Lida Lotfi‐Dizaji1, Soltanali Mahboob2, Soodabeh Aliashrafi1, Elnaz Vaghef‐Mehrabany1, Mehrangiz Ebrahimi‐Mameghani3, Ashti Morovati1
1Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
2Nutritional Biochemistry, School of Nutrition and Food Sciences Tabriz University of Medical Sciences Tabriz Iran
3Nutrition Research Center, Faculty of Nutrition & Food Sciences Tabriz University of Medical Sciences Tabriz Iran
Tóm tắt
AbstractBackground & AimsLow serum 25‐hydroxyvitamin D (25OHD) is common in obese people. Obesity is associated with a state of low‐grade inflammation (meta‐inflammation). There is an increasing evidence indicating that vitamin D has anti‐adipogenic activity and immunoregulatory effect. This study aimed to assess the effect of vitamin D supplementation on meta‐inflammation and fat mass in obese subjects with vitamin D deficiency.Materials and methodsIn this double‐blind placebo‐controlled randomized clinical trial, 44 obese subjects with vitamin D deficiency (25OHD < 50 nmol/L) were assigned into vitamin D (a weight reduction diet + bolus weekly dose of 50 000 IU vitamin D) or placebo group (weight reduction diet + edible paraffin weekly) for 12 weeks. Weight, fat mass and serum levels of 25OHD, calcium, parathyroid hormone (PTH), monocyte chemoattractant protein‐1 (MCP‐1), interleukin‐1β (IL‐1β) and Toll‐like receptor 4 (TLR4) were assessed before and after the intervention.ResultsVitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP‐1 (P < 0.05), IL‐1β (P < 0.05) and TLR‐4 (P < 0.05); compared to the baseline values in vitamin D group. Weight, BMI and fat mass decreased in both groups (P < 0.05). Between the groups, there were significant decrease in weight, fat mass, serum MCP‐1 and PTH concentrations and significant increase in serum 25OHD concentrations after intervention with vitamin D supplementation compared to placebo (P < 0.05).ConclusionsImprovement in vitamin D status in obese subjects with vitamin D deficiency in combination with weight loss diet resulted in weight, fat mass and MCP‐1 decrease. Weight loss and vitamin D supplementation may act synergistically to reduce levels of meta‐inflammation.
