Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors

Blood - Tập 127 - Trang 938-947 - 2016
Abraham S. Kanate1, Alberto Mussetti2, Mohamed A. Kharfan-Dabaja3, Kwang W. Ahn4,5, Alyssa DiGilio4, Amer Beitinjaneh6, Saurabh Chhabra7, Timothy S. Fenske8, Cesar Freytes9, Robert Peter Gale10, Siddhartha Ganguly11, Mark Hertzberg12, Evgeny Klyuchnikov13, Hillard M. Lazarus14, Richard Olsson15,16, Miguel-Angel Perales17, Andrew Rezvani18, Marcie Riches19, Ayman Saad20, Shimon Slavin21
1Osborn Hematopoietic Malignancy and Transplantation Program, West Virginia University, Morgantown, WV
2S.C. Ematologia e Trapianto di Midollo Osseo, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale dei Tumori, Milan, Italy;
3Department of Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL
4Center for International Blood and Marrow Transplant Research, Department of Medicine and
5Division of Biostatistics, Institute for Health and Society, Medical College of Wisconsin, Milwaukee, WI
6Division of Hematology/Oncology, Department of Medicine, Emily Couric Clinical Cancer Center, Charlottesville, VA;
7Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC;
8Department of Hematology/Oncology, Froedtert Memorial Lutheran Hospital, Milwaukee, WI;
9South Texas Veterans Health Care System and University of Texas Health Science Center San Antonio, San Antonio, TX;
10Hematology Research Centre, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, United Kingdom
11Blood and Marrow Transplantation, Division of Hematology and Oncology, University of Kansas Medical Center, Kansas City, KS;
12Department of Haematology, Prince of Wales Hospital, Randwick, NSW, Australia
13Department for Stem Cell Transplantation, University Cancer Center, Hamburg, Germany;
14Seidman Cancer Center, University Hospitals Case Medical Center, Cleveland, OH
15Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
16Centre for Clinical Research Sormland, Uppsala University, Uppsala, Sweden
17Adult Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY;
18Blood and Marrow Transplantation, Stanford University Medical Center, Stanford, CA
19Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC;
20Division of Hematology/Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL;
21The International Center for Cell Therapy & Cancer Immunotherapy, Tel Aviv, Israel;

Tóm tắt

Key Points Risk of grade III-IV acute and chronic GVHD is significantly lower with haploidentical compared with URD transplantation. Relapse risk, NRM, PFS, and OS was similar in haploidentical transplants compared with unrelated donor transplants.

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