Is Guillain-Barrè syndrome triggered by SARS-CoV-2? Case report and literature review

Neurological Sciences - Tập 42 - Trang 607-612 - 2020
Edoardo Agosti1, Andrea Giorgianni2, Francesco D’Amore2, Gabriele Vinacci3, Sergio Balbi1, Davide Locatelli1
1Division of Neurosurgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy
2Department of Neuroradiology, ASST Sette Laghi, University of Insubria, Varese, Italy
3Department of Radiology, University of Insubria, Varese, Italy

Tóm tắt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the infectious agent responsible for coronavirus disease 2019 (COVID-19). Respiratory and gastrointestinal manifestations of SARS-CoV-2 are well described, less defined is the clinical neurological spectrum of COVID-19. We reported a case of COVID-19 patient with acute monophasic Guillain-Barré syndrome (GBS), and a literature review on the SARS-CoV-2 and GBS etiological correlation. A 68 years-old man presented to the emergency department with symptoms of acute progressive symmetric ascending flaccid tetraparesis. Oropharyngeal swab for SARS-CoV-2 tested positive. Neurological examination showed bifacial nerve palsy and distal muscular weakness of lower limbs. The cerebrospinal fluid assessment showed an albuminocytologic dissociation. Electrophysiological studies showed delayed distal latencies and absent F waves in early course. A diagnosis of Acute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP) subtype of GBS was then made. Neurological manifestations of COVID-19 are still under study. The case we described of GBS in COVID-19 patient adds to those already reported in the literature, in support of SARS-CoV-2 triggers GBS. COVID-19 associated neurological clinic should probably be seen not as a corollary of classic respiratory and gastrointestinal symptoms, but as SARS-CoV-2-related standalone clinical entities. To date, it is essential for all Specialists, clinicians and surgeons, to direct attention towards the study of this virus, to better clarify the spectrum of its neurological manifestations.

Tài liệu tham khảo

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