Ribosome‐inactivating lectins with polynucleotide:adenosine glycosidase activity

FEBS Letters - Tập 408 - Trang 355-359 - 1997
Maria Giulia Battelli1, Luigi Barbieri1, Andrea Bolognesi1, Laura Buonamici1, Paola Valbonesi1, Letizia Polito1, Els J.M Van Damme2, Willy J Peumans2, Fiorenzo Stirpe1
1Dipartimento di Patologia sperimentale dell'Università di Bologna, Via S. Giacomo 14, I-40126 Bologna, Italy
2Laboratory for Phytopathology and Plant Protection, Katholieke Universiteit Leuven, Willem de Croylaan 42, B-3001 Leuven, Belgium

Tóm tắt

Lectins from Aegopodium podagraria (APA), Bryonia dioica (BDA), Galanthus nivalis (GNA), Iris hybrid (IRA) and Sambucus nigra (SNAl), and a new lectin‐related protein from Sambucus nigra (SNLRP) were studied to ascertain whether they had the properties of ribosome‐inactivating proteins (RIP). IRA and SNLRP inhibited protein synthesis by a cell‐free system and, at much higher concentrations, by cells and had polynucleotide:adenosine glycosidase activity, thus behaving like non‐toxic type 2 (two chain) RIP. APA and SNAl had much less activity, and BDA and GNA did not inhibit protein synthesis.

Tài liệu tham khảo

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FEBS Letters

Tập 408

355-359

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