White-matter hyperintensities in first-episode psychosis

British Journal of Psychiatry - Tập 193 Số 1 - Trang 25-30 - 2008
Marcus V. Zanetti1, Maristela S. Schaufelberger1, Cláudio Campi de Castro2, Paulo Rossi Menezes3, Jukka T. Salonen4, Philip McGuire5, Robin Murray5, Geraldo F. Busatto6
1Laboratory of Psychiatric Neuroimaging, Institute and Department of Psychiatry, University of São Paulo
2Department of Radiology, University of São Paulo
3Department of Preventive Medicine, Faculty of Medicine, and Section of Epidemiology, University Hospital, University of São Paulo
4Laboratory of Psychopathology and Psychiatric Therapeutics, Institute and Department of Psychiatry, University of São Paulo, São Paulo, Brazil
5Department of Psychological Medicine, Institute of Psychiatry, London, UK
6Laboratory of Psychiatric Neuroimaging, Institute and Department of Psychiatry, University of São Paulo, São Paulo, Brazil

Tóm tắt

BackgroundWhite-matter hyperintensities have been associated with both schizophrenia and mood disorders, particularly bipolar disorder, but results are inconsistent across studiesAimsTo examine whether white-matter hyperintensities are a vulnerability marker for psychosis or are specifically associated with bipolar disorderMethodT2-weighted magnetic resonance imaging data were acquired in 129 individuals with first-episode psychosis (either affective or non-affective psychoses) and 102 controls who were randomly selected from the same geographical areas. Visual white-matter hyperintensity ratings were used for group and subgroup comparisonsResultsThere were no statistically significant between-group differences in white-matter hyperintensity frequency or severity scores. No significant correlations were found between white-matter hyperintensity scores and duration of illness, duration of untreated psychosis, or severity of psychotic, manic or depressive symptomsConclusionsWhite-matter hyperintensities are not associated with vulnerability to psychosis in general, or specifically with affective psychoses. Further, first-episode psychosis investigations using more quantitative methods are warranted to confirm these findings

Từ khóa


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Thông tin xuất bản

British Journal of Psychiatry

Tập 193 Số 1

25-30

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