Serum IL-33 Is Elevated in Children with Asthma and Is Associated with Disease Severity

International Archives of Allergy and Immunology - Tập 168 Số 3 - Trang 193-196 - 2015
Sedigheh Bahrami Mahneh1, Masoud Movahedi2, Zahra Aryan3, Mohammad Ali Bahar4, Arezou Rezaei5, Maryam Sadr3, Nima Rezaei1
1Department of Immunology, School of Medicine,
2Pediatrics Center of Excellence and
3Students' Scientific Research Center, Tehran University of Medical Sciences, and
4Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
5Research Center for Immunodeficiencies, Children's Medical Center Hospital, and

Tóm tắt

<b><i>Background:</i></b> The role of IL-33, a member of the IL-1 family, in airway hyperresponsiveness and asthma has still to be fully understood. <b><i>Objectives</i></b>: This study is aimed at investigating serum IL-33 in children with asthma and its association with asthma severity. <b><i>Methods:</i></b> This age- and sex-matched case-control study comprised 61 children with asthma and 63 healthy controls. The mean age of the participants was 9.21 years (range: 6-14). Serum IL-33 was measured using ELISA and was compared between children with asthma and controls. In addition, the association of serum IL-33 with asthma severity was investigated. <b><i>Results:</i></b> The level of serum IL-33 was significantly higher in children with asthma than in controls (15.17 ± 32.3 vs. 0.61 ± 2.16 pg/ml; p = 0.028). It was significantly increased proportionately to asthma severity, namely 9.92 ± 30.26 pg/ml in children with mild asthma, 13.68 ± 29.27 pg/ml in children with moderate asthma and 31.92 ± 41.45 pg/ml in children with severe asthma (p = 0.026). <b><i>Conclusion:</i></b> Serum IL-33 is increased in children with asthma and is associated with disease severity.

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International Archives of Allergy and Immunology

Tập 168 Số 3

193-196

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