Pasteurella multocida septic shock following liver transplantation treated with drotrecogin alfa (activated)

Transplant Infectious Disease - Tập 9 Số 3 - Trang 233-236 - 2007
Salman Al‐Sabah1, Paul Goldberg2,3, Salman T. Qureshi2,3
1Department of Surgery
2Department of Medicine
3Division of Critical Care Medicine, McGill University, Montreal, Quebec, Canada

Tóm tắt

Abstract: Severe sepsis and progression to septic shock in solid organ transplant recipients is associated with a high mortality. We describe a fulminant case of septic shock in a liver transplant recipient caused by Pasteurella multocida, a gram‐negative coccobacillus most commonly associated with domestic cats and dogs. P. multocida is a rare cause of bacteremia and has not been reported as a cause of septic shock following liver transplantation. In addition to standard therapy, the patient was managed with drotrecogin alfa (activated) recombinant activated protein C (APC), an evidence‐based agent that has been shown to significantly improve outcome in severe sepsis in the non‐transplant population. The known risk factors, clinical course, and outcomes of severe infection associated with P. multocida are also briefly reviewed. This case illustrates the need for transplant recipients and their healthcare providers to carefully consider the risk of severe infection associated with domestic animal exposure.

Từ khóa


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Transplant Infectious Disease

Tập 9 Số 3

233-236

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