Gerhard Levy1, Robert A. O’Reilly1, Paul M. Aggeler1, Geraldine M. Keech1
1Department of Pharmaceutics, School of Pharmacy, State University of New York at Buffalo, Department of Medicine, Santa Clara Valley Medical Center and Institute for Medical Research of Santa Clara County, and Department of Medicine, University of California School of Medicine
Tóm tắt
Pretreatment with heptabarbital has no effect on prothrombin complex activity before warfarin administration and does not affect the apparent first‐order rate constant for prothrombin complex activity degradation and the relationship between plasma warfarin concentration and prothrombin complex activity synthesis rate. The decreased response to warfarin during barbiturate administration is therefore due only to the inductive effect of the barbiturate on the warfarin‐metabolizing enzyme system. There is no evidence that barbiturate affects the distribution of warfarin in the body, the inherent activity of the blood coagulation process, or the response of the appropriate receptor to warfarin.
