Environmental predators as models for bacterial pathogenesis

Wiley - Tập 9 Số 3 - Trang 563-575 - 2007
Hubert Hilbi1, Stefan Weber2, Curdin Ragaz2, Yves Nyfeler2, Simon Urwyler2
1Institute of Microbiology, ETH Zürich, Wolfgang-Pauli Strasse 10, 8093 Zürich, Switzerland. [email protected]
2Institute of Microbiology, ETH Zürich, Wolfgang-Pauli-Strasse 10, 8093, Zürich, Switzerland.

Tóm tắt

SummaryEnvironmental bacteria are constantly threatened by bacterivorous predators such as free‐living protozoa and nematodes. In the course of their coevolution with environmental predators, some bacteria developed sophisticated defence mechanisms, including the secretion of toxins, or the capacity to avoid lysosomal killing and to replicate intracellularly within protozoa. To analyse the interactions with bacterial pathogens on a molecular, cellular or organismic level, protozoa and other non‐mammalian hosts are increasingly used. These include amoebae, as well as genetically tractable hosts, such as the social amoeba Dictyostelium discoideum, the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Using these hosts, the virulence mechanisms of opportunistic pathogenic bacteria such as Legionella, Mycobacterium, Pseudomonas or Vibrio were found to be not only relevant for the interactions of the bacteria with protozoa, nematodes and insect phagocytes, but also with mammalian hosts including humans. Thus, non‐mammalian model hosts provide valuable insight into the pathogenesis of environmental bacteria.

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Tài liệu tham khảo

10.1111/j.1462-2920.2005.00771.x

10.1128/AEM.62.6.2022-2028.1996

10.1099/mic.0.27563-0

10.1128/AEM.58.8.2420-2425.1992

10.1128/iai.61.8.3503-3510.1993

10.1128/AAC.39.12.2684

10.1111/j.1462-5822.2005.00607.x

10.1128/AEM.64.1.279-286.1998

Bozue J.A., 1996, Interaction of Legionella pneumophila with Acanthamoeba castellanii: uptake by coiling phagocytosis and inhibition of phagosome‐lysosome fusion, Infect Immun, 64, 668, 10.1128/iai.64.2.668-673.1996

10.1128/IAI.64.7.2449-2456.1996

Brieland J.K., 1997, The role of Legionella pneumophila‐infected Hartmannella vermiformis as an infectious particle in a murine model of Legionnaires' disease, Infect Immun, 65, 5330, 10.1128/iai.65.12.5330-5333.1997

10.1016/S0966-842X(98)01425-5

10.1016/j.mib.2005.12.009

10.1111/j.1462-5822.2006.00703.x

10.1038/ng1447

10.1126/science.1094226

10.1126/science.1099776

10.1073/pnas.89.11.5188

10.1128/IAI.62.8.3254-3261.1994

10.1128/IAI.65.9.3759-3767.1997

10.1128/IAI.67.9.4427-4434.1999

10.1128/JB.184.11.3027-3033.2002

10.1073/pnas.96.26.15202

10.1016/j.bbrc.2005.04.060

10.1128/IAI.71.6.3540-3550.2003

10.1080/08927010500044286

10.1371/journal.ppat.0020034

10.1038/nature03481

10.1099/mic.0.27111-0

10.1111/j.1462-5822.2005.00633.x

10.1016/0966-842X(96)10041-X

10.1128/CMR.15.3.506-526.2002

10.1128/JB.183.21.6207-6214.2001

10.1016/S0882-4010(03)00027-5

10.1046/j.1462-2920.2000.00076.x

10.1038/nrm1224

10.1016/j.mib.2003.12.009

10.1128/CMR.17.2.413-433.2004

10.1111/j.1574-6968.1998.tb13298.x

10.1046/j.1462-5822.2000.00044.x

10.1128/IAI.67.7.3662-3666.1999

10.1128/JB.181.16.4879-4889.1999

10.1128/JB.183.24.7126-7134.2001

10.1128/IAI.70.3.1604-1608.2002

10.1111/j.1462-5822.2006.00793.x

10.1046/j.1365-2958.2001.02645.x

10.1017/CBO9780511525315

10.1046/j.1365-2958.1998.00680.x

10.1128/AEM.70.11.6826-6833.2004

10.1111/j.1462-5822.2004.00472.x

10.1111/j.1462-5822.2005.00528.x

10.1016/S0378-1097(03)00050-8

10.1016/S0092-8674(00)80958-7

10.1128/AEM.72.4.2885-2895.2006

10.1016/j.tim.2005.05.009

10.1111/j.1462-2920.2004.00556.x

10.1128/AAC.44.7.1990-1994.2000

10.1128/IAI.73.10.6272-6282.2005

10.1046/j.1365-2958.2002.02842.x

10.1128/IAI.70.1.69-78.2002

10.1128/IAI.72.7.4040-4051.2004

10.1046/j.1462-5822.2003.00335.x

10.1128/AEM.71.1.20-28.2005

10.1111/j.1365-2958.2004.04129.x

10.1099/00221287-147-11-3121

10.1046/j.1462-5822.2003.00285.x

10.1046/j.1365-2958.2003.03826.x

10.1111/j.1600-0854.2005.00356.x

10.1126/science.1116006

10.1128/AEM.72.2.1613-1622.2006

10.1128/CMR.17.1.98-106.2004

10.1073/pnas.052704399

10.1073/pnas.0510322103

10.1111/j.1462-5822.2005.00666.x

10.1074/jbc.M312741200

10.1136/jcp.33.12.1179

10.1128/IAI.67.5.2117-2124.1999

10.1016/j.femsre.2004.07.001

10.1016/j.tim.2005.01.003

10.1078/1438-4221-00177

10.1016/S0966-842X(00)01852-7

10.1128/IAI.68.5.2939-2947.2000

10.1128/IAI.71.6.3578-3586.2003

10.1111/j.1462-5822.2005.00493.x

10.1128/AEM.63.5.2047-2053.1997

10.1128/AEM.64.6.2256-2261.1998

10.1128/IAI.66.4.1768-1775.1998

10.1146/annurev.micro.54.1.567

10.1073/pnas.96.2.715

10.1073/pnas.96.5.2408

10.1128/AEM.00070-06

10.1084/jem.186.4.537

10.1084/jem.188.3.505

10.1016/j.tim.2004.03.007

10.1007/s002849900170

10.1371/journal.ppat.0020046

10.1111/j.1462-2920.2005.00851.x

10.1128/IAI.63.12.4576-4583.1995

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Wiley

Tập 9 Số 3

563-575

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