Higher Serum DHA and Slower Cognitive Decline in Patients with Alzheimer’s Disease: Two-Year Follow-Up

Nutrients - Tập 14 Số 6 - Trang 1159
Che‐Sheng Chu1,2,3,4, Chi‐Fa Hung5,6, Vinoth Kumar Ponnusamy7,8,9,10,11, Kuan-Chieh Chen12, Nai-Ching Chen13
1Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung City 813, Taiwan
2Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung City 813, Taiwan
3Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University (KMU), Kaohsiung City 807, Taiwan
4Non-Invasive Neuromodulation Consortium for Mental Disorders, Society of Psychophysiology, Taipei 114, Taiwan
5College of Humanities and Social Sciences, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
6Department of Psychiatric, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung City 833, Taiwan
7Department of Chemistry, National Sun Yat-sen University (NSYSU), Kaohsiung City, 804, Taiwan
8Department of Medical Research, Kaohsiung Medical University Hospital (KMUH), Kaohsiung City 807, Taiwan
9Department of Medicinal and Applied Chemistry, Kaohsiung Medical University (KMU), Kaohsiung City, 807, Taiwan
10Program of Aquatic Science and Technology, College of Hydrosphere Science, National Kaohsiung University of Science and Technology (NKUST), Kaohsiung City, 811, Taiwan
11Research Center for Environmental Medicine, Kaohsiung Medical University (KMU), Kaohsiung City 807, Taiwan
12College of Medicine, China Medical University, Taichung 406, Taiwan
13Department of Neurology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung City, 833, Taiwan

Tóm tắt

Omega-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have been associated with slower rates of cognitive decline. We investigated the association between omega-3 PUFAs and cognitive function in patients with Alzheimer’s disease (AD) receiving acetylcholinesterase inhibitors (AChEIs). This was a prospective cohort study using registered data. Patients with AD receiving AChEIs were recruited from 1 May 2016 to 30 April 2019 and were followed up for two years. Their daily diet record and blood concentration of omega-3 PUFAs were analyzed. Multiple linear and binary logistic regression was used to determine the factors associated with cognitive decline (continuous and dichotomized cognitive change). In the research, 129 patients with AD were identified with a mean age of 76.5 ± 6.6. Patients with AD with lower baseline omega-3 PUFAs levels were associated with a higher risk of cognitive decline than those with higher levels (odds ratio [OR] = 1.067, 95% confidence interval [CI]: 1.012, 1.125; p = 0.016) after adjustment. Patients with AD with a lower baseline DHA (OR = 1.131, 95% CI: 1.020, 1.254; p = 0.020), but not EPA, were associated with a higher risk of cognitive decline. We found that higher Mini-Nutritional Assessment scores (beta = −0.383, 95% CI = −0.182–−0.048, p = 0.001) and total fat (beta = −0.248, 95% CI = −0.067–−0.003, p = 0.031) were independently associated with slow cognitive decline in patients with AD receiving AChEIs. The baseline blood levels of omega-3 PUFAs were associated with cognitive decline in patients with AD receiving AChEIs. Future randomized controlled trials are needed to clarify whether this association is causal.

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Nutrients

Tập 14 Số 6

1159

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