On an enzymatic reaction between amino acids and nucleic acid and its possible role in protein synthesis

Wiley - Tập 77 Số 7 - Trang 623-633 - 1958
Mahlon B. Hoagland1,2
1The John Collins Warren Laboratories of the Huntington Memorial Hospital of Harvard University, at the Massachusetts General Hospital, Boston, Mass., U.S.A.
2Cavendish Laboratory, Cambridge University

Tóm tắt

AbstractEvidence has been presented which contributes more detail to our picture of the likely intermediate steps in the synthesis of protein. Thus it would appear that, following activation of animo acids by ATP and specific enzymes, there occurs a transfer of the activated animo acid from adenylamino acid to RNA‐amino acid. The RNA‐amino acid then appears to become associated with the microsomal ribonucleoprotein particles through the intermediation of guanosine triphosphate, with resultant condensation of amino acids to form protein. This scheme is a working hypothesis, and the present paper calls attention to some of the areas where more rigorous proof of the suggested reactions is required.

Từ khóa


Tài liệu tham khảo

Brachet J., 1955, The Nucleic Acids, New York, 2, 476

H.Borsook Proceedings of the Third International Congress of Biochemistry Brussels 1955 Academic Press New York (1956).

Loftfield R. B., Progress in Biophysics and Biochemistry

F. H. C.Crick Soc. Expl. Biol. Symposium(1957) (in press).

H.Chantrenne Ann. Rev. of Biochem.1958(in press).

10.1016/0006-3002(57)90175-0

10.1016/S0021-9258(19)77302-5

M. B.Hoagland P. C.ZamecnikandM. L.Stephenson Current Activities in Molecular Biology (in press).

10.1016/S0021-9258(18)65561-9

Borsook H., 1950, J. Biol. Chem., 187, 839, 10.1016/S0021-9258(18)56230-X

10.1016/0014-4827(50)90015-2

Keller E. B., 1951, Federation Proc, 10, 206

Tyner E. P., 1952, Cancer Research, 12, 158

10.1177/2.5.378

Doudoroff M., 1947, J. Biol. Chem., 168, 725, 10.1016/S0021-9258(17)30931-6

F.Lipmann inA Symposium on the Mechanism of Enzyme Action (ed. by Wm. D. McElroy and B. Glass) Baltimore (1954).

W.Maas Third International Congress of Biochemistry Brussels (1955).

10.1016/S0021-9258(18)65898-3

10.1073/pnas.42.6.325

Berg P., 1957, Federation Proc., 16, 152

10.1016/0006-3002(57)90081-1

10.1016/S0021-9258(18)65227-5

10.1016/S0021-9258(19)57162-9

10.1083/jcb.2.2.171

10.1042/bj0650307

10.1016/S0021-9258(18)65006-9

10.1016/0003-9861(57)90488-5

10.1021/ja01560a040

10.1016/0006-3002(56)90337-7

10.1016/0006-3002(57)90455-9

Zamecnik P. C., 1957, Federation Proc., 16, 275

A.Todd andD. M.Brown personal communication.

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Wiley

Tập 77 Số 7

623-633

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