Widespread expression of beta‐defensin hBD‐1 in human secretory glands and epithelial cells

FEBS Letters - Tập 396 - Trang 319-322 - 1996
Chengquan Zhao1, Ingrid Wang1, Robert I. Lehrer1,2
1Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA
2Molecular Biology Institute, UCLA School of Medicine, Los Angeles, CA 90095-1690, USA

Tóm tắt

We compared the expression of human α‐ and β‐defensins by various human tissues. mRNA for α‐defensins HNP1‐3, abundant in bone marrow, was detected in peripheral blood leukocytes, spleen and thymus by RT‐PCR, which revealed α‐defensins HD5 and HD6 only in the small intestine. In contrast, the pancreas and kidney expressed high levels of hBD‐1 and lower levels of this β‐defensin were found in many organs by RT‐PCR (salivary gland > trachea > prostate and placenta > thymus, testis, small intestine). hBD‐1 mRNA was produced constitutively by cultured normal human epithelial cells derived from the trachea, bronchi, small airways and the mammary gland. These largely non‐overlapping tissue distributions of human α‐ and β‐defensins suggest that hBD‐1 may be positioned to defend epithelial cells and mucosae from infection, whereas expression of HNP1‐3 in neutrophils and HD5 and HD6 in Paneth cells allows these α‐defensins to participate in systemic and small intestinal host defenses, respectively.

Tài liệu tham khảo

10.1016/0952-7915(94)90145-7 10.1016/S0021-9258(18)53298-1 10.1016/S0021-9258(18)53299-3 10.1016/0014-5793(94)80517-2 10.1002/jlb.56.5.661 1993 G. Diamond D.E. Jones C.L. Bevins Proc. Natl. Acad. Sci. USA 4596 4600 10.1126/science.7886453 10.1073/pnas.86.23.9159 10.1016/S0021-9258(18)50079-X 10.1016/0014-5793(93)81160-2 10.1074/jbc.271.8.4038 10.1016/0014-5793(95)00687-5 Liu L., 1996, J. Invest. Med., 44, 294A 10.1128/iai.64.5.1565-1568.1996 1996 G. Diamond J.P. Russell C.L. Bevins Proc. Natl. Acad. Sci. USA 1988 K.A. Daher R.I. Lehrer T. Ganz M. Kronenberg Proc. Natl. Acad. Sci. USA 7327 7331 Valore E., 1996, J. Invest. Med., 44, 268A 10.1002/path.1711180308 10.1097/00006676-199309000-00003 Gudmundsson G.H., 1996, FEBS., 238, 325 10.1128/iai.63.4.1291-1297.1995
Thông tin
Thông tin xuất bản

FEBS Letters

Tập 396

319-322

Thông tin tác giả