Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice

Blood - Tập 129 - Trang 1357-1367 - 2017
Braedon McDonald1,2, Rachelle P. Davis2,3, Seok-Joo Kim2,3, Mandy Tse2,3, Charles T. Esmon4, Elzbieta Kolaczkowska5, Craig N. Jenne1,2,3
1Department of Critical Care Medicine, University of Calgary, Calgary, AB, Canada
2Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada
3Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, AB, Canada
4Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, OK
5Department of Evolutionary Immunology, Institute of Zoology, Jagiellonian University, Krakow, Poland

Tóm tắt

Key Points In vivo imaging reveals a NET–platelet–thrombin axis that promotes intravascular coagulation in sepsis. Inhibition of NETs during sepsis reduces intravascular coagulation, improves microvascular perfusion, and reduces organ damage.

Tài liệu tham khảo

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