Valproic acid and ethosuximide interaction

Annals of Neurology - Tập 7 Số 6 - Trang 583-584 - 1980
Richard H. Mattson1, Joyce A. Cramer1
1Epilepsy Center, Veterans Administration Medical Center, West Haven, and the Department of Neurology, Yale University School of Medicine, New Haven, CT

Tóm tắt

AbstractThe addition of valproic acid to ethosuximide in treatment to prevent seizures caused increased serum concentration of ethosuximide in four of five patients observed. Ethosuximide levels increased from 73 to 112 m̈g/ml (53% higher), with concomitant toxicity. Both were reversed by reduction of the ethosuximide dose from 27.4 to 20.4 mg/kg. Serum concentrations of these two drugs should be monitored closely when they are given together.

Từ khóa


Tài liệu tham khảo

10.1212/WNL.29.6.904

Chang T, 1972, Antiepileptic Drugs, 425

10.1097/00007691-197901000-00011

Kapetanovic I, 1980, Antiepileptic Therapy: Advances in Drug Monitoring, 373

LoiseauP OrgogozoJM CenraudB et al:Further pharmacokinetic observations on the interaction between phenobarbital and valproic acid in epileptic patients in Wada JA Penry JK (eds): Epilepsy 1978: The 10th International Symposium. New York Raven 1979(in press)

Mattson RH, 1979, Current Neurology, 229

10.1002/ana.410030105

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Annals of Neurology

Tập 7 Số 6

583-584

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