Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States

Alzheimer's & Dementia - Tập 7 Số 1 - Trang 80-93 - 2011
Walter A. Rocca1,2, Ronald C. Petersen1,2,3, David S. Knopman1,3, Liesi E. Hebert4, Denis A. Evans5,4, Kathleen Hall6, Sujuan Gao7, Frederick W. Unverzagt6, Kenneth M. Langa8,9,10, Eric B. Larson11, Lon R. White12,13,14
1Department of Neurology, College of Medicine, Mayo Clinic, Rochester, MN, USA
2Division of Epidemiology, Department of Health Sciences Research, College of Medicine, Mayo Clinic, Rochester, MN, USA
3Mayo Alzheimer's Disease Research Center, Mayo Clinic, Rochester, MN, USA
4Rush Institute for Healthy Aging, Rush University Medical Center Chicago IL USA
5Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA
6Department of Psychiatry, School of Medicine, Indiana University, Indianapolis, IN, USA
7Department of Biostatistics, School of Medicine, Indiana University, Indianapolis, IN, USA
8Division of General Medicine, Department of Medicine, School of Medicine, University of Michigan, Ann Arbor, MI, USA
9Institute for Social Research, University of Michigan Ann Arbor, MI USA
10Veterans Affairs Center for Practice Management and Outcomes Research, Ann Arbor, MI, USA
11Group Health Research Institute, Seattle, WA, USA
12Department of Biology, Chaminade University, Honolulu, HI, USA
13Department of Pathology, School of Medicine, University of Washington, Seattle, WA, USA
14Kuakini Medical Center, Honolulu, HI, USA

Tóm tắt

Declines in heart disease and stroke mortality rates are conventionally attributed to reductions in cigarette smoking, recognition and treatment of hypertension and diabetes, effective medications to improve serum lipid levels and to reduce clot formation, and general lifestyle improvements. Recent evidence implicates these and other cerebrovascular factors in the development of a substantial proportion of dementia cases. Analyses were undertaken to determine whether corresponding declines in age‐specific prevalence and incidence rates for dementia and cognitive impairment have occurred in recent years. Data spanning 1 or 2 decades were examined from community‐based epidemiological studies in Minnesota, Illinois, and Indiana, and from the Health and Retirement Study, which is a national survey. Although some decline was observed in the Minnesota cohort, no statistically significant trends were apparent in the community studies. A significant reduction in cognitive impairment measured by neuropsychological testing was identified in the national survey. Cautious optimism appears justified.

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Alzheimer's & Dementia

Tập 7 Số 1

80-93

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