Assessment of cognition in early dementia

Wiley - Tập 7 Số 3 - 2011
Nina B. Nina B.1, Laurie M. Laurie M.1, Maria C. Maria C.2, Reisa Reisa3,4, Ronald C. Ronald C.5, Holly B. Holly B.6, Peter J. Peter J.7,8, Robin Robin9,10, Michela Michela11, Jacob Jacob12, Albert Albert13, Katherine Katherine14, Jonathan Jonathan15, Jeffrey Jeffrey16, Brian R. Brian R.17, Marilyn S. Marilyn S.18, Molly V. Molly V.1, John A. John A.19,20, C. Munro C. Munro21, Sarah T. Sarah T.22, David David23, Stephen Stephen24, Andrew E. Andrew E.25,26, Jason Jason27, Jennifer J. Jennifer J.28, Lisa Lisa29,30,31,32, Adriana Adriana33, Tamar H. Tamar H.34, Mary Mary35,36, Debra Debra37, Irene Irene38, Joel H. Joel H.14, Tanis J. Tanis J.39
1Division of Neuroscience, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
2Alzheimer's Association Chicago IL USA
3Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
4Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
5Department of Neurology, Mayo Clinic, Rochester, MN, USA
6Pfizer, New York, NY, USA
7Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA
8Department of Neurology Alpert Medical School of Brown University Providence RI USA
9Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
10Psychology Service, South Texas Veterans Health Care System San Antonio TX USA
11Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA
12Division of Neuroscience, Department of Behavioral Neuroscience and Neurology ONPRC, Oregon Health and Science University Portland OR USA
13Institute for Creative Technologies, University of Southern California Playa Vista CA USA
14Department of Neurology, University of California, San Francisco, CA, USA
15Division of Behavioral and Social Research National Institute on Aging, National Institutes of Health Bethesda MD USA
16Departments of Neurology and Biomedical Engineering Layton Aging and Alzheimer's Disease Center, Oregon Center for Aging and Technology, Oregon Health and Science University and Portland Veteran's Affairs Medical Center Portland OR USA
17Department of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI, USA
18Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
19James A. Haley VA Medical Center, Tampa, FL USA
20Department of Psychiatry University of South Florida Tampa FL USA
21University of Texas Southwestern Medical Center; Dallas, TX, USA
22Department of Neurology, University of California, Davis, Sacramento, CA, USA
23Department of Psychology Washington University St. Louis MO USA
24Schey Center for Cognitive Neuroimaging, Neurological Institute, Cleveland Clinic Cleveland OH USA
25Department of Neurology Boston University Alzheimer's Disease Center, Boston University School of Medicine Bedford MA USA
26Center for Translational Cognitive Neuroscience, Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital Bedford MA USA
27Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
28Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center New York NY USA
29Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago IL, USA
30Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA
31Department of Behavioral Sciences Rush University Medical Center Chicago IL USA
32Rush Institute for Healthy Aging, Rush University Medical Center Chicago IL USA
33Baylor College of Medicine, Houston, TX, USA
34Department of Psychiatry, University of California, San Diego, CA, USA
35Departments of Psychiatry and Neurology School of Medicine, University of Pittsburgh Pittsburgh PA USA
36Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
37National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
38Division of Movement Disorders, Department of Neurology University of Louisville Louisville KY USA
39Department of Psychiatry and Psychology Mayo Clinic, College of Medicine Jacksonville FL USA

Tóm tắt

Better tools for assessing cognitive impairment in the early stages of Alzheimer's disease (AD) are required to enable diagnosis of the disease before substantial neurodegeneration has taken place and to allow for detection of subtle changes in the early stages of progression of the disease. The National Institute on Aging and the Alzheimer's Association convened a meeting to discuss state‐of‐the art methods for cognitive assessment, including computerized batteries, as well as new approaches in the pipeline. Speakers described research using novel tests of object recognition, spatial navigation, attentional control, semantic memory, semantic interference, prospective memory, false memory, and executive function as among the tools that could provide earlier identification of individuals with AD. In addition to early detection, there is a need for assessments that reflect real‐world situations so as to better assess functional disability. It is especially important to develop assessment tools that are useful in ethnically, culturally, and linguistically diverse populations as well as in individuals with neurodegenerative disease other than AD.

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