ADCON®-L: a review of its development, mechanism of action, and preclinical data
Tóm tắt
ADCON®-L Anti-Adhesion Barrier Gel is a resorbable gel that is placed into the site of a laminectomy before surgical closure and acts as a barrier to scar and surgical adhesions. The scientific rationale for ADCON products is based on certain properties of glial cells and the nature and role of the basal lamina. ADCON-L was evaluated in laminectomy models using rats and rabbits and a discectomy model in dogs. In all studies, ADCON-L was an effective barrier to peridural scar and surgical adhesions.
Tài liệu tham khảo
Ahmad S. Coker GT, Silver J, Wujek J (1992) ADCON®-L is a potent and long acting inhibitor of surgical adhesions. J Invest Surg 5:247
Einhaus SL, Robertson JT, Wujek JR, Ahmad S (1993) Reduction of peridural fibrosis after lumbar laminectomy and discectomy in dogs by a carbohydrate polymer gel (ADCON-L) (abstract). Presented at the Annual Meeting of the American Association of Neurological Surgeons, Boston, MA, April 24–29, 1993
Hilton DL Jr, Robertson JT, Meric AL, Wujek J, Ahmad S (1992) Reduction of postlaminectomy epidural fibrosis in dogs by a carbohydrate polymer (abstract). Presented at the Southern Neurosurgical Society Meeting, Washington, DC, April 2–5, 1992
Reier PJ, Houle JD (1988) The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair. Adv Neurol 47:87–138
Robertson JT, Meric AL, Dohan FC Jr, Schweitzer JB, Wujek JR, Ahmad S (1993) The reduction of postlaminectomy peridural fibrosis in rabbits by a carbohydrate polymer. J Neurosurg 79:89–95
Snow DW, Lemmon V, Carrino DA, Caplan AI, Silver J (1990) Sulfated proteoglycans in astroglial barriers inhibit neurite growth in vitro. Exper Neurol 109:111–130
Wujek JR, Ahmad S, Harel A, Maier KH, Roufa D, Silver J (1991) A carbohydrate polymer that effectively prevents epidural fibrosis at laminectomy sites in the rat. Exper Neurol 114:237–245
Yong-Hing K, Reilly J, de Korompay V, Kirkaldy-Willis WH (1980) Prevention of nerve root adhesions after laminectomy. Spine 5:59–64