Nuclear or cytoplasmic expression of survivin: What is the significance?

International Journal of Cancer - Tập 114 Số 4 - Trang 509-512 - 2005
Fengzhi Li1, Jie Yang, Nithya Ramnath, Milind Javle, Dongfeng Tan
1Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. [email protected]

Tóm tắt

AbstractGrowing evidence suggests that survivin expression in cancer cell nuclei may represent an important prognostic marker to predict disease outcome for cancer patients. Current reports in this research area, however, are inconsistent and propose opposing conclusions regarding the significance and prognostic value of survivin nuclear expression. The aim of our study is to review and discuss the data reported in the original publications. We have also provided new experimental data to support our view regarding the possible reasons for the observed inconsistencies in the literature. This would alert researchers to pay attention to potential pitfalls in the determination of nuclear or cytoplasmic expression of survivin for the future. © 2004 Wiley‐Liss, Inc.

Từ khóa


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Thông tin
Thông tin xuất bản

International Journal of Cancer

Tập 114 Số 4

509-512

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