Nanoscale biogenic iron oxides and neurodegenerative disease

FEBS Letters - Tập 496 - Trang 1-5 - 2001
Jon Dobson1
1Centre for Science and Technology in Medicine, Department of Biomedical Engineering and Medical Physics, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK

Tóm tắt

One of the characteristics of many neurodegenerative diseases is the disruption of normal iron homeostasis in the brain. Recent experimental work indicates that nanoscale magnetic biominerals (primarily magnetite and maghemite) may be associated with senile plaques and tau filaments found in brain tissue affected by these diseases. These findings have important implications for our understanding of the role of iron in neurodegenerative disease as well as profound implications for their causes. In addition, the presence of biogenic magnetite in affected tissue should also provide improved mechanisms for early detection through the modification of MRI pulse sequences.

Tài liệu tham khảo

10.1016/S0022-510X(98)00092-6 10.1111/j.1753-4887.1993.tb03096.x 10.1016/S0024-3205(97)00282-8 10.1046/j.1471-4159.1995.65020710.x 10.1016/S0891-5849(96)00629-6 10.1016/0022-510X(95)00206-H 10.1073/pnas.94.18.9866 10.1046/j.1471-4159.2000.0740270.x Perez M., 1998, Pm. J. Pathol., 152, 1531 10.1111/j.1471-4159.1993.tb03639.x 10.1002/ana.410320713 Floor E., 2000, Cell. Mol. Biol., 46, 709 Bartzokis G., 2000, Cell. Mol. Biol., 46, 821 Shoham S., 2000, Cell. Mol. Biol., 46, 743 10.1084/jem.185.9.1565 10.1074/jbc.C000165200 10.1093/jnen/59.11.1011 10.1073/pnas.89.16.7683 10.1016/0361-9230(95)02132-9 10.1016/0361-9230(94)00182-Z 10.1016/S0304-4165(98)00160-3 10.1023/A:1009271111083 10.1002/bem.2250130710 Kobayashi A. and J.L. Kirschvink (1995) in: Electromagnetic Fields: Biological Interactions and Mechanisms (M. Blank Ed.) Advances in Chemistry Series No. 250 pp. 367–394 American Chemical Society Washington DC. 10.1126/science.282.5395.1868 10.1016/S0925-4439(99)00104-0 10.1016/0005-2728(96)00022-9 Quintana C., 2000, Cell. Mol. Biol., 46, 807 Cornett C.R., 1998, Neurotoxicology, 19, 339 Chignell C.F., 1998, Photochem. Photobiol., 65, 598 10.1111/j.1751-1097.1997.tb01921.x Schafer F.Q., 2000, Cell. Mol. Biol., 46, 657 10.1080/00268979809483134 10.1080/095530096146147 10.1016/S0006-8993(99)01694-7 10.1016/0022-510X(96)00169-4 10.1016/0022-510X(95)00205-G 10.1016/S0925-4927(98)00018-3 10.1212/WNL.45.6.1138 10.1148/radiology.173.2.2798884 10.1002/mrm.1910310305 10.1016/S0304-8853(98)00578-2 10.1016/S0730-725X(00)00118-1
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FEBS Letters

Tập 496

1-5

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