Role of diet and nutritional management in non‐alcoholic fatty liver disease

Journal of Gastroenterology and Hepatology (Australia) - Tập 28 Số S4 - Trang 81-87 - 2013
Jian‐Gao Fan1, Haixia Cao1
1Department of Gastroenterology; Xinhua Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Children's Digestion and Nutrition; Shanghai China

Tóm tắt

AbstractNon‐alcoholic fatty liver disease (NAFLD) encompasses a spectrum ranging from simple steatosis to non‐alcoholic steatohepatitis, which causes an increased risk of cirrhosis, type 2 diabetes, and cardiovascular complications. With the worldwide growing incidence of obesity, sedentary lifestyle, and unhealthy dietary pattern, NAFLD has currently been recognized as a major health burden. Dietary patterns and nutrients are the important contributors to the development, progression, and treatment of NAFLD and associated metabolic comorbidities. Generally, hypercaloric diet, especially rich in trans/saturated fat and cholesterol, and fructose‐sweetened beverages seem to increase visceral adiposity and stimulate hepatic lipid accumulation and progression into non‐alcoholic steatohepatitis, whereas reducing caloric intake, increasing soy protein and whey consumption, and supplement of monounsaturated fatty acids, omega‐3 fatty acids, and probiotics have preventive and therapeutic effects. In addition, choline, fiber, coffee, green tea, and light alcohol drinking might be protective factors for NAFLD. Based on available data, at least 3–5% of weight loss, achieved by hypocaloric diet alone or in conjunction with exercise and behavioral modification, generally reduces hepatic steatosis, and up to 10% weight loss may be needed to improve hepatic necroinflammation. A sustained adherence to diet rather than the actual diet type is a major predictor of successful weight loss. Moreover, a healthy diet has benefits beyond weight reduction on NAFLD patients whether obese or of normal weight. Therefore, nutrition serves as a major route of prevention and treatment of NAFLD, and patients with NAFLD should have an individualized diet recommendation.

Từ khóa


Tài liệu tham khảo

10.1053/j.gastro.2012.04.001

10.1111/j.1751-2980.2010.00476.x

10.1016/j.jhep.2008.10.010

10.1097/MCO.0b013e3283566614

10.1097/MCG.0b013e31824cf51e

10.1016/j.jada.2011.10.007

10.1016/j.jhep.2012.07.003

10.1503/cmaj.045037

10.1056/NEJMoa0804748

Moyer VA, 2012, Screening for and management of obesity in adults: U.S. Preventive Services Task Force recommendation statement, Ann. Intern. Med., 157, 373

10.1016/j.jhep.2011.06.010

10.3945/ajcn.111.022533

10.1002/hep.23535

10.1172/JCI37385

10.1016/j.jnutbio.2011.09.006

10.6061/clinics/2013(01)OA03

10.1002/hep.25789

10.1016/j.cmet.2012.04.004

10.1016/j.jhep.2011.08.018

10.1371/journal.pone.0037827

10.3945/ajcn.111.030114

10.3945/ajcn.2008.27296

10.1016/j.clnu.2011.01.006

10.1016/j.bbalip.2009.09.007

10.1097/MOG.0b013e32834e7b4b

10.1111/j.1753-4887.2011.00440.x

10.1111/j.1365-2036.2011.04916.x

10.1002/hep.24731

10.1007/s00125-011-2446-4

Rodríguez‐Hernández H, 2011, Decrease of aminotransferase levels in obese women is related to body weight reduction, irrespective of type of diet, Ann. Hepatol., 10, 486, 10.1016/S1665-2681(19)31517-0

10.1097/MPG.0b013e31822cdedf

10.3945/ajcn.112.038695

10.1097/MCO.0b013e3283544477

10.1097/MCO.0b013e3283547157

10.1136/adc.2010.192401

10.3748/wjg.v18.i18.2203

10.1111/j.1478-3231.2011.02730.x

10.1016/j.jhep.2012.03.024

10.1001/jama.2011.520

10.1001/jama.2011.1437

10.1016/j.jnutbio.2010.10.002

Aller R, 2011, Effect of a probiotic on liver aminotransferases in nonalcoholic fatty liver disease patients: a double blind randomized clinical trial, Eur. Rev. Med. Pharmacol. Sci., 15, 1090

10.1007/s10620-011-1887-4

Thông tin
Thông tin xuất bản

Journal of Gastroenterology and Hepatology (Australia)

Tập 28 Số S4

81-87

Thông tin tác giả