Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients

American Association for the Advancement of Science (AAAS) - Tập 359 Số 6371 - Trang 97-103 - 2018
Vancheswaran Gopalakrishnan1, Christine N. Spencer1, Luigi Nezi1, Alexandre Reuben1, Miles C. Andrews1, Tatiana V. Karpinets1, Peter A. Prieto1, Diego Vicente1, Kristi L. Hoffman2, Spencer C. Wei2, Alexandria P. Cogdill1, Li Zhao1, Courtney W. Hudgens1, Diane S. Hutchinson3, Teresa Manzo1, Mariana Petaccia de Macêdo1, Tiziana Cotechini4, Tapsi Kumar1, W. S. Chen1, Sangeetha M. Reddy5, Robert Szczepaniak‐Sloane1, Jessica Galloway-Peña1, Hong Jiang1, P. L. Chen1, Elizabeth J. Shpall1, Katayoun Rezvani1, Amin M. Alousi1, Roy F. Chemaly1, Samuel A. Shelburne1, Luis M. Vence1, Pablo C. Okhuysen1, V. Behrana Jensen1, Alton G. Swennes3, Florencia McAllister1, Erick Riquelme1, Yexi Zhang1, Emmanuelle Le Chatelier6, Laurence Zitvogel7,8, Nicolas Pons6, Jacob L. Austin-Breneman1, Lauren E. Haydu1, Elizabeth M. Burton1, Julie M. Gardner1, Elizabeth Sirmans9, Jiemiao Hu9, Alexander J. Lazar1, Takahiro Tsujikawa4, Adi Diab9, Hussein A. Tawbi9, Isabella C. Glitza9, Wen-Jen Hwu9, Sapna P. Patel9, Scott E. Woodman9, Rodabe N. Amaria9, Michael A. Davies9, Jeffrey E. Gershenwald1, Patrick Hwu9, Juneyoung Lee1, J. Zhang1, Lisa M. Coussens4, Zachary A. Cooper1, P. Andrew Futreal1, Carrie R. Daniel1,2, Nadim J. Ajami3, Joseph F. Petrosino3, Michael T. Tetzlaff1, Pradeep Sharma1, James P. Allison3, Robert R. Jenq1, Jennifer A. Wargo1
1University of Texas
2UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER
3Department of Molecular Virology and Microbiology
4University of Oregon
5Department of Breast Medical Oncology
6MetaGenoPolis
7Immunologie des tumeurs et immunothérapie
8Institut Gustave Roussy
9Department of Melanoma Medical Oncology

Tóm tắt

Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade. They profiled samples from patients with lung and kidney cancers and found that nonresponding patients had low levels of the bacterium Akkermansia muciniphila . Oral supplementation of the bacteria to antibiotic-treated mice restored the response to immunotherapy. Matson et al. and Gopalakrishnan et al. studied melanoma patients receiving PD-1 blockade and found a greater abundance of “good” bacteria in the guts of responding patients. Nonresponders had an imbalance in gut flora composition, which correlated with impaired immune cell activity. Thus, maintaining healthy gut flora could help patients combat cancer. Science , this issue p. 91 , p. 104 , p. 97 ; see also p. 32

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American Association for the Advancement of Science (AAAS)

Tập 359 Số 6371

97-103

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