Convex optimized diffusion encoding (CODE) gradient waveforms for minimum echo time and bulk motion–compensated diffusion‐weighted MRI

Magnetic Resonance in Medicine - Tập 77 Số 2 - Trang 717-729 - 2017
Eric Aliotta1,2, Holden H. Wu1,2, Daniel B. Ennis1,2
1Biomedical Physics Interdepartmental Program, University of California, Los Angeles, California, USA.
2Department of Radiological Sciences, University of California, Los Angeles, California, USA

Tóm tắt

PurposeTo evaluate convex optimized diffusion encoding (CODE) gradient waveforms for minimum echo time and bulk motion–compensated diffusion‐weighted imaging (DWI).MethodsDiffusion‐encoding gradient waveforms were designed for a range of b‐values and spatial resolutions with and without motion compensation using the CODE framework. CODE, first moment (M1) nulled CODE‐M1, and first and second moment (M2) nulled CODE‐M1M2 were used to acquire neuro, liver, and cardiac ADC maps in healthy subjects (n=10) that were compared respectively to monopolar (MONO), BIPOLAR (M1 = 0), and motion‐compensated (MOCO, M1 + M2 = 0) diffusion encoding.ResultsCODE significantly improved the SNR of neuro ADC maps compared with MONO (19.5 ± 2.5 versus 14.5 ± 1.9). CODE‐M1 liver ADCs were significantly lower (1.3 ± 0.1 versus 1.8 ± 0.3 × 10−3 mm2/s, ie, less motion corrupted) and more spatially uniform (6% versus 55% ROI difference) than MONO and had higher SNR than BIPOLAR (SNR = 14.9 ± 5.3 versus 8.0 ± 3.1). CODE‐M1M2 cardiac ADCs were significantly lower than MONO (1.9 ± 0.6 versus 3.8 ± 0.3 x10−3 mm2/s) throughout the cardiac cycle and had higher SNR than MOCO at systole (9.1 ± 3.9 versus 7.0 ± 2.6) while reporting similar ADCs (1.5 ± 0.2 versus 1.4 ± 0.6 × 10−3 mm2/s).ConclusionsCODE significantly improved SNR for ADC mapping in the brain, liver and heart, and significantly improved DWI bulk motion robustness in the liver and heart. Magn Reson Med 77:717–729, 2017. © 2016 International Society for Magnetic Resonance in Medicine

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Magnetic Resonance in Medicine

Tập 77 Số 2

717-729

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