Can pulsatile CSF flow across the cerebral aqueduct cause ventriculomegaly? A prospective study of patients with communicating hydrocephalus
Tóm tắt
Communicating hydrocephalus is a disease where the cerebral ventricles are enlarged. It is characterized by the absence of detectable cerebrospinal fluid (CSF) outflow obstructions and often with increased CSF pulsatility measured in the cerebral aqueduct (CA). We hypothesize that the cardiac-related pulsatile flow over the CA, with fast systolic outflow and slow diastolic inflow, can generate net pressure effects that could source the ventriculomegaly in these patients. This would require a non-zero cardiac cycle averaged net pressure difference (Δ
We tested the hypothesis by calculating Δ
The Δ
The results supported the hypothesis with respect to the direction of Δ
Từ khóa
Tài liệu tham khảo
Rekate HL. A contemporary definition and classification of hydrocephalus. Semin Pediatr Neurol. 2009;16:9–15.
Mascalchi M, Ciraolo L, Tanfani G, Taverni N, Inzitari D, Siracusa GF, et al. Cardiac-gated phase MR imaging of aqueductal CSF flow. J Comput Assist Tomogr. 1988;12:923–6.
Abbey P, Singh P, Khandelwal N, Mukherjee KK. Shunt surgery effects on cerebrospinal fluid flow across the aqueduct of Sylvius in patients with communicating hydrocephalus. J Clin Neurosci. 2009;16:514–8.
Balédent O, Gondry-Jouet C, Meyer M-E, De Marco G, Le Gars D, Henry-Feugeas M-C, et al. Relationship between cerebrospinal fluid and blood dynamics in healthy volunteers and patients with communicating hydrocephalus. Invest Radiol. 2004;39:45–55.
Greitz D, Hannerz J, Rahn T, Bolander H, Ericsson A. MR imaging of cerebrospinal fluid dynamics in health and disease. On the vascular pathogenesis of communicating hydrocephalus and benign intracranial hypertension. Acta Radiol. 1994;35:204–11.
Di Rocco C, Pettorossi VE, Caldarelli M, Mancinelli R, Velardi F. Communicating hydrocephalus induced by mechanically increased amplitude of the intraventricular cerebrospinal fluid pressure: experimental studies. Exp Neurol. 1978;59:40–52.
Di Rocco C, Di Trapani G, Pettorossi VE, Caldarelli M. On the pathology of experimental hydrocephalus induced by artificial increase in endoventricular CSF pulse pressure. Childs Brain. 1979;5:81–95.
Pettorossi VE, Di Rocco C, Mancinelli R, Caldarelli M, Velardi F. Communicating hydrocephalus induced by mechanically increased amplitude of the intraventricular cerebrospinal fluid pulse pressure: rationale and method. Exp Neurol. 1978;59:30–9.
Sweetman B, Xenos M, Zitella L, Linninger AA. Three-dimensional computational prediction of cerebrospinal fluid flow in the human brain. Comput Biol Med. 2011;41:67–75.
Bardan G, Plouraboue F, Zagzoule M, Baledent O. Simple patient-based transmantle pressure and shear estimate from cine phase-contrast MRI in cerebral aqueduct. IEEE Trans Biomed Eng. 2012;59:2874–83.
Qvarlander S, Ambarki K, Wåhlin A, Jacobsson J, Birgander R, Malm J, et al. Cerebrospinal fluid and blood flow patterns in idiopathic normal pressure hydrocephalus. Acta Neurol Scand. 2017;135:576–84.
Oliveira PJ, Pinho FT, Schulte A. A general correlation for the local loss coefficient in Newtonian axisymmetric sudden expansions. Int J Heat Fluid Flow. 1998;19:655–60.
Bullen PR, Cheeseman DJ, Hussain LA, Ruffellt AE. The determination of pipe contraction pressure loss coefficients for incompressible turbulent flow. Int J Heat Fluid Flow. 1987;8:111–8.
Stephensen H, Tisell M, Wikkelsö C, Hodge CJ, Gjerris F, Børgesen SE, et al. There is no transmantle pressure gradient in communicating or noncommunicating hydrocephalus. Neurosurgery. 2002;50:763–71 (discussion 771-3).
Eide PK, Sæhle T. Is ventriculomegaly in idiopathic normal pressure hydrocephalus associated with a transmantle gradient in pulsatile intracranial pressure? Acta Neurochir. 2010;152:989–95.
Dutta-Roy T, Wittek A, Miller K. Biomechanical modelling of normal pressure hydrocephalus. J Biomech. 2008;41:2263–71.
Kurtcuoglu V, Soellinger M, Summers P, Boomsma K, Poulikakos D, Boesiger P, et al. Computational investigation of subject-specific cerebrospinal fluid flow in the third ventricle and aqueduct of Sylvius. J Biomech. 2007;40:1235–45.
Linninger AA, Xenos M, Zhu DC, Somayaji MR, Kondapalli S, Penn RD. Cerebrospinal fluid flow in the normal and hydrocephalic human brain. IEEE Trans Biomed Eng. 2007;54:291–302.
Relkin N, Marmarou A, Klinge P, Bergsneider M, Black PM. Diagnosing idiopathic normal-pressure hydrocephalus. Neurosurgery. 2005;57:S4–16 (discussion ii–v).
Noble DJ, Scoffings D, Ajithkumar T, Williams MV, Jefferies SJ. Fast imaging employing steady-state acquisition (FIESTA) MRI to investigate cerebrospinal fluid (CSF) within dural reflections of posterior fossa cranial nerves. Br J Radiol. 2016;89:20160392.
Hingwala D, Chatterjee S, Kesavadas C, Thomas B, Kapilamoorthy TR. Applications of 3D CISS sequence for problem solving in neuroimaging. Indian J Radiol Imaging. 2011;21:90–7.
Wahlin A, Ambarki K, Hauksson J, Birgander R, Malm J, Eklund A. Phase contrast MRI quantification of pulsatile volumes of brain arteries, veins, and cerebrospinal fluids compartments: repeatability and physiological interactions. J Magn Reson Imaging. 2012;35:1055–62.
Heiberg E, Sjögren J, Ugander M, Carlsson M, Engblom H, Arheden H. Design and validation of Segment—freely available software for cardiovascular image analysis. BMC Med Imaging. 2010;10:1.
Bloomfield IG, Johnston IH, Bilston LE. Effects of proteins, blood cells and glucose on the viscosity of cerebrospinal fluid. Pediatr Neurosurg. 1998;28:246–51.
Behrens A, Lenfeldt N, Qvarlander S, Koskinen LO, Malm J, Eklund A. Are intracranial pressure wave amplitudes measurable through lumbar puncture? Acta Neurol Scand. 2013;127:233–41.
Ringstad G, Emblem KE, Geier O, Alperin N, Eide PK. Aqueductal stroke volume: comparisons with intracranial pressure scores in idiopathic normal pressure hydrocephalus. Am J Neuroradiol. 2015;36:1623–30.
Chiang WW, Takoudis CG, Lee SH, Weis-McNulty A, Glick R, Alperin N. Relationship between ventricular morphology and aqueductal cerebrospinal fluid flow in healthy and communicating hydrocephalus. Invest Radiol. 2009;44:192–9.
Fin L, Grebe R. Three dimensional modeling of the cerebrospinal fluid dynamics and brain interactions in the aqueduct of sylvius. Comput Methods Biomech Biomed Eng. 2003;6:163–70.
Spijkerman JM, Geurts LJ, Siero JCW, Hendrikse J, Luijten PR, Zwanenburg JJM. Phase contrast MRI measurements of net cerebrospinal fluid flow through the cerebral aqueduct are confounded by respiration. J Magn Reson Imaging. 2019;49:433–44.
Ragunathan S, Pipe JG. Radiofrequency saturation induced bias in aqueductal cerebrospinal fluid flow quantification obtained using two-dimensional cine phase contrast magnetic resonance imaging. Magn Reson Med. 2018;79:2067–76.