Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

Springer Science and Business Media LLC - Tập 63 - Trang 364-374 - 2020
Yingxia Liu1, Yang Yang1, Cong Zhang2,3, Fengming Huang3, Fuxiang Wang1, Jing Yuan1, Zhaoqin Wang1, Jinxiu Li1, Jianming Li1, Cheng Feng1, Zheng Zhang1, Lifei Wang1, Ling Peng1, Li Chen1, Yuhao Qin3, Dandan Zhao3, Shuguang Tan4, Lu Yin5, Jun Xu5, Congzhao Zhou2, Chengyu Jiang3, Lei Liu1
1Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China
2Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China
3State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Department of Biochemistry, Peking Union Medical College, Beijing, China
4Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
5Emergence Department Peking Union Medical College Hospital, Beijing, China

Tóm tắt

The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. Here we report the epidemiological, clinical, laboratory, and radiological characteristics, as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen, China. All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). The most common laboratory abnormalities were hypoalbuminemia, lymphopenia, decreased percentage of lymphocytes (LYM) and neutrophils (NEU), elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH), and decreased CD8 count. The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity. ALB, LYM, LYM (%), LDH, NEU (%), and CRP were highly correlated to the acute lung injury. Age, viral load, lung injury score, and blood biochemistry indexes, albumin (ALB), CRP, LDH, LYM (%), LYM, and NEU (%), may be predictors of disease severity. Moreover, the Angiotensin II level in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury. Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection.

Tài liệu tham khảo

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