Michael Wegmann1, Harald Renz1, Udo Herz
1Department of Clinical Chemistry and Molecular Diagnostics, Hospital of the Philipps University of Marburg, Marburg, Germany
Tóm tắt
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, development of emphysema and irreversible airway obstruction. Macrophages, neutrophils and CD8+ T cells and their products have been shown to play an important role in the initiation and maintenance of these processes. In contrast, the mechanisms underlying COPD pathogenesis still remain uncertain. This article focuses on the generation of an animal model that mirrors some features of human COPD in association with a progredient airflow limitation.
