Thyrotropin Suppressive Therapy in Thyroid Carcinoma: What Are the Targets?

Cooper, 2006, The American Thyroid Association Guidelines Taskforce. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer., Thyroid, 16, 109, 10.1089/thy.2006.16.109

Pacini, 2006, European Thyroid Cancer Taskforce. European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium., Eur J Endocrinol, 154, 787, 10.1530/eje.1.02158

McGriff, 2002, Effects of thyroid hormone suppression therapy on adverse clinical outcomes in thyroid cancer., Ann Med, 34, 554, 10.1080/078538902321117760

Eustatia-Rutten, 2006, Survival and death causes in differentiated thyroid carcinoma., J Clin Endocrinol Metab, 91, 313, 10.1210/jc.2005-1322

Jonklaas, 2006, Outcomes of patients with differentiated thyroid carcinoma following initial therapy., Thyroid, 16, 1229, 10.1089/thy.2006.16.1229

Kimura, 2001, Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models., Endocr Rev, 22, 631, 10.1210/edrv.22.5.0444

Belfiori, 2001, Graves’ disease, thyroid nodules and thyroid cancer., Clin Endocrinol (Oxf), 55, 711, 10.1046/j.1365-2265.2001.01415.x

Durante, 2007, BRAF mutations in papillary thyroid carcinomas inhibit genes involved in iodine metabolism., J Clin Endocrinol Metab, 92, 2840, 10.1210/jc.2006-2707

Potter, 1994, Western blot analysis of thyrotropin receptor expression in human thyroid tumours and correlation with TSH-binding., Biochem Biophys Res Commun, 205, 361, 10.1006/bbrc.1994.2673

Bruno, 2005, Modulation of thyroid-specific gene expression in normal and nodular human thyroid tissues from adults: an in vivo effect of thyrotropin., J Clin Endocrinol Metab, 90, 5692, 10.1210/jc.2005-0800

Fuhrer, 2003, Biological activity of activating thyroid-stimulating hormone receptor mutants depends on the cellular context., Endocrinology, 144, 4018, 10.1210/en.2003-0438

Kero, 2007, Thyrocyte-specific G(q)/G(11) deficiency impairs thyroid function and prevents goiter development., J Clin Invest, 117, 2399, 10.1172/JCI30380

Landriscina, 2005, Reverse transcriptase inhibitors down-regulate cell proliferation in vitro and in vivo and restore thyrotropin signaling and iodine uptake in human thyroid anaplastic carcinoma., J Clin Endocrinol Metab, 90, 5663, 10.1210/jc.2005-0367

Marians, 2002, Defining thyrotropin-dependent and -independent steps of thyroid hormone synthesis by using thyrotropin receptor-null mice., Proc Natl Acad Sci USA [Erratum (2005) 102:515], 99, 15776, 10.1073/pnas.242322099

Ying, 2006, Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone β receptor inhibits mitotic progression., J Clin Invest, 116, 2972, 10.1172/JCI28598

Kato, 2006, PPARγ insufficiency promotes follicular thyroid carcinogenesis via activation of the nuclear factor-κB signaling pathway., Oncogene, 25, 2736, 10.1038/sj.onc.1209299

Kim, 2007, Gelsolin: a novel thyroid hormone receptor-β interacting protein that modulates tumor progression in a mouse model of follicular thyroid cancer., Endocrinology, 148, 1306, 10.1210/en.2006-0923

Vlotides, 2007, Pituitary tumor-transforming gene: physiology and implications for tumorigenesis., Endocr Rev, 28, 165, 10.1210/er.2006-0042

Saez, 2006, Prognostic significance of human pituitary tumor-transforming gene immunohistochemical expression in differentiated thyroid cancer., J Clin Endocrinol Metab, 91, 1404, 10.1210/jc.2005-2532

Furuya, 2007, Novel functions of thyroid hormone receptor mutants: beyond nucleus-initiated transcription., Steroids, 72, 171, 10.1016/j.steroids.2006.11.005

Takano, 2006, Thyroxine to triiodothyronine hyperconversion thyrotoxicosis in patients with large metastases of follicular thyroid carcinoma., Thyroid, 16, 615, 10.1089/thy.2006.16.615

Brenta, 2007, Potential therapeutic applications of thyroid hormone analogs., Nat Clin Pract Endocrinol Metab, 3, 632, 10.1038/ncpendmet0590