Synaptic Connections in Vitro: Modulation of Number and Efficacy by Electrical Activity

American Association for the Advancement of Science (AAAS) - Tập 244 Số 4904 - Trang 585-587 - 1989
Phillip G. Nelson1, Chang Yu1, R. Douglas Fields1, Elaine A. Neale1
1Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, Bethesda, MD 20892.

Tóm tắt

The functional architecture of synaptic circuits is determined to a crucial degree by the patterns of electrical activity that occur during development. Studies with an in vitro preparation of mammalian sensory neurons projecting to ventral spinal cord neurons show that electrical activity induces competitive processes that regulate synaptic efficacy so as to favor activated pathways over inactive convergent pathways. At the same time, electrical activity initiates noncompetitive processes that increase the number of axonal connections between these sensory and spinal cord neurons.

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American Association for the Advancement of Science (AAAS)

Tập 244 Số 4904

585-587

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