99mTc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceutical

European Journal of Nuclear Medicine - Tập 9 - Trang 511-516 - 1984
W. A. Volkert1, T. J. Hoffman1, R. M. Seger1, D. E. Troutner2, R. A. Holmes1
1Department of Radiology, University of Missouri and Harry S. Truman Memorial Veterans Hospital, Columbia, USA
2Department of Chemistry, University of Missour and Harry S. Truman Memorial Veterans Hospital, Columbia, USA

Tóm tắt

Propylene amine oxime (PnAO) forms a neutral lipid soluble complex with 99mTc. 99mTc-PnAO can be prepared by simple reduction of 99mTc-pertechnetate with stannous ion in the presence of excess PnAO in saline at or near neutral pH. This agent will passively penetrate biological membranes including the intact blood-brain barrier (BBB) as evidenced by the high brain uptake observed shortly after IV injection. The first-pass extraction efficiency in baboons was estimated to be 80% at normal blood flow. This agent or a derivatized form of 99mTc-PnAO may be useful in assessment of regional cerebral blood flow (rCBF) in humans.

Tài liệu tham khảo

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