The Role of Orphan Nuclear Receptors in the Regulation of Cholesterol Homeostasis

Annual Review of Cell and Developmental Biology - Tập 16 Số 1 - Trang 459-481 - 2000
Joyce J. Repa1, David J. Mangelsdorf1
1Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9050

Tóm tắt

▪ Abstract  Cholesterol balance is maintained by a series of regulatory pathways that control the acquisition of cholesterol from endogenous and exogenous sources and the elimination of cholesterol, facilitated by its conversion to bile acids. Over the past decade, investigators have discovered that a family of membrane-bound transcription factors, sterol regulatory element-binding proteins (SREBPs), mediate the end-product repression of key enzymes of cholesterol biosynthesis. Recently orphan members of another family of transcription factors, the nuclear hormone receptors, have been found to regulate key pathways in bile acid metabolism, thereby controlling cholesterol elimination. The study of these orphan nuclear receptors suggests their potential as targets for new drug therapies.

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Annual Review of Cell and Developmental Biology

Tập 16 Số 1

459-481

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