Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)

Springer Science and Business Media LLC - Tập 11 - Trang 1358-1361 - 1994
Per Artursson1, Tuulikki Lindmark1, Stanley S. Davis2,3, Lisbeth Illum2,3
1Department of Pharmaceutics, Biomedical Centre, Uppsala University, Sweden
2Department of Pharmaceutical Sciences, Nottingham University, Nottingham, UK
3DanBioSyst UK Ltd., Albert Einstein Centre, Nottingham, UK

Tài liệu tham khảo

C-M. Lehr, J.A. Bouwstra, E.H. Schacht and H.E. Junginger. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J.Pharm. 78:43–48 (1992). L. Illum. Nasal delivery of peptides. Factors affecting nasal absorption. DJA Crommelin and K.K. Midha (Eds.) Topics in Pharmaceutical Sciences. Scientific Publishers Stuttgart, Stuttgart, pp 74–82 (1992) L. Illum, N.F. Farraj and S.S. Davis. Chitosan as a novel nasal delivery system for peptide drugs. Pharm. Res. (in press). M.N. Hart, L.F. VanDyk, S.A. Moore, D.M. Shasby and P.A. Cancilla. Differential opening of the brain endothelial barrier following neutralisation of the endothelial luminal anionic charge in vitro. J.Neuropathol. Exp. Neurol. 46: 141–153 (1987). G. Wilson. Growth and characterisation of cell and tissue cultures for the study of drug transport. G. Wilson, S.S. Davis, L. Illum and A. Zweibaum (Eds) Pharmaceutical applications of cell and tissue culture to drug transport. Plenum Press, New York, pp. 15–25 (1991). M. Pinto, S. Robine-Leon, M.D. Appay, M. Kedinger, N. Triadou, E. Dussaulx, B. Lacroix, P. Assmann-Simon, K. Haffen, J. Fogh and A. Zweibaum. Enterocyte — like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture. Biol. Cell 47: 323–330 (1983). E.K. Anderberg, C. Nystrom and P. Artursson. Epithelial transport of drugs in cell culture. VII. Effects of pharmaceutical surfactant excipients and bile acids on transepithelial permeability in monolayers of human intestinal epithelial (Caco-2) cells. J.Pharm. Sci. 81: 879–887 (1992). E. Bjork, U. Isaksson, P. Edman and P. Artursson. Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junction. J. Drug Targeting (in press). J. Fogh, J.M. Fogh and T.J. Orfeo. One hundred and twenty seven cultured human tumor cell lines producing tumors in nude mice. J. Natl. Cancer Inst. 59: 221–226, (1977). P. Artursson. Epithelial transport of drugs. I. A model for studying the transport of drugs (β-blocking agents) over an intestinal epithelial cell line (Caco-2). J.Pharm. Sci.. 79: 476–482 (1990). P. Artursson and J. Karlsson. Correlation between oral drug absorption in humans and apparent drug permeability coefficients in human intestinal epithelial (Caco-2) cells. Biochem. Biophys. Res. Commun. 175: 880–885 (1991). P.M. Reardon, C.H. Gochoco, K.L. Audus, G. Wilson and P.L. Smith. In vitro nasal transport across ovine mucosa: Effects of ammonium glycyrrhizinate on electrical properties and permeability of growth hormone releasing peptide, mannitol and lucifer yellow. Pharm. Res. 10: 553–561 (1993). E.K. Anderberg and P. Artursson. Epithelial transport of drugs in cell culture. VIII. The effects of the pharmaceutical surfactant excipient sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells. J. Pharm. Sci. 82: 392–398 (1993). L.J. Filar and M.G. Wirick. Bulk and solutions properties of chitosan. R.A.A. Muzzarelli and E.R. Parisier (Eds.) Proceedings of the first international conference on chitin/chitosan, Massachusetts, pp 169–181 (1977). A.B. Chan, C.N. Allen, N.L. Simmons, M.E. Parsons and B.H. Hirst. Resistance to acid of canine kidney (MDCK) and human colonic (T84) and ileo-caecal (HCT-8) adenocarcinoma epithelial cell monolayers in vitro. Quart. J. Exp. Physiol. 74: 553–556 (1989). I. Meza, M. Sabanero, E. Stefani and M. Cereijido. Occluding junctions in MDCK cells: Modulation of transepithelial permeability by the cytoskeleton. J. Cell Biochem. 18: 407–421 (1982). J.L. Madara. Intestinal absorptive cell tight junctions are linked to cytoskeleton. Am J. Physiol. 253: C171–C175 (1987). E.K. Anderberg, T. Lindmark and P. Artursson. Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharm. Res. 10: 857–864 (1993) D.N. Granger, P.R. Kvietys, M.A. Perry and A.E. Taylor. Charge selectivity of rat intestinal capillaries. Gastroenterology. 91: 1443–1446 (1986). S.M. Siegel and O. Daly. Regulation of betacyanin efflux from beet root by poly-1-lysine, Ca-ion and other substances. Plant Physiol. 41: 1429–1434 (1966). J.L. Madara. Loosening tight junctions. J. Clin. Invest.. 83: 1089–1094 (1989).