Ethosuximide in epileptic women during pregnancy and lactation period. Placental transfer, serum concentrations in nursed infants and clinical status.

British Journal of Clinical Pharmacology - Tập 18 Số 5 - Trang 671-677 - 1984
W Kuhnz1,2, S Koch1,2, S Jakob1,2, Anika M. Hartmann1,2, H Helge1,2, Heinz Nau1,2
1Freie Universitat Berlin, Heubnerweg 6, 1000 Berlin 19, F.R.
2lInstitut fiir Toxikologie und Embryonalpharmakologie, Freie Universitat Berlin, Garystrasse 9, 1000 Berlin 33 and 2Kinderklinik,

Tóm tắt

A total of 10 epileptic mothers treated with ethosuximide (ES) as well as their 13 newborns were included in this study. At birth foetal/maternal serum concentration ratios were 0.97 +/‐ 0.02 (n = 7) and ES half‐lives in three neonates were 32, 37 and 38 h. The breast milk concentrations of ES were similar to those in maternal serum (milk/serum: 0.86 +/‐ 0.08, n = 12) and the nursed infants maintained serum levels between 15 and 40 micrograms/ml. Two major malformations (bilateral clefting, hare‐lip) were observed in two neonates whose mothers received either ES/PB or ES/PMD comedication. The number of minor anomalies was higher in the ES group (6.2, n = 12) than in the pair‐matched control group of infants born to non‐epileptic mothers (2.1, n = 10). Neonatal behaviour complications occurred in seven infants, two of them were severely affected.

Từ khóa


Tài liệu tham khảo

Buchanan R. A., 1969, Absorption and elimination of ethosuximide in children., J. clin. Pharmac., 9, 393

10.1016/S0022-3476(70)80038-5

10.1111/j.1469-8749.1966.tb01796.x

10.1111/j.1528-1157.1979.tb04777.x

10.1016/S0140-6736(81)90354-8

10.1111/j.1365-2125.1979.tb04654.x

Kleining G., 1968, Soziale Selbstein‐stufung. Ein Instrument zur Messung sozialer Schichten., Kölner Zeitschrift für Soziologie und Sozialpsychologie, 20, 502

10.1055/s-2008-1069536

10.1111/j.1528-1157.1978.tb05033.x

Kuhnz W., 1984, Ther. Drug. Monit.

10.1007/BF00561476

Nau H., 1981, Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers., J. Pharmac. exp. Ther., 219, 768

10.2165/00003088-198207060-00003

10.1111/j.1365-2125.1981.tb01320.x

Rating D., 1982, Epilepsy, pregnancy and the child, 283

Sherwin A. L., 1972, Antiepileptic drugs, 443

10.1016/S0022-3476(69)80224-6

Thông tin
Thông tin xuất bản

British Journal of Clinical Pharmacology

Tập 18 Số 5

671-677

Thông tin tác giả