Supraoptic Neurosecretory Cells: Adrenergic and Cholinergic Sensitivity

American Association for the Advancement of Science (AAAS) - Tập 171 Số 3967 - Trang 208-210 - 1971
Jeffery L. Barker1, John W. Crayton1, Roger A. Nicoll1
1Laboratory of Neuropharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington, D.C. 20032

Tóm tắt

Adrenergic and cholinergic agonists and antagonists were applied microelectrophoretically to over 700 neurons in the cat supraoptic nucleus, 20 percent of which were antidromically identified as neurosecretory cells. Norepinephrine uniformly depressed all sensitive cells. Acetylcholine caused both muscarinic depression and nicotinic excitation which were antagonized by atropine and dihydro-β-erythroidine, respectively. These results support the hypothesis that norepinephrine and acetylcholine are directly involved in controlling the release of antidiuretic hormone.

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American Association for the Advancement of Science (AAAS)

Tập 171 Số 3967

208-210

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