Formation of the COOH‐terminal amide group of thyrotropin‐releasing‐factor

FEBS Letters - Tập 152 - Trang 277-281 - 1983
Intisar Husain1, Suresh S. Tate1
1Department of Biochemistry, Cornell University Medical College, New York, NY 10021 USA

Tóm tắt

The precursors of peptide hormones that possess a COOH‐terminal α‐amide group contain a glycine residue following the amino acid which is amidated in the hormone. 〈Glu—His—Pro—Gly was synthesized as a putative precursor of thyroliberin. Bovine pituitary neurosecretory granules were shown to contain an amide group‐forming activity associated with an M r of about 62000 protein(s) which converts the tetrapeptide to thyroliberin.

Tài liệu tham khảo

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FEBS Letters

Tập 152

277-281

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