Nuclear or cytoplasmic expression of survivin: What is the significance?
Tóm tắt
Growing evidence suggests that survivin expression in cancer cell nuclei may represent an important prognostic marker to predict disease outcome for cancer patients. Current reports in this research area, however, are inconsistent and propose opposing conclusions regarding the significance and prognostic value of survivin nuclear expression. The aim of our study is to review and discuss the data reported in the original publications. We have also provided new experimental data to support our view regarding the possible reasons for the observed inconsistencies in the literature. This would alert researchers to pay attention to potential pitfalls in the determination of nuclear or cytoplasmic expression of survivin for the future. © 2004 Wiley‐Liss, Inc.
Từ khóa
Tài liệu tham khảo
Javle MM, 2004, Nuclear survivin expression predicts poor outcome in cholangiocarcinoma, Hepatogastroenterology, 51, 1653
Takai N, 2002, Expression of survivin is associated with malignant potential in epithelial ovarian carcinoma, Int J Mol Med, 10, 211
Mahotka C, 1999, Survivin‐deltaEx3 and survivin‐2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties, Cancer Res, 59, 6097