Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

Molecular Therapy - Tập 26 Số 7 - Trang 1855-1866 - 2018
Christopher C. Kloss1,2, Ji‐Hyun Lee1, Aaron Zhang1, Fang Chen1, J. Joseph Melenhorst1,3,4, Simon F. Lacey1, Marcela V. Maus1, Joseph A. Fraietta1,3,4, Yangbing Zhao1,3, Carl H. June1,3,4,2
1Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5156, USA
2Smilow Center for Translational Research, 3400 Civic Center Blvd., Philadelphia, PA 19104-5156, USA
3Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-5156, USA
4Parker Institute for Cancer at the University of Pennsylvania, Philadelphia, PA 19104-5156, USA

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