The role of inhibitory processes in the formation of functional properties of neurons in vibrissal projection zone of the cat somatosensory cortex

Springer Science and Business Media LLC - Tập 76 - Trang 198-206 - 1989
A. S. Batuev1, A. A. Alexandrov1, N. A. Scheynikov1, V. N. Kcharazia1, Chan Chinh An1
1Department of Higher Nervous Activity, Leningrad State University, Leningrad, USSR

Tóm tắt

The role of intracortical inhibitory processes in the formation of neuronal receptive fields in the vibrissal projection zone of the somatosensory cortex was studied. Iontophoretic application of picrotoxin and bicuculline blocks the inhibition and causes the loss of directional sensitivity in neurons. Activation of inhibition by distant glutamate application gives opposite results — neurons become direction sensitive. A dependence was found between spatial location of activated cells and the pattern of changes of their detector properties. Inhibitory processes caused by natural afferent stimulation lead to similar changes in the functional properties of neurons.

Tài liệu tham khảo

Alexandrov AA, Batuev AS, Dutova EA (1983) Spatial organization of intracortical inhibitory mechanisms. Rep Acad Sci USSR 269: 494–496 (in Russian) Batuev AS, Alexandrov AA, Scheynikov NA (1981) Inhibition as a basis for neuronal plasticity. Adv Physiol Sci 36: 11–22 Batuev AS, Alexandrov AA, Scheynikov NA (1982) Picrotoxin action on the receptive fields of the cat sensorimotor cortex neurons. J Neurosci Res 7: 49–55 Biscoe TI, Curtis DR (1967) Strychnine and cortical inhibition. Nature 214: 914–915 Curtis DR, Felix D (1971) The effects of bicuculline upon synaptic inhibition in the cerebral and cerebellar corticies of the cat. Brain Res 34: 301–321 Dykes RW, Landry P, Metherate R, Hicks TP (1984) Functional role of GABA in cat primary somatosensory cortex: shaping receptive fields of cortical neurons. J Neurophysiol 52: 1066–1093 Gardner EP, Costanzo RM (1980) Temporal integration of multiple-point stimuli in primary somatosensory cortical receptive fields of alert monkeys. J Neurophysiol 43: 444–468 Hellweg FC, Schultz W, Creutzfeldt OD (1977) Extracellular and intracellular recordings from cat's cortical whisker projection area: thalamocortical response transformation. J Neurophysiol 40: 463–479 Ito M (1981) Some quantitative aspects of vibrissa-driven neuronal responses in cat neocortex. J Neurophysiol 46: 705–715 Ito M (1985) Processing of vibrissa sensory information within the rat neocortex. J Neurophysiol 54: 479–490 Mountcastle VB, Davies PW, Berman AL (1957) Response properties of neurons of cat's somatic sensory cortex to peripheral stimuli. J Neurophysiol 20: 374–407 Sillito AM (1975) The contribution of inhibitory mechanisms to the receptive fields properties of neurons in the striate cortex of the cat. J Physiol (Lond) 250: 305–329 Sillito AM (1977) Inhibitory processes underlying the directional specificity of simple, complex, and hypercomplex cells in the cat visual cortex. J Physiol (Lond) 251: 699–720 Sillito AM (1979) Inhibitory mechanisms influencing complex cell orientation selectivity and their modification of higher resting discharge level. J Physiol (Lond) 289: 33–53 Sillito AM (1984) Functional considerations of the operation of GABA-ergic inhibitory processes in the visual cortex. In: Jones EG, Peters A (eds) Cerebral cortex, Vol 2. Functional properties of cortical cells. Plenum Press, New York London, pp 91–117 Simons DJ (1985) Temporal and spatial integration in the rat SI vibrissa cortex. J Neurophysiol 54: 615–635 Szentágothai J (1975) The “module-concept” in the cerebral cortex architecture. Brain Res 95: 475–496 Tsumoto T, Eckart W, Creutzfeldt OD (1979) Modifications of orientation sensitivity of cat visual cortex neurons by removal of GABA-mediated inhibition. Exp Brain Res 34: 351–363