Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases
Tóm tắt
Từ khóa
Tài liệu tham khảo
Gorgoulis, 2019, Cellular senescence: Defining a path forward, Cell, 179, 813, 10.1016/j.cell.2019.10.005
Milanovic, 2018, Senescence-associated reprogramming promotes cancer stemness, Nature, 553, 96, 10.1038/nature25167
Liu, 2015, Impact of er stress-regulated atf4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy, Am. J. Physiol. Cell Physiol., 308, C621, 10.1152/ajpcell.00096.2014
Mao, 2012, Replicatively senescent cells are arrested in g1 and g2 phases, Aging, 4, 431, 10.18632/aging.100467
Burton, 2014, Physiological and pathological consequences of cellular senescence, Cell Mol. Life Sci., 71, 4373, 10.1007/s00018-014-1691-3
Lin, 2010, Skp2 targeting suppresses tumorigenesis by arf-p53-independent cellular senescence, Nature, 464, 374, 10.1038/nature08815
Braig, 2005, Oncogene-induced senescence as an initial barrier in lymphoma development, Nature, 436, 660, 10.1038/nature03841
Canamero, 2013, Programmed cell senescence during mammalian embryonic development, Cell, 155, 1104, 10.1016/j.cell.2013.10.019
Demaria, 2014, An essential role for senescent cells in optimal wound healing through secretion of pdgf-aa, Dev. Cell, 31, 722, 10.1016/j.devcel.2014.11.012
Helman, 2016, P16(ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion, Nat. Med., 22, 412, 10.1038/nm.4054
Baker, 2016, Naturally occurring p16(ink4a)-positive cells shorten healthy lifespan, Nature, 530, 184, 10.1038/nature16932
Childs, 2015, Cellular senescence in aging and age-related disease: From mechanisms to therapy, Nat. Med., 21, 1424, 10.1038/nm.4000
Baker, 2011, Clearance of p16ink4a-positive senescent cells delays ageing-associated disorders, Nature, 479, 232, 10.1038/nature10600
Childs, 2017, Senescent cells: An emerging target for diseases of ageing, Nat. Rev. Drug Discov., 16, 718, 10.1038/nrd.2017.116
Shakeri, 2018, Cellular senescence links aging and diabetes in cardiovascular disease, Am. J. Physiol. Heart Circ. Physiol., 315, H448, 10.1152/ajpheart.00287.2018
Fyhrquist, 2013, The roles of senescence and telomere shortening in cardiovascular disease, Nat. Rev. Cardiol., 10, 274, 10.1038/nrcardio.2013.30
Baker, 2018, Cellular senescence in brain aging and neurodegenerative diseases: Evidence and perspectives, J. Clin. Investig., 128, 1208, 10.1172/JCI95145
Bussian, 2018, Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline, Nature, 562, 578, 10.1038/s41586-018-0543-y
Jeon, 2018, Senescent cells and osteoarthritis: A painful connection, J. Clin. Investig., 128, 1229, 10.1172/JCI95147
Krizhanovsky, 2008, Senescence of activated stellate cells limits liver fibrosis, Cell, 134, 657, 10.1016/j.cell.2008.06.049
Jun, 2010, The matricellular protein ccn1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing, Nat. Cell Biol., 12, 676, 10.1038/ncb2070
Tilstra, 2012, Nf-kappab inhibition delays DNA damage-induced senescence and aging in mice, J. Clin. Investig., 122, 2601, 10.1172/JCI45785
Kang, 2015, The DNA damage response induces inflammation and senescence by inhibiting autophagy of gata4, Science, 349, aaa5612, 10.1126/science.aaa5612
Fumagalli, 2006, Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication, Nature, 444, 638, 10.1038/nature05327
Wiley, 2016, Mitochondrial dysfunction induces senescence with a distinct secretory phenotype, Cell Metab., 23, 303, 10.1016/j.cmet.2015.11.011
Campisi, 2019, From discoveries in ageing research to therapeutics for healthy ageing, Nature, 571, 183, 10.1038/s41586-019-1365-2
Mammoto, 2019, Effects of age-dependent changes in cell size on endothelial cell proliferation and senescence through yap1, Aging, 11, 7051, 10.18632/aging.102236
Buchwalter, 2017, Nucleolar expansion and elevated protein translation in premature aging, Nat. Commun., 8, 328, 10.1038/s41467-017-00322-z
Tiku, 2017, Small nucleoli are a cellular hallmark of longevity, Nat. Commun., 8, 16083, 10.1038/ncomms16083
Matthews, 2006, Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: Effects of telomerase and oxidative stress, Circ. Res., 99, 156, 10.1161/01.RES.0000233315.38086.bc
Ding, 2016, Absence of ampkalpha2 accelerates cellular senescence via p16 induction in mouse embryonic fibroblasts, Int. J. Biochem. Cell Biol., 71, 72, 10.1016/j.biocel.2015.12.010
Morgan, 2013, Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries, Am. J. Physiol. Heart Circ. Physiol., 305, H251, 10.1152/ajpheart.00197.2013
Coppe, 2006, Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence, J. Biol. Chem., 281, 29568, 10.1074/jbc.M603307200
Severino, 2013, Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells, Cell Death Dis., 4, e911, 10.1038/cddis.2013.445
Gluck, 2017, Innate immune sensing of cytosolic chromatin fragments through cgas promotes senescence, Nat. Cell Biol., 19, 1061, 10.1038/ncb3586
Yosef, 2016, Directed elimination of senescent cells by inhibition of bcl-w and bcl-xl, Nat. Commun., 7, 11190, 10.1038/ncomms11190
Evangelou, 2017, Robust, universal biomarker assay to detect senescent cells in biological specimens, Aging Cell., 16, 192, 10.1111/acel.12545
Ahadi, 2020, Personal aging markers and ageotypes revealed by deep longitudinal profiling, Nat. Med., 26, 83, 10.1038/s41591-019-0719-5
Ovadya, 2018, Impaired immune surveillance accelerates accumulation of senescent cells and aging, Nat. Commun., 9, 5435, 10.1038/s41467-018-07825-3
Dent, 2016, Frailty measurement in research and clinical practice: A review, Eur. J. Intern. Med., 31, 3, 10.1016/j.ejim.2016.03.007
Das, 2018, Impairment of an endothelial nad(+)-h2s signaling network is a reversible cause of vascular aging, Cell, 173, 74, 10.1016/j.cell.2018.02.008
Mattis, 2016, Circadian rhythms, sleep, and disorders of aging, Trends Endocrinol. Metab., 27, 192, 10.1016/j.tem.2016.02.003
Field, 2018, DNA methylation clocks in aging: Categories, causes, and consequences, Mol. Cell., 71, 882, 10.1016/j.molcel.2018.08.008
Justice, 2019, Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study, EBioMedicine, 40, 554, 10.1016/j.ebiom.2018.12.052
Ng, 2015, Markers of t-cell senescence and physical frailty: Insights from singapore longitudinal ageing studies, NPJ Aging Mechan. Dis., 1, 15005, 10.1038/npjamd.2015.5
Childs, 2016, Senescent intimal foam cells are deleterious at all stages of atherosclerosis, Science, 354, 472, 10.1126/science.aaf6659
Chen, 2016, Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm, Circ. Res., 119, 1076, 10.1161/CIRCRESAHA.116.308895
Watson, 2017, Nicotinamide phosphoribosyltransferase in smooth muscle cells maintains genome integrity, resists aortic medial degeneration, and is suppressed in human thoracic aortic aneurysm disease, Circ. Res., 120, 1889, 10.1161/CIRCRESAHA.116.310022
Roos, 2016, Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice, Aging Cell, 15, 973, 10.1111/acel.12458
Gude, 2018, Cardiac ageing: Extrinsic and intrinsic factors in cellular renewal and senescence, Nat. Rev. Cardiol., 15, 523, 10.1038/s41569-018-0061-5
Bochenek, 2016, Endothelial cell senescence and thrombosis: Ageing clots, Thromb. Res., 147, 36, 10.1016/j.thromres.2016.09.019
Pantsulaia, 2016, Senescent endothelial cells: Potential modulators of immunosenescence and ageing, Ageing Res. Rev., 29, 13, 10.1016/j.arr.2016.05.011
Wang, 2015, Vascular smooth muscle cell senescence promotes atherosclerosis and features of plaque vulnerability, Circulation, 132, 1909, 10.1161/CIRCULATIONAHA.115.016457
Kritsilis, M., V Rizou, R., Koutsoudaki, P.N., Evangelou, K., Gorgoulis, V.G., and Papadopoulos, D. (2018). Ageing, cellular senescence and neurodegenerative disease. Int. J. Mol. Sci., 19.
Zhang, 2019, Senolytic therapy alleviates aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an alzheimer’s disease model, Nat. Neurosci., 22, 719, 10.1038/s41593-019-0372-9
Chinta, 2018, Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to parkinson’s disease, Cell Rep., 22, 930, 10.1016/j.celrep.2017.12.092
Golomb, 2015, Age-associated inflammation connects ras-induced senescence to stem cell dysfunction and epidermal malignancy, Cell Death Differ., 22, 1764, 10.1038/cdd.2015.21
Justice, 2018, Cellular senescence biomarker p16ink4a+ cell burden in thigh adipose is associated with poor physical function in older women, J. Gerontol. A Biol. Sci. Med. Sci., 73, 939, 10.1093/gerona/glx134
Xu, 2018, Senolytics improve physical function and increase lifespan in old age, Nat. Med., 24, 1246, 10.1038/s41591-018-0092-9
Sawaki, 2018, Visceral adipose tissue drives cardiac aging through modulation of fibroblast senescence by osteopontin production, Circulation, 138, 809, 10.1161/CIRCULATIONAHA.117.031358
Lefranc, 2019, Mr (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity, Hypertension, 73, 458, 10.1161/HYPERTENSIONAHA.118.11873
Berry, 2017, Cellular aging contributes to failure of cold-induced beige adipocyte formation in old mice and humans, Cell Metab., 25, 166, 10.1016/j.cmet.2016.10.023
Thompson, 2019, Targeted elimination of senescent beta cells prevents type 1 diabetes, Cell Metab., 29, 1045, 10.1016/j.cmet.2019.01.021
Andle, 2019, Acceleration of beta cell aging determines diabetes and senolysis improves disease outcomes, Cell Metab., 30, 129, 10.1016/j.cmet.2019.05.006
Ruchaya, 2019, Aged-senescent cells contribute to impaired heart regeneration, Aging Cell, 18, e12931, 10.1111/acel.12931
Anderson, 2019, Length-independent telomere damage drives post-mitotic cardiomyocyte senescence, EMBO J., 38, e100492, 10.15252/embj.2018100492
Walaszczyk, 2019, Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction, Aging Cell, 18, e12945, 10.1111/acel.12945
Chimenti, 2003, Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure, Circ. Res., 93, 604, 10.1161/01.RES.0000093985.76901.AF
Moncsek, 2018, Targeting senescent cholangiocytes and activated fibroblasts with b-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (mdr2(-/-)) mice, Hepatology, 67, 247, 10.1002/hep.29464
Sessions, 2019, Controlled induction and targeted elimination of p16(ink4a)-expressing chondrocytes in cartilage explant culture, FASEB J., 33, 12364, 10.1096/fj.201900815RR
Minamino, 2002, Endothelial cell senescence in human atherosclerosis: Role of telomere in endothelial dysfunction, Circulation, 105, 1541, 10.1161/01.CIR.0000013836.85741.17
Durik, 2012, Nucleotide excision DNA repair is associated with age-related vascular dysfunction, Circulation, 126, 468, 10.1161/CIRCULATIONAHA.112.104380
Gevaert, 2017, Endothelial senescence contributes to heart failure with preserved ejection fraction in an aging mouse model, Circ. Heart Fail., 10, e003806, 10.1161/CIRCHEARTFAILURE.116.003806
Sugawara, 2005, Decrease and senescence of endothelial progenitor cells in patients with preeclampsia, J. Clin. Endocrinol. Metab., 90, 5329, 10.1210/jc.2005-0532
Xu, 2015, Targeting senescent cells enhances adipogenesis and metabolic function in old age, Elife, 4, e12997, 10.7554/eLife.12997
Yousefzadeh, 2018, Fisetin is a senotherapeutic that extends health and lifespan, EBioMedicine, 36, 18, 10.1016/j.ebiom.2018.09.015
Pietrocola, 2019, Identification and characterization of cardiac glycosides as senolytic compounds, Nat. Commun., 10, 4731, 10.1038/s41467-019-12888-x
Schafer, 2017, Cellular senescence mediates fibrotic pulmonary disease, Nat. Commun., 8, 14532, 10.1038/ncomms14532
Valin, 2019, Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype, Immun. Ageing., 16, 29, 10.1186/s12979-019-0169-4
Ogrodnik, 2019, Obesity-induced cellular senescence drives anxiety and impairs neurogenesis, Cell Metab., 29, 1061, 10.1016/j.cmet.2018.12.008
Chang, 2016, Clearance of senescent cells by abt263 rejuvenates aged hematopoietic stem cells in mice, Nat. Med., 22, 78, 10.1038/nm.4010
Suematsu, 2001, Professor toshio ito: A clairvoyant in pericyte biology, Keio J. Med., 50, 66, 10.2302/kjm.50.66
Ogrodnik, 2017, Cellular senescence drives age-dependent hepatic steatosis, Nat. Commun., 8, 15691, 10.1038/ncomms15691
Victorelli, 2019, Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction, EMBO J., 38, e101982, 10.15252/embj.2019101982
Meyer, 2016, Essential role for premature senescence of myofibroblasts in myocardial fibrosis, J. Am. Coll. Cardiol., 67, 2018, 10.1016/j.jacc.2016.02.047
Nicaise, 2019, Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis, Proc. Natl. Acad. Sci. USA, 116, 9030, 10.1073/pnas.1818348116
Farr, 2017, Targeting cellular senescence prevents age-related bone loss in mice, Nat. Med., 23, 1072, 10.1038/nm.4385
Yi, 2019, T-cell senescence contributes to abnormal glucose homeostasis in humans and mice, Cell Death Dis., 10, 249, 10.1038/s41419-019-1494-4
Lasko, 2004, Aging exacerbates neointimal formation, and increases proliferation and reduces susceptibility to apoptosis of vascular smooth muscle cells in mice, J. Vasc. Surg., 40, 1199, 10.1016/j.jvs.2004.08.034
Mills, 2016, Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice, Cell Metab., 24, 795, 10.1016/j.cmet.2016.09.013
Song, 2017, Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases, Cell Mol. Life Sci., 74, 2899, 10.1007/s00018-017-2504-2
Yoshino, 2018, Nad(+) intermediates: The biology and therapeutic potential of nmn and nr, Cell Metab., 27, 513, 10.1016/j.cmet.2017.11.002
Zhang, 2016, Nad(+) repletion improves mitochondrial and stem cell function and enhances life span in mice, Science, 352, 1436, 10.1126/science.aaf2693
Irie, 2020, Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy japanese men, Endocr. J., 67, 153, 10.1507/endocrj.EJ19-0313
Latorre, 2018, Mitochondria-targeted hydrogen sulfide attenuates endothelial senescence by selective induction of splicing factors hnrnpd and srsf2, Aging, 10, 1666, 10.18632/aging.101500
Zivanovic, 2019, Selective persulfide detection reveals evolutionarily conserved antiaging effects of s-sulfhydration, Cell Metab., 30, 1152, 10.1016/j.cmet.2019.10.007
Zhang, X., Chen, W., Gao, Q., Yang, J., Yan, X., Zhao, H., Su, L., Yang, M., Gao, C., and Yao, Y. (2019). Rapamycin directly activates lysosomal mucolipin trp channels independent of mtor. PLoS Biol., 17.
Harrison, 2009, Rapamycin fed late in life extends lifespan in genetically heterogeneous mice, Nature, 460, 392, 10.1038/nature08221
Flynn, 2013, Late-life rapamycin treatment reverses age-related heart dysfunction, Aging Cell., 12, 851, 10.1111/acel.12109
Mannick, 2018, Torc1 inhibition enhances immune function and reduces infections in the elderly, Sci. Transl. Med., 10, eaaq1564, 10.1126/scitranslmed.aaq1564
Chung, 2019, Topical rapamycin reduces markers of senescence and aging in human skin: An exploratory, prospective, randomized trial, Geroscience, 41, 861, 10.1007/s11357-019-00113-y
Barzilai, 2016, Metformin as a tool to target aging, Cell Metab., 23, 1060, 10.1016/j.cmet.2016.05.011
Soukas, 2019, Metformin as anti-aging therapy: Is it for everyone?, Trends Endocrinol. Metab., 30, 745, 10.1016/j.tem.2019.07.015
Moiseeva, 2013, Metformin inhibits the senescence-associated secretory phenotype by interfering with ikk/nf-kappab activation, Aging Cell, 12, 489, 10.1111/acel.12075
Onken, B., and Driscoll, M. (2010). Metformin induces a dietary restriction-like state and the oxidative stress response to extend c. Elegans healthspan via ampk, lkb1, and skn-1. PLoS ONE, 5.
Cabreiro, 2013, Metformin retards aging in c. Elegans by altering microbial folate and methionine metabolism, Cell, 153, 228, 10.1016/j.cell.2013.02.035
Pryor, 2019, Host-microbe-drug-nutrient screen identifies bacterial effectors of metformin therapy, Cell, 178, 1299, 10.1016/j.cell.2019.08.003
Kulkarni, 2018, Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults, Aging Cell, 17, e12723, 10.1111/acel.12723
Espinoza, 2020, Rationale and study design of a randomized clinical trial of metformin to prevent frailty in older adults with prediabetes, J. Gerontol. A Biol. Sci. Med. Sci., 75, 102, 10.1093/gerona/glz078
Konopka, 2019, Taming expectations of metformin as a treatment to extend healthspan, GeroScience, 41, 101, 10.1007/s11357-019-00057-3
Roberts, 2017, A ketogenic diet extends longevity and healthspan in adult mice, Cell Metab., 26, 539, 10.1016/j.cmet.2017.08.005
Newman, 2017, Ketogenic diet reduces midlife mortality and improves memory in aging mice, Cell Metab., 26, 547, 10.1016/j.cmet.2017.08.004
Mattson, 2019, Effects of intermittent fasting on health, aging, and disease, N. Engl. J. Med., 381, 2541, 10.1056/NEJMra1905136
Sleiman, 2016, Exercise promotes the expression of brain derived neurotrophic factor (bdnf) through the action of the ketone body beta-hydroxybutyrate, Elife, 5, e15092, 10.7554/eLife.15092
Youm, 2015, The ketone metabolite beta-hydroxybutyrate blocks nlrp3 inflammasome-mediated inflammatory disease, Nat. Med., 21, 263, 10.1038/nm.3804
Han, 2018, Beta-hydroxybutyrate prevents vascular senescence through hnrnp a1-mediated upregulation of oct4, Mol. Cell., 71, 1064, 10.1016/j.molcel.2018.07.036
Zhang, 2020, Ketogenesis-generated beta-hydroxybutyrate is an epigenetic regulator of cd8(+) t-cell memory development, Nat. Cell Biol., 22, 18, 10.1038/s41556-019-0440-0
Hickson, 2019, Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease, EBioMedicine, 47, 446, 10.1016/j.ebiom.2019.08.069
Ovadya, 2018, Strategies targeting cellular senescence, J. Clin. Investig., 128, 1247, 10.1172/JCI95149
Prata, 2018, Senescent cell clearance by the immune system: Emerging therapeutic opportunities, Semin. Immunol., 40, 101275, 10.1016/j.smim.2019.04.003
Zhao, 2020, A gpr174-ccl21 module imparts sexual dimorphism to humoral immunity, Nature, 577, 416, 10.1038/s41586-019-1873-0
Pereira, 2019, Senescent cells evade immune clearance via hla-e-mediated nk and cd8(+) t cell inhibition, Nat. Commun., 10, 2387, 10.1038/s41467-019-10335-5
Lages, 2008, Functional regulatory t cells accumulate in aged hosts and promote chronic infectious disease reactivation, J. Immunol., 181, 1835, 10.4049/jimmunol.181.3.1835
Rosenkranz, 2007, Higher frequency of regulatory t cells in the elderly and increased suppressive activity in neurodegeneration, J. Neuroimmunol., 188, 117, 10.1016/j.jneuroim.2007.05.011
Hashimoto, 2019, Single-cell transcriptomics reveals expansion of cytotoxic cd4 t cells in supercentenarians, Proc. Natl. Acad. Sci. USA, 116, 24242, 10.1073/pnas.1907883116
Weiskopf, 2015, Dengue virus infection elicits highly polarized cx3cr1+ cytotoxic cd4+ t cells associated with protective immunity, Proc. Natl. Acad. Sci. USA, 112, E4256, 10.1073/pnas.1505956112
Quezada, 2010, Tumor-reactive cd4(+) t cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts, J. Exp. Med., 207, 637, 10.1084/jem.20091918
Kang, 2011, Senescence surveillance of pre-malignant hepatocytes limits liver cancer development, Nature, 479, 547, 10.1038/nature10599
Sagiv, 2013, Granule exocytosis mediates immune surveillance of senescent cells, Oncogene, 32, 1971, 10.1038/onc.2012.206
Burton, 2018, Cellular senescence: Immunosurveillance and future immunotherapy, Ageing Res. Rev., 43, 17, 10.1016/j.arr.2018.02.001
Hoenicke, 2012, Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies, Carcinogenesis, 33, 1123, 10.1093/carcin/bgs124
Aghajanian, 2019, Targeting cardiac fibrosis with engineered t cells, Nature, 573, 430, 10.1038/s41586-019-1546-z
Egashira, 2017, F4/80+ macrophages contribute to clearance of senescent cells in the mouse postpartum uterus, Endocrinology, 158, 2344, 10.1210/en.2016-1886
Brighton, 2017, Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium, Elife, 6, e31274, 10.7554/eLife.31274
Soriani, 2009, Atm-atr-dependent up-regulation of dnam-1 and nkg2d ligands on multiple myeloma cells by therapeutic agents results in enhanced nk-cell susceptibility and is associated with a senescent phenotype, Blood, 113, 3503, 10.1182/blood-2008-08-173914
Roberts, 2017, Tissue-resident macrophages are locally programmed for silent clearance of apoptotic cells, Immunity, 47, 913, 10.1016/j.immuni.2017.10.006
Proto, 2018, Regulatory t cells promote macrophage efferocytosis during inflammation resolution, Immunity, 49, 666, 10.1016/j.immuni.2018.07.015
Schrijvers, 2005, Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis, Arterioscler. Thromb. Vasc. Biol., 25, 1256, 10.1161/01.ATV.0000166517.18801.a7
Kojima, 2017, The role of efferocytosis in atherosclerosis, Circulation, 135, 476, 10.1161/CIRCULATIONAHA.116.025684
Seneviratne, 2017, Interferon regulatory factor 5 controls necrotic core formation in atherosclerotic lesions by impairing efferocytosis, Circulation, 136, 1140, 10.1161/CIRCULATIONAHA.117.027844
Thorp, 2008, Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice, Arterioscler. Thromb. Vasc. Biol., 28, 1421, 10.1161/ATVBAHA.108.167197
Yurdagul, 2017, Mechanisms and consequences of defective efferocytosis in atherosclerosis, Front. Cardiovasc Med., 4, 86, 10.3389/fcvm.2017.00086
Xue, 2007, Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas, Nature, 445, 656, 10.1038/nature05529
Yang, 2018, C-type lectin receptor lsectin-mediated apoptotic cell clearance by macrophages directs intestinal repair in experimental colitis, Proc. Natl. Acad. Sci. USA, 115, 11054, 10.1073/pnas.1804094115
Wang, 2017, Mitochondrial fission promotes the continued clearance of apoptotic cells by macrophages, Cell, 171, 331, 10.1016/j.cell.2017.08.041
Kojima, 2016, Cd47-blocking antibodies restore phagocytosis and prevent atherosclerosis, Nature, 536, 86, 10.1038/nature18935
Kojima, 2014, Cyclin-dependent kinase inhibitor 2b regulates efferocytosis and atherosclerosis, J. Clin. Investig., 124, 1083, 10.1172/JCI70391
Gardai, 2005, Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of lrp on the phagocyte, Cell, 123, 321, 10.1016/j.cell.2005.08.032
Sagiv, 2016, Nkg2d ligands mediate immunosurveillance of senescent cells, Aging, 8, 328, 10.18632/aging.100897
Radaeva, 2006, Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in nkg2d-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners, Gastroenterology, 130, 435, 10.1053/j.gastro.2005.10.055
Iannello, 2013, P53-dependent chemokine production by senescent tumor cells supports nkg2d-dependent tumor elimination by natural killer cells, J. Exp. Med., 210, 2057, 10.1084/jem.20130783
Andre, 2018, Anti-nkg2a mab is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both t and nk cells, Cell, 175, 1731, 10.1016/j.cell.2018.10.014
Kamiya, 2019, Blocking expression of inhibitory receptor nkg2a overcomes tumor resistance to nk cells, J. Clin. Investig., 129, 2094, 10.1172/JCI123955
Lynn, 2019, C-jun overexpression in car t cells induces exhaustion resistance, Nature, 576, 293, 10.1038/s41586-019-1805-z
Kay, 1993, Generation of senescent cell antigen on old cells initiates igg binding to a neoantigen, Cell Mol. Biol., 39, 131
Baumeister, 2019, Phase i trial of autologous car t cells targeting nkg2d ligands in patients with aml/mds and multiple myeloma, Cancer Immunol. Res., 7, 100, 10.1158/2326-6066.CIR-18-0307
Albert, 1998, Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and cd36, and cross-present antigens to cytotoxic t lymphocytes, J. Exp. Med., 188, 1359, 10.1084/jem.188.7.1359
Cummings, 2016, Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs, Nature, 539, 565, 10.1038/nature20138
Clement, 2019, Impaired autophagy in cd11b(+) dendritic cells expands cd4(+) regulatory t cells and limits atherosclerosis in mice, Circ. Res., 125, 1019, 10.1161/CIRCRESAHA.119.315248
Yun, 2016, Indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory t cells, Cell Metab., 23, 852, 10.1016/j.cmet.2016.04.010