Impact of migraine on fibromyalgia symptoms
Tóm tắt
Fibromyalgia (FMS) and high frequency episodic/chronic migraine (M) very frequently co-occur, suggesting common pathophysiological mechanisms; both conditions display generalized somatic hyperalgesia. In FMS-M comorbidity we assessed if: a different level of hyperalgesia is present compared to one condition only; hyperalgesia is a function of migraine frequency; migraine attacks trigger FMS symptoms. Female patients with fibromyalgia (FMS)(n.40), high frequency episodic migraine (M1)(n.41), chronic migraine (M2)(n.40), FMS + M1 (n.42) and FMS + M2 (n.40) underwent recording of: −electrical pain thresholds in skin, subcutis and muscle and pressure pain thresholds in control sites, −pressure pain thresholds in tender points (TePs), −number of monthly migraine attacks and fibromyalgia flares (3-month diary). Migraine and FMS parameters were evaluated before and after migraine prophylaxis, or no prophylaxis, for 3 months with calcium-channel blockers, in two further FMS + H1 groups (n.49, n.39). 1-way ANOVA was applied to test trends among groups, Student’s t-test for paired samples was used to compare pre and post-treatment values. The lowest electrical and pressure thresholds at all sites and tissues were found in FMS + M2, followed by FMS + H1, FMS, M2 and M1 (trend: p < 0.0001). FMS monthly flares were progressively higher in FMS, FMS + M1 and FMS + M2 (p < 0.0001); most flares (86–87 %) occurred within 12 h from a migraine attack in co-morbid patients (p < 0.0001). Effective migraine prophylaxis vs no prophylaxis also produced a significant improvement of FMS symptoms (decreased monthly flares, increased pain thresholds)(0.0001 < p < 0.003). Co-morbidity between fibromyalgia and migraine involves heightened somatic hyperalgesia compared to one condition only. Increased migraine frequency – with shift towards chronicity – enhances both hyperalgesia and spontaneous FMS pain, which is reversed by effective migraine prophylaxis. These results suggest different levels of central sensitization in patients with migraine, fibromyalgia or both conditions and a role for migraine as a triggering factor for FMS.
Tài liệu tham khảo
citation_journal_title=J Am Osteopath Assoc; citation_title=Fibromyalgia: a clinical update; citation_author=RA Hawkins; citation_volume=113; citation_publication_date=2013; citation_pages=680-9; citation_doi=10.7556/jaoa.2013.034; citation_id=CR1
citation_journal_title=Curr Pain Headache Rep; citation_title=Worldwide epidemiology of fibromyalgia; citation_author=LP Queiroz; citation_volume=17; citation_publication_date=2013; citation_pages=356; citation_doi=10.1007/s11916-013-0356-5; citation_id=CR2
citation_journal_title=Arthritis Rheum; citation_title=The American College of Rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee; citation_author=F Wolfe, HA Smythe, MB Yunus, RM Bennett, C Bombardier, DL Goldenberg, P Tugwell, SM Campbell, M Abeles, P Clark; citation_volume=33; citation_publication_date=1990; citation_pages=160-72; citation_doi=10.1002/art.1780330203; citation_id=CR3
citation_journal_title=Arthritis Care Res (Hoboken); citation_title=The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity; citation_author=F Wolfe, DJ Clauw, MA Fitzcharles, DL Goldenberg, RS Katz, P Mease, AS Russell, IJ Russell, JB Winfield, MB Yunus; citation_volume=62; citation_publication_date=2010; citation_pages=600-10; citation_doi=10.1002/acr.20140; citation_id=CR4
citation_journal_title=Curr Pain Headache Rep; citation_title=Fibromyalgia comorbid with anxiety disorders and depression: combined medical and psychological treatment; citation_author=M Bernik, TP Sampaio, L Gandarela; citation_volume=17; citation_publication_date=2013; citation_pages=358; citation_doi=10.1007/s11916-013-0358-3; citation_id=CR5
citation_journal_title=Am J Gastroenterol; citation_title=Sensitivity disturbances in patients with irritable bowel syndrome and fibromyalgia; citation_author=MP Caldarella, MA Giamberardino, F Sacco, G Affaitati, A Milano, R Lerza, C Balatsinou, F Laterza, SD Pierdomenico, F Cuccurullo, M Neri; citation_volume=101; citation_publication_date=2006; citation_pages=2782-9; citation_doi=10.1111/j.1572-0241.2006.00823.x; citation_id=CR6
citation_journal_title=Handb Clin Neurol; citation_title=Chapter 24. Referred pain from internal organs; citation_author=MA Giamberardino, G Affaitati, R Costantini; citation_volume=81; citation_publication_date=2006; citation_pages=343-61; citation_doi=10.1016/S0072-9752(06)80028-X; citation_id=CR7
citation_journal_title=J Musculoske Pain; citation_title=Visceral referred pain; citation_author=MA Giamberardino, G Affaitati, R Costantini; citation_volume=18; citation_publication_date=2010; citation_pages=403-10; citation_doi=10.3109/10582452.2010.502624; citation_id=CR8
citation_journal_title=Arch Intern Med; citation_title=Chronic widespread pain and its comorbidities: a population-based study; citation_author=K Kato, PF Sullivan, B Evengård, NL Pedersen; citation_volume=166; citation_publication_date=2006; citation_pages=1649-54; citation_doi=10.1001/archinte.166.15.1649; citation_id=CR9
citation_journal_title=Expert Rev Neurother; citation_title=Prevalence, clinical features and potential therapies for fibromyalgia in primary headaches; citation_author=M Tommaso; citation_volume=12; citation_publication_date=2012; citation_pages=287-95; citation_doi=10.1586/ern.11.190; citation_id=CR10
citation_journal_title=Curr Pain Headache Rep; citation_title=Tension-type headache and systemic medical disorders; citation_author=S Sacco, S Ricci, A Carolei; citation_volume=15; citation_publication_date=2011; citation_pages=438-43; citation_doi=10.1007/s11916-011-0222-2; citation_id=CR11
citation_journal_title=Compr Psychiatry; citation_title=Personality profiles and coping styles in migraine patients with fibromyalgia comorbidity; citation_author=M Tommaso, A Federici, A Loiacono, M Delussi, O Todarello; citation_volume=55; citation_publication_date=2014; citation_pages=80-6; citation_doi=10.1016/j.comppsych.2013.08.006; citation_id=CR12
citation_journal_title=Headache; citation_title=Frequency of migraine headaches in patients with fibromyalgia; citation_author=B Vij, MO Whipple, SJ Tepper, AB Mohabbat, M Stillman, A Vincent; citation_volume=55; citation_publication_date=2015; citation_pages=860-5; citation_doi=10.1111/head.12590; citation_id=CR13
citation_journal_title=Clin Rheumatol; citation_title=The prevalence of fibromyalgia and its relation with headache characteristics in episodic migraine; citation_author=S Küçükşen, E Genç, H Yılmaz, A Sallı, İA Gezer, AY Karahan, E Salbaş, HT Cingöz, Ö Nas, H Uğurlu; citation_volume=32; citation_publication_date=2013; citation_pages=983-90; citation_doi=10.1007/s10067-013-2218-2; citation_id=CR14
citation_journal_title=Clin Rheumatol; citation_title=Fibromyalgia comorbidity in a community sample of adults with migraine; citation_author=DA Marcus, A Bhowmick; citation_volume=32; citation_publication_date=2013; citation_pages=1553-6; citation_doi=10.1007/s10067-013-2310-7; citation_id=CR15
citation_journal_title=Ann Int Med; citation_title=Narrative review: the pathophysiology of fibromyalgia; citation_author=AM Abeles, MH Pillinger, BM Solitar, M Abeles; citation_volume=146; citation_publication_date=2007; citation_pages=726-34; citation_doi=10.7326/0003-4819-146-10-200705150-00006; citation_id=CR16
citation_journal_title=Best Pract Res Clin Rheumatol; citation_title=Update on the genetics of the fibromyalgia syndrome; citation_author=JN Ablin, D Buskila; citation_volume=29; citation_publication_date=2015; citation_pages=20-8; citation_doi=10.1016/j.berh.2015.04.018; citation_id=CR17
citation_journal_title=Mayo Clin Proc; citation_title=Fibromyalgia and related conditions; citation_author=DJ Clauw; citation_volume=90; citation_publication_date=2015; citation_pages=680-92; citation_doi=10.1016/j.mayocp.2015.03.014; citation_id=CR18
citation_journal_title=Eur J Pain; citation_title=Effects of treatment of peripheral pain generators in fibromyalgia patients; citation_author=G Affaitati, R Costantini, A Fabrizio, D Lapenna, E Tafuri, MA Giamberardino; citation_volume=15; citation_publication_date=2011; citation_pages=61-9; citation_doi=10.1016/j.ejpain.2010.09.002; citation_id=CR19
citation_title=Comparative sensory evaluation of parietal tissues in painful and nonpainful areas in fibromyalgia and myofascial pain syndrome; citation_inbook_title=Proceedings of the 7th world congress on pain, progress in pain research and management; citation_publication_date=1994; citation_id=CR20; citation_author=L Vecchiet; citation_author=MA Giamberardino; citation_author=P Bigontina; citation_author=L Dragani; citation_publisher=IASP Press
citation_journal_title=Headache; citation_title=Pain perception studies in tension-type headache; citation_author=D Bezov, S Ashina, R Jensen, L Bendtsen; citation_volume=51; citation_publication_date=2011; citation_pages=262-71; citation_doi=10.1111/j.1526-4610.2010.01768.x; citation_id=CR21
citation_journal_title=J Headache Pain; citation_title=Habituation and sensitization in primary headaches; citation_author=G Coppola, C Lorenzo, J Schoenen, F Pierelli; citation_volume=14; citation_publication_date=2013; citation_pages=65; citation_doi=10.1186/1129-2377-14-65; citation_id=CR22
citation_journal_title=CNS Neurol Disord Drug Targets; citation_title=Central sensitisation phenomena in primary headaches: overview of a preventive therapeutic approach; citation_author=M Tommaso, M Sardaro, E Vecchio, C Serpino, M Stasi, M Ranieri; citation_volume=7; citation_publication_date=2008; citation_pages=524-35; citation_doi=10.2174/187152708787122932; citation_id=CR23
citation_journal_title=J Headache Pain; citation_title=Evidence of persistent central sensitization in chronic headaches: a multi-method study; citation_author=E Filatova, N Latysheva, A Kurenkov; citation_volume=9; citation_publication_date=2008; citation_pages=295-300; citation_doi=10.1007/s10194-008-0061-7; citation_id=CR24
citation_journal_title=J Headache Pain; citation_title=Chronic headache and fibromyalgia; citation_author=MA Giamberardino, E Tafuri, S Fabio, C Tana, A Costa, A Fabrizio, G Affaitati; citation_volume=12; citation_publication_date=2011; citation_pages=13; citation_doi=10.1007/s10194-011-0297-5; citation_id=CR25
citation_journal_title=J Headache Pain; citation_title=Sensory evaluation in fibromyalgia and headache; citation_author=A Savini, E Tafuri, G Affaitati, A Fabrizio, R Lerza, G Sidonio, MA Giamberardino; citation_volume=9; citation_publication_date=2008; citation_pages=25; citation_id=CR26
citation_journal_title=Pain; citation_title=Increased muscle pain sensitivity in patients with tension-type headache; citation_author=PT Schmidt-Hansen, P Svensson, L Bendtsen, T Graven-Nielsen, FW Bach; citation_volume=129; citation_publication_date=2007; citation_pages=113-21; citation_doi=10.1016/j.pain.2006.09.037; citation_id=CR27
citation_journal_title=Pain; citation_title=Quantitative sensory testing in children with migraine: preliminary evidence for enhanced sensitivity to painful stimuli especially in girls; citation_author=K Zohsel, J Hohmeister, R Oelkers-Ax, H Flor, C Hermann; citation_volume=123; citation_publication_date=2006; citation_pages=10-8; citation_doi=10.1016/j.pain.2005.12.015; citation_id=CR28
citation_journal_title=Neurotherapeutics; citation_title=Diabetic painful and insensate neuropathy: pathogenesis and potential treatments; citation_author=IG Obrosova; citation_volume=6; citation_publication_date=2009; citation_pages=638-47; citation_doi=10.1016/j.nurt.2009.07.004; citation_id=CR29
citation_journal_title=Pain Pract; citation_title=New and low-cost auto-algometry for screening hypertension-associated hypoalgesia; citation_author=A Viggiano, N Zagaria, MB Passavanti, MC Pace, A Paladini, C Aurilio, MA Tedesco, F Natale, R Calabrò, M Monda, E Luca; citation_volume=9; citation_publication_date=2009; citation_pages=260-5; citation_doi=10.1111/j.1533-2500.2009.00287.x; citation_id=CR30
citation_journal_title=Cephalalgia; citation_title=The international classification of headache disorders, 2nd edition; citation_author=; citation_volume=24; citation_publication_date=2004; citation_pages=1-150; citation_id=CR31
citation_journal_title=Cephalalgia; citation_title=The international classification of headache disorders, 3rd edition (beta version); citation_author=; citation_volume=33; citation_publication_date=2013; citation_pages=627-808; citation_doi=10.1177/0333102413487610; citation_id=CR32
citation_journal_title=Expert Opin Emerg Drugs; citation_title=Emerging drugs for migraine treatment; citation_author=MA Giamberardino, P Martelletti; citation_volume=20; citation_publication_date=2015; citation_pages=137-47; citation_doi=10.1517/14728214.2015.999040; citation_id=CR33
citation_journal_title=Expert Opin Drug Metab Toxicol; citation_title=The therapeutic armamentarium in migraine is quite elderly; citation_author=P Martelletti; citation_volume=11; citation_publication_date=2015; citation_pages=175-7; citation_doi=10.1517/17425255.2015.982089; citation_id=CR34
citation_journal_title=Pharmacol Rep; citation_title=Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain; citation_author=G Jagla, J Mika, W Makuch, I Obara, J Wordliczek, B Przewlocka; citation_volume=66; citation_publication_date=2014; citation_pages=459-65; citation_doi=10.1016/j.pharep.2013.11.004; citation_id=CR35
citation_journal_title=Headache; citation_title=Preventive migraine treatment. Continuum (Minneap Minn); citation_author=SD Silberstein; citation_volume=21; citation_publication_date=2015; citation_pages=973-89; citation_id=CR36
citation_journal_title=Pract Neurol; citation_title=Headache management: pharmacological approaches; citation_author=AJ Sinclair, A Sturrock, B Davies, M Matharu; citation_volume=15; citation_publication_date=2015; citation_pages=411-23; citation_id=CR37
citation_journal_title=J Musculoskelet Pain; citation_title=Muscle pain syndromes and fibromyalgia. Pressure algometry for quantification of diagnosis and treatment outcome; citation_author=AA Fischer; citation_volume=6; citation_publication_date=1998; citation_pages=152-7; citation_id=CR38
citation_journal_title=Pain; citation_title=Relationship between pain symptoms and referred sensory and trophic changes in patients with gallbladder pathology; citation_author=MA Giamberardino, G Affaitati, R Lerza, D Lapenna, R Costantini, L Vecchiet; citation_volume=114; citation_publication_date=2005; citation_pages=239-49; citation_doi=10.1016/j.pain.2004.12.024; citation_id=CR39
citation_journal_title=Pain; citation_title=Viscero-visceral hyperalgesia: characterization in different clinical models; citation_author=MA Giamberardino, R Costantini, G Affaitati, A Fabrizio, D Lapenna, E Tafuri, A Mezzetti; citation_volume=151; citation_publication_date=2010; citation_pages=307-22; citation_doi=10.1016/j.pain.2010.06.023; citation_id=CR40
citation_journal_title=Curr Opin Obstet Gynecol; citation_title=Pain thresholds in women with chronic pelvic pain; citation_author=MA Giamberardino, C Tana, R Costantini; citation_volume=26; citation_publication_date=2014; citation_pages=253-9; citation_doi=10.1097/GCO.0000000000000083; citation_id=CR41
Ángel García D, Martínez Nicolás I, Saturno Hernández PJ. Clinical approach to fibromyalgia: synthesis of evidence-based recommendations, a systematic review. Reumatol Clin. 2015; [Epub ahead of print]
citation_journal_title=Cephalalgia; citation_title=Fibromyalgia comorbidity in primary headaches; citation_author=M Tommaso, M Sardaro, C Serpino, F Costantini, E Vecchio, MP Prudenzano, P Lamberti, P Livrea; citation_volume=29; citation_publication_date=2009; citation_pages=453-64; citation_doi=10.1111/j.1468-2982.2008.01754.x; citation_id=CR43
citation_journal_title=Pain Med; citation_title=Are peripheral pain generators important in fibromyalgia and chronic widespread pain?; citation_author=R Gerwin; citation_volume=14; citation_publication_date=2013; citation_pages=777-8; citation_doi=10.1111/pme.12169; citation_id=CR44
citation_journal_title=Curr Pain Headache Rep; citation_title=Effects of treatment of myofascial trigger points on the pain of fibromyalgia; citation_author=MA Giamberardino, G Affaitati, A Fabrizio, R Costantini; citation_volume=15; citation_publication_date=2011; citation_pages=393-9; citation_doi=10.1007/s11916-011-0205-3; citation_id=CR45
citation_journal_title=Best Pract Res Clin Rheumatol; citation_title=Myofascial pain syndromes and their evaluation; citation_author=MA Giamberardino, G Affaitati, A Fabrizio, R Costantini; citation_volume=25; citation_publication_date=2011; citation_pages=185-98; citation_doi=10.1016/j.berh.2011.01.002; citation_id=CR46