matthias Stelljes4, Svenja Neumann5, Heinz-A. Horst5, Reinhard Marks6, Christoph Faul7, Helmut Diedrich8, Albrecht Reichle9, Monika Brüggemann5, Chris Holland10, Margit Schmidt1, Hermann Einsele11, Ralf C. Bargou12, Max S. Topp11
1Amgen Research (Munich), Munich, Germany;
2Department of Medicine II, Goethe University Frankfurt, Frankfurt, Germany
3Department of Internal Medicine III, University Hospital Ulm, Ulm, Germany
4Department of Medicine A, University of Münster, Münster, Germany;
5Department of Medicine II, Christian-Albrechts-Universität zu Kiel, Kiel, Germany;
6Department of Medicine I, Albert-Ludwigs-Universität Frieburg, Freiburg, Germany;
7Department of Medicine II, Eberhard Karls Universität Tübingen, Tübingen, Germany;
8Department of Hematology and Oncology, Medizinische Hochschule Hannover, Hannover, Germany
9Department of Medicine III, University of Regensburg, Regensburg, Germany;
10Amgen, Rockville, MD; and
11Department of Medicine II and
12Comprehensive Cancer Center Mainfranken, Universitätsklinikum Würzburg, Würzburg, Germany

Tóm tắt

Key Points Ten of 36 patients (28%) achieved an OS ≥30 months in a blinatumomab study in relapsed/refractory acute lymphoblastic leukemia. Long-term survival may be associated with T-cell expansion, B-cell depletion, and a minimal residual disease response.

Tài liệu tham khảo

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