Trained immunity: A program of innate immune memory in health and disease

American Association for the Advancement of Science (AAAS) - Tập 352 Số 6284 - 2016
Mihai G. Netea1, Leo A. B. Joosten1, Eicke Latz2,3,4, Kingston H. G. Mills5, Gioacchino Natoli6, Hendrik G. Stunnenberg7, Luke O'neill5, Ramnik J. Xavier8,9
1Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands
2Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
3German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
4Institute of Innate Immunity, Bonn University, Bonn, Germany.
5School of Biochemistry and Immunology, Trinity College Dublin, Ireland
6Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
7Department of Molecular Biology, Faculties of Science and Medicine, Radboud Institute of Molecular Life Sciences, Radboud University, Nijmegen, Netherlands
8Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
9The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA

Tóm tắt

Training immune cells to remember Classical immunological memory, carried out by T and B lymphocytes, ensures that we feel the ill effects of many pathogens only once. Netea et al. review how cells of the innate immune system, which lack the antigen specificity, clonality, and longevity of T cell and B cells, have some capacity to remember, too. Termed “trained immunity,” the property allows macrophages, monocytes, and natural killer cells to show enhanced responsiveness when they reencounter pathogens. Epigenetic changes largely drive trained immunity, which is shorter lived and less specific than classical memory but probably still gives us a leg up during many infections. Science , this issue p. 10.1126/science.aaf1098

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American Association for the Advancement of Science (AAAS)

Tập 352 Số 6284

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