2019 Alzheimer's disease facts and figures

Alzheimer's & Dementia - Tập 15 Số 3 - Trang 321-387 - 2019

Tóm tắt

Abstract

This article describes the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality and morbidity, use and costs of care, and the overall impact on caregivers and society. The Special Report examines the use of brief cognitive assessments by primary care physicians as a tool for improving early detection of dementia. An estimated 5.8 million Americans have Alzheimer's dementia. By mid‐century, the number of people living with Alzheimer's dementia in the United States may grow to 13.8 million, fueled in large part by the aging baby boom generation. In 2017, official death certificates recorded 121,404 deaths from AD, making AD the sixth leading cause of death in the United States and the fifth leading cause of death among Americans age ≥65 years. Between 2000 and 2017, deaths resulting from stroke, heart disease, and prostate cancer decreased, whereas reported deaths from AD increased 145%. In 2018, more than 16 million family members and other unpaid caregivers provided an estimated 18.5 billion hours of care to people with Alzheimer's or other dementias. This care is valued at nearly $234 billion, but its costs extend to family caregivers' increased risk for emotional distress and negative mental and physical health outcomes. Average per‐person Medicare payments for services to beneficiaries age ≥65 years with Alzheimer's or other dementias are more than three times as great as payments for beneficiaries without these conditions. Total payments in 2019 for health care, long‐term care and hospice services for people age ≥65 years with dementia are estimated to be $290 billion. Early detection of Alzheimer's offers numerous medical, emotional and financial benefits—benefits that accrue to affected individuals and their families as well as to society at large. Alzheimer's Association surveys regarding brief cognitive assessments for detection of dementia found that while a large majority of seniors and primary care physicians say the assessments are important, only half of seniors have received an assessment, and only 16 percent of seniors receive regular cognitive assessments. Many educational opportunities exist to facilitate increased use of brief cognitive assessments in the primary care setting.

Từ khóa


Tài liệu tham khảo

10.1016/S1474-4422(13)70044-9

10.1016/S1474-4422(12)70228-4

10.1093/brain/awp062

10.1056/NEJMoa1202753

10.1016/S1474-4422(18)30028-0

10.1097/NEN.0b013e318232a379

National Institutes of Health.National Institute on Aging.What happens to the Brain in Alzheimer's Disease? Available at:https://www.nia.nih.gov/health/what‐happens‐brainalzheimers‐diseaseAccessed September 14 2018

10.1016/0197-4580(91)90006-6

10.1016/j.jalz.2011.03.003

10.1016/j.jalz.2011.03.008

10.1016/j.jalz.2011.03.005

10.1016/j.jalz.2011.03.004

10.1212/01.wnl.0000219668.47116.e6

10.1093/jnen/62.11.1087

10.1016/j.cger.2013.07.003

10.1212/WNL.0b013e3181a2e864

10.1111/j.1600-0447.2008.01326.x

10.1212/WNL.0000000000004826

10.1159/000354370

10.1037/a0029857

10.1097/00002093-200210000-00001

10.1212/01.wnl.0000341271.90478.8e

10.1212/01.wnl.0000271090.28148.24

10.1002/ana.21706

10.1016/j.jns.2007.01.045

10.1016/j.jalz.2006.09.002

10.1007/s00401-017-1717-7

10.1016/j.jalz.2016.09.015

De Reuck J, 2018, Aging and cerebrovascular lesions in pure and in mixed neurodegenerative and vascular dementia brains: A neuropathological study, Folia Neuropathol, 56, 81, 10.5114/fn.2018.76610

10.1001/jama.2012.3556

National Institute on Aging.What are frontotemporal disorders? Available at:https://www.nia.nih.gov/health/what‐are‐frontotemporal‐disordersAccessed December 19 2018

10.1007/s00441-017-2700-2

Stojkovsa I, 2018, Molecular mechanisms of alpha‐synuclein and GBA1 in Parkinson's disease, Cell Tissue Res, 373, 51, 10.1007/s00441-017-2704-y

McKhann GM, 2012, Alzheimer's disease — Modernizing concept, biological diagnosis and therapy, 115, 10.1159/000335402

10.3233/JAD-2011-110458

10.1016/j.arr.2015.11.005

10.1017/S1041610213001385

10.1016/j.arr.2012.07.001

Fukushima RLM, 2016, Effects of cognitive stimulation on neuropsychiatric symptoms in elderly with Alzheimer's disease: A systematic review, Dement Neuropsychol, 10, 178, 10.1590/S1980-5764-2016DN1003003

10.7326/M17-1530

10.7326/M17-1531

10.7326/M17-1528

10.7326/0003-4819-145-10-200611210-00004

10.2165/0002512-200926020-00005

Grossberg GT, 2010, The art of sharing the diagnosis and management of Alzheimer's disease with patients and caregivers: Recommendations of an expert consensus panel, Prim Care Companion J Clin Psychiatry, 12

10.1177/0891988710383571

10.1097/GIM.0b013e31821d69b8

10.1016/S1474-4422(10)70112-5

2018 Published by the National Down Syndrome Society New York NY National Down Syndrome Society Aging and Down syndrome: A health and well‐being guidebook

10.1212/WNL.0b013e3181f0754f

10.1212/WNL.0b013e31828726f5

10.1212/WNL.43.8.1467

10.1001/jama.1997.03550160069041

10.1001/jama.287.3.329

10.1002/ana.410330306

10.1001/archneur.1991.00530150037014

10.1212/WNL.46.3.641

10.1007/s00401-011-0826-y

10.1111/jgs.15059

10.1001/archneur.60.2.185

10.1001/jama.279.10.751

10.1016/S0140-6736(13)60630-3

10.1101/cshperspect.a006312

10.1016/j.jalz.2014.06.015

10.1038/510026a

10.1159/000334607

10.1056/NEJM199802193380804

10.1097/EDE.0000000000000747

10.1017/S1041610214000167

10.1001/jama.2013.2973

10.1212/WNL.0000000000003871

10.3233/JAD-2012-120676

10.1016/j.neurobiolaging.2015.12.013

10.1016/j.jalz.2015.05.016

2015, Cognitive Aging: Progress in Understanding and Opportunity for Action

10.1016/j.tins.2013.07.001

10.1001/jama.2018.11499

10.1093/aje/kwm116

10.1001/archinternmed.2010.393

10.1186/1471-2458-14-643

10.1111/jgs.13794

10.1002/acn3.633

10.1002/ana.21557

10.1111/jdi.12087

10.1093/epirev/mxs012

10.1038/nrneurol.2011.2

10.1159/000330020

10.1056/NEJMoa1215740

Sajeev G, Diabetes. The AlzRisk Database. Alzheimer Research Forum

10.1016/j.jalz.2017.09.016

10.1002/oby.20037

10.1111/j.1467-789X.2010.00825.x

Gottesman RF, 2017, Association between midlife vascular risk factors and estimated brain amyloid deposition, JAMA, 17, 1443, 10.1001/jama.2017.3090

10.1093/eurheartj/ehy288

10.1161/HYPERTENSIONAHA.110.163055

10.1212/WNL.0b013e318227b227

10.1016/S0140-6736(17)31363-6

10.1001/jamaneurol.2017.1658

10.1159/000231980

10.3233/JAD-140954

10.1001/archneurol.2008.582

Corrada MM, 2017, Age of onset of hypertension and risk of dementia in the oldest‐old: The 90+ Study, Alzheimers Dement, 103, 10.1016/j.jalz.2016.09.007

10.1001/jama.2018.21442

MHarrington JWeuve JWJackson DBlacker.Physical Activity. The AlzRisk Database. Alzheimer Research Forum Available at:http://www.alzrisk.orgAccessed September 14 2018

Tan ZS, 2017, Physical activity, brain volume, and dementia risk: The Framingham Study, J Gerontol A Biol Sci Med Sci, 72, 789

10.1212/WNL.0000000000002582

Stephen R, 2017, Physical Activity and Alzheimer's Disease: A systematic review, J Gerontol A Biol Sci Med Sci, 72, 733

10.1186/1471-2458-14-510

10.1007/s10522-017-9708-6

10.1155/2017/9016924

Soni M, 2017, Physical activity pre‐ and post‐dementia: English Longitudinal Study of Ageing, Aging Ment Health, 17, 1

10.1212/01.wnl.0000278116.37320.52

10.3389/fnut.2016.00022

10.1097/EDE.0b013e3182944410

10.1016/j.jalz.2015.04.011

10.1016/j.jalz.2014.11.009

10.1016/j.jalz.2017.09.006

10.3233/JAD-179919

10.1111/j.1532-5415.2004.52058.x

10.1001/archneur.59.11.1737

10.1016/S1474-4422(12)70191-6

10.1002/gps.2043

10.1093/geronb/gbx143

10.1017/S1355617702813248

10.1016/j.jalz.2018.07.219

Grzywacz JG, 2016, Workplace exposures and cognitive function during adulthood: Evidence from National Survey of Midlife Development and the O*NET, J Occup Environ Med, 58, 535, 10.1097/JOM.0000000000000727

10.1212/WNL.0000000000002569

10.1186/1745-6673-9-23

10.1037/a0035724

10.1080/13803390600582420

Harris CD, 2013, Adult participation in aerobic and muscle strengthening physical activities — United States, 2011, Morb Mortal Wkly Rep, 62, 326

10.1001/jama.2015.10029

10.1016/j.annepidem.2011.05.006

10.1371/journal.pone.0027670

Steptoe A, 2005, Aging, Health, and Public Policy

10.1016/j.bbadis.2011.09.002

10.1093/aje/155.12.1081

10.1093/aje/kwj061

Karp A, 2005, Mental, physical and social components in leisure activities equally contribute to decrease dementia risk, Dement Geriatr Cogn Disord, 21, 65, 10.1159/000089919

10.3233/JAD-132225

10.1017/S1355617711000531

Yates LA, 2016, Cognitive leisure activities and future risk of cognitive impairment and dementia: Systematic review and meta‐analysis, Int Psychogeriatr, 9, 1

10.1001/jama.288.18.2271

10.1212/WNL.0b013e3181b04ae3

Sanjeev G, 2016, Late‐life cognitive activity and dementia, Epidemiology, 27, 732, 10.1097/EDE.0000000000000513

10.1212/01.WNL.0000036905.59156.A1

Centers for Disease Control and Prevention, 2017, Traumatic Brain Injury‐Related Emergency Department Visits, Hospitalizations, and Deaths — United States, 2007 and 2013, MMWR Surveill Summ, 66, 1

10.1212/WNL.55.8.1158

10.1016/S0140-6736(74)91639-0

Centers for Disease Control and Prevention.Traumatic Brain Injury & Concussion.Potential Effects Available at:https://www.cdc.gov/traumaticbraininjury/outcomes.htmlAccessed September 14 2018

10.1016/S2215-0366(18)30065-8

10.1001/jamaneurol.2018.0815

10.1001/jamaneurol.2017.2396

10.1111/bpa.12248

10.1007/s00401-015-1515-z

He W, 2016, International Population Reports, P95/16‐1, An Aging World: 2015

U.S. Census Bureau.National Population Projections: Downloadable Files Available at:https://www.census.gov/data/datasets/2014/demo/popproj/2014‐popproj.html2014Accessed December 18 2018

Administration on Aging.Administration for Community Living U.S. Department of Health and Human Services. A Profile of Older Americans Available at:https://www.acl.gov/sites/default/files/Aging%20and%20Disability%20in%20America/2016‐Profile.pdf2016Accessed December 18 2018

2006, Early‐Onset Dementia: A National Challenge, a Future Crisis

10.1159/000109998

10.1016/j.jalz.2010.11.006

10.7326/0003-4819-138-11-200306030-00015

10.1097/WAD.0b013e3181a6bebc

10.1212/WNL.0000000000001096

10.3233/JAD-2009-1099

10.1111/j.1532-5415.2006.00992.x

10.1097/WAD.0b013e3182351c04

10.1111/jgs.14164

Healthy People 2020. Dementias Including Alzheimer's Disease Available at:http://www.healthypeople.gov/2020/topics‐objectives/topic/dementias‐including‐alzheimers‐disease/national‐snapshotAccessed December 18 2018

Alzheimer's Association.Alzheimer's Disease Facts and Figures. Special report: Disclosing a diagnosis of Alzheimer's disease Available at:https://www.alzheimersanddementia.com/article/S1552‐5260(15)00058‐8/fulltext2015Accessed December 18 2018

10.1017/S1041610207006412

10.1016/j.jalz.2012.09.017

10.1016/j.jalz.2014.01.001

10.1016/j.jalz.2015.12.013

10.1016/j.jalz.2013.02.007

10.1212/WNL.0000000000002153

10.1016/j.jalz.2009.10.002

10.3233/JAD-150956

10.3233/JAD-160407

10.15585/mmwr.mm6727a1

10.1016/j.jalz.2018.07.216

10.2105/AJPH.2014.301935

10.1097/00002093-200110000-00002

10.1016/j.jalz.2013.10.005

10.1097/EDE.0000000000000199

10.2147/CLEP.S37929

10.1212/WNL.49.6.1498

10.1093/aje/153.2.132

10.1212/WNL.54.11.2072

10.1089/jwh.2012.3789

10.1002/ana.24135

10.1007/s11682-013-9272-x

10.1001/jamaneurol.2018.0821

10.1001/jamaneurol.2017.2188

10.1212/WNL.54.10.1949

10.1016/j.neurobiolaging.2010.10.007

10.1016/j.maturitas.2014.05.008

10.1016/j.jalz.2008.03.001

Manly JJ, 2004, Critical perspectives on racial and ethnic differentials in health in late life, 95

10.1016/S1047-2797(02)00437-4

10.1007/s11920-000-0040-4

10.1212/WNL.49.1.44

10.3233/JAD-150778

10.1016/j.jalz.2009.04.1234

10.1002/(SICI)1099-1166(199906)14:6<481::AID-GPS959>3.0.CO;2-5

10.1046/j.1532-5415.2003.51054.x

10.1016/j.jamda.2010.07.010

10.1016/j.jalz.2016.06.2360

10.1136/bmj.f7051

10.1046/j.1532-5415.2001.49096.x

10.1097/WAD.0b013e318211c6c9

Lines LM, 2014, Racial and ethnic disparities among individuals with Alzheimer's disease in the United States: A literature review

10.1007/s11065-008-9064-z

10.1177/0022146516645925

10.1111/j.1532-5415.2005.53569.x

10.1046/j.1532-5415.2001.49257.x

10.1016/j.jalz.2018.06.3063

10.1016/j.jalz.2015.12.007

10.1097/WAD.0000000000000189

10.1093/aje/kwr074

10.1093/geronb/gbx169

Freedman VA, 2018, Short‐term changes in the prevalence of probable dementia: An analysis of the 2011–2015 National Health and Aging Trends Study, J Gerontol B Psychol Sci Soc Sci, 73, S48, 10.1093/geronb/gbx144

10.1016/S0140-6736(13)61570-6

10.1016/j.jalz.2010.11.002

10.1001/jamainternmed.2016.6807

10.1017/S0033291713000299

10.3233/JAD-150708

10.1016/j.jalz.2009.01.026

10.1038/nrneurol.2017.63

10.1212/WNL.0b013e3182553be6

10.1212/WNL.0b013e318292a2f9

10.1056/NEJMoa1504327

10.1038/ncomms11398

10.1016/j.jalz.2017.02.010

10.1001/jamaneurol.2017.1964

10.1136/bmj.j2856

Sullivan KJ, 2018, Declining incident dementia rates across four population‐based birth cohorts, J Gerontol A Biol Sci Med Sci

Kommer TN, 2018, Time trend in persistent cognitive decline: Results from the longitudinal aging study Amsterdam, J Gerontol B Psychol Sci Soc Sci, 73, S57, 10.1093/geronb/gbx151

10.1111/j.1600-0447.2010.01587.x

10.1093/geronb/gbx135

10.1093/geronb/gbx155

10.1186/s13195-015-0118-1

10.1056/NEJMp1311405

10.1093/geronb/gbx167

Prince MJ, 2015, World Alzheimer Report 2015: The Global Impact of Dementia: An Analysis of Prevalence

Ortman JM, 2014, An Aging Nation: The Older Population in the United States, Current Population Reports, P25‐1140

Heron M, 2018, Deaths: Leading causes for 2016

U.S. Department of Health and Human Services Centers for Disease Control and Prevention National Center for Health Statistics.CDC WONDER online database: About Underlying Cause of Death 1999‐2017 Available at:http://wonder.cdc.gov/ucd‐icd10.htmlAccessed December 18 2018

World Health Organization, 2004, International Statistical Classification of Diseases and Related Health Problems

10.1093/ageing/19.5.341

10.1111/j.1468-1331.2008.02503.x

10.1111/j.1532-5415.2008.02056.x

10.3233/JAD-131622

Romero JP, 2014, Under reporting of dementia deaths on death certificates: A systematic review of population‐based cohort studies, J Alzheimers Dis, 41, 213, 10.3233/JAD-132765

10.1111/j.1532-5415.1999.tb03842.x

10.1212/WNL.0000000000000240

10.1016/j.jalz.2014.01.004

10.1097/WAD.0b013e31819fe7d1

Tejada‐Vera B, 2013, Mortality from Alzheimer's disease in the United States: Data for 2000 and 2010

10.15585/mmwr.mm6620a1

10.1001/archneur.62.5.779

10.1097/01.wad.0000189033.35579.2d

10.1001/archneur.59.11.1764

10.7326/0003-4819-140-7-200404060-00008

10.1212/01.wnl.0000334278.11022.42

10.1136/bmj.39433.616678.25

10.1017/S1041610211002924

10.1002/gps.3946

10.1111/j.1532-5415.2005.53118.x

U.S. Burden of Disease Collaborators, 2018, The state of U.S. health, 1990‐2016: Burden of diseases, injuries, and risk factors among U.S. states, JAMA, 319, 1444, 10.1001/jama.2018.0158

10.2190/FACK-QE61-Y2J8-5L68

10.1037/h0092707

Friedman EM, 2015, U.S. prevalence and predictors of informal caregiving for dementia, Health Aff, 34, 1637, 10.1377/hlthaff.2015.0510

BSpillman JWolff VAFreedman JDKasper.Informal Caregiving for Older Americans: An Analysis of the 2011 National Health and Aging Trends Study Available at:https://aspe.hhs.gov/report/informal‐caregiving‐older‐americans‐analysis‐2011‐national‐study‐caregivingAccessed December 18 2018

Walmart.2018 Annual Report Available at:https://s2.q4cdn.com/056532643/files/doc_financials/2018/annual/WMT‐2018_Annual‐Report.pdfAccessed December 17 2018

McDonald's Corporation Report 2017 Available at:https://corporate.mcdonalds.com/content/dam/gwscorp/investor‐relations‐content/annual‐reports/McDonald%27s%202017%20Annual%20Report.pdfAccessed December 17 2018

10.1111/jgs.15043

Official Data Foundation.CPI inflation calculator Available at:http://www.in2013dollars.com/2017‐dollars‐in‐2018?amount=139765Accessed December 17 2018

10.1080/14737167.2017.1313118

10.1377/hlthaff.2015.0536

Alzheimer's Association.Issues Brief: LGBT and Dementia Available at:https://www.alz.org/media/Documents/lgbtdementia‐issues‐brief.pdfAccessed September 19 2018

Kasper JD, 2014, Disability and Care Needs of Older Americans by Dementia Status: An Analysis of the 2011 National Health and Aging Trends Study

10.2105/AJPH.2018.304573

10.1159/000087448

10.1111/j.1532-5415.2010.03304.x

National Alliance for Caregiving in Partnership with the Alzheimer's Association.Dementia Caregiving in the U.S. Bethesda Md Available at:http://www.caregiving.org/wp‐content/uploads/2014/01/Dementia‐Caregiving‐in‐the‐US_February‐2017.pdfAccessed December 18 2018

Unpublished data from the 2015 and 2016 Behavioral Risk Factor Surveillance System survey analyzed by and provided to the Alzheimer's Association by the Alzheimer's Disease and Healthy Aging Program (AD+HP) Centers for Disease Control and Prevention (CDC)

10.1111/jgs.14910

National Poll on Healthy Aging.Dementia Caregivers: Juggling Delaying and Looking Forward Available at:http://www.healthyagingpoll.org/sites/default/files/2017‐10/NPHA_Caregivers‐Report‐PROOF_101817_v2.pdfAccessed December 18 2018

National Alliance for Caregiving and AARP.Caregiving in the U.S.: Unpublished data analyzed under contract for the Alzheimer's Association.2009

Alzheimer's Association.2014 Alzheimer's Disease Facts and Figures. Special Report: Women and Alzheimer's Disease Available at:https://www.alzheimersanddementia.com/article/S1552‐5260(14)00062‐4/fulltextAccessed December 18 2018

Sorensen Pinquart M, 2006, Gender differences in caregiver stressors, social resources, and health: An updated metaanalysis, J Gerontol B Psychol Sci Soc Sci, 61, P33, 10.1093/geronb/61.1.P33

Ma M, 2017, Alzheimer's disease and caregiving: A meta‐analytic review comparing the mental health of primary carers to controls, Aging Ment Health, 5, 1

National Alliance for Caregiving AARP.Caregiving in the U.S. Available at:http://www.caregiving.org/wpcontent/uploads/2015/05/2015_CaregivingintheUS_Final‐Report‐June‐4_WEB.pdf2015Accessed December 18 2018

10.3928/00989134-20060601-07

10.1093/geront/45.suppl_1.87

10.1001/jama.292.8.961

10.1016/j.jalz.2014.11.004

10.1016/j.jalz.2016.03.008

10.1093/geront/gnx093

10.1017/S1041610212000737

10.1016/j.comppsych.2016.04.017

10.1017/S1041610216000922

10.1073/pnas.93.7.3043

10.1001/jama.282.23.2215

10.1037/0033-2909.129.6.946

Liu W, 2009, Aging families and caregiving, 85

10.1093/geronb/58.2.P112

10.1016/S1474-4422(06)70599-3

Goren A, 2016, Impact of caring for persons with Alzheimer's disease or dementia on caregivers' health outcomes: Findings from a community based survey in Japan, BMC Geriatr, 16, 122, 10.1186/s12877-016-0298-y

Alzheimer's Association.2016 Alzheimer's Disease Facts and Figures. Special Report: The Personal Financial Impact of Alzheimer's Disease on Families Available at:https://www.alzheimersanddementia.com/article/S1552‐5260(16)00085‐6/fulltextAccessed October 25 2018

10.1159/000461577

10.1080/13607863.2012.692768

10.1093/geront/gnu118

10.1093/geront/gnu001

10.1093/geronb/gbv034

10.1177/1471301214564792

10.1016/j.ijnurstu.2017.10.008

10.1093/geront/35.6.771

10.1016/0895-4356(92)90189-T

10.1016/j.jagp.2012.10.001

10.1001/archpsyc.62.6.617

10.1016/j.jamda.2015.09.007

10.1111/ijs.12535

10.1111/nhs.12205

10.1097/JGP.0b013e318235b62f

Vitaliano PP, 2017, Objective and subjective cognitive problems among caregivers and matched non‐caregivers, Gerontologist, 57, 637

10.1093/geront/gnv148

10.1017/S104161021700237X

10.1111/jocn.12519

10.1016/j.ijpharm.2015.12.050

Polenick CA, 2018, Stressors and resources related to medication management: Associations with spousal caregivers' role overload, Gerontologist

10.1186/s12877-017-0638-6

Badana ANS, 2017, Racial differences in caregiving: Variation by relationship type and dementia care status, J Aging Health

10.1186/1741-7015-8-85

Mausbach BT, 2014, Why does placement of persons with Alzheimer's disease into long‐term care improve caregivers' well‐being? Examination of psychological mediators, Psychol Aging, 29, 776, 10.1037/a0037626

10.1017/S1478951512000831

10.1056/NEJMsa035373

10.1017/S1041610214000039

10.1080/15402002.2013.819470

Peng H‐L, 2012, Sleep disturbance in family caregivers of individuals with dementia: A review of the literature, Perspect Psychiatr Care, 49, 135, 10.1111/ppc.12005

10.1007/s11136-015-1100-x

10.1016/j.healthpol.2015.09.014

MetLife Mature Market Institute.The MetLife Study of Alzheimer's Disease: The Caregiving Experience.2006 Available at:http://docplayer.net/20982840‐The‐metlife‐study‐of‐alzheimer‐s‐disease‐the‐caregiving‐experience.htmlAccessed December 18 2018

10.1093/geront/gnu078

10.1016/j.ypmed.2006.04.009

10.3109/10253890.2011.596866

10.1037/a0025536

10.1159/000334219

10.1097/PSY.0b013e3182408c14

10.1037/a0027783

10.1080/08870446.2011.637559

10.1093/gerona/61.9.963

10.1097/00006842-199107000-00001

Kiecolt‐‐Glaser JK, 1995, Slowing of wound healing by psychological stress, Lancet, 346, 1194, 10.1016/S0140-6736(95)92899-5

10.1097/00006842-200205000-00006

10.1097/PSY.0000000000000497

10.1016/S0022-3999(98)00084-1

10.1016/j.jacc.2009.11.093

10.1016/j.neubiorev.2016.12.006

10.1007/s11606-008-0711-0

10.1016/j.jalz.2013.12.018

10.1093/geront/gnu177

10.1056/NEJMsa050196

10.1093/geronb/gbs084

AARP.Family Caregiving and Out‐of‐Pocket Costs: 2016 Report Available at:https://www.aarp.org/content/dam/aarp/research/surveys_statistics/ltc/2016/family‐caregiving‐costsfact‐sheet.doi.10.26419%252Fres.00138.002.pdfAccessed December 18 2018

10.1017/S1041610216001514

10.1016/B978-0-12-417046-9.00017-9

Maslow K, 2012, Translating Innovation to Impact: Evidence‐Based Interventions to Support People with Alzheimer's Disease and their Caregiver at Home and in the Community

Rosalynn Carter Institute for Caregiving.Caregiver Intervention Database Available at:http://www.rosalynncarter.org/caregiver_intervention_database/Accessed December 18 2018

Liew TM, 2018, Reappraising the efficacy and acceptability of multicomponent interventions for caregiver depression in dementia: The utility of network meta‐analysis, Gerontologist

Menne HL, 2014, Statewide implementation of “reducing disability in Alzheimer's disease”: Impact on family caregiver outcomes, J Gerontol Soc Work, 57, 626, 10.1080/01634372.2013.870276

10.1093/geront/gnr132

10.1093/geront/gnq057

10.1093/geront/gnp012

10.1377/hlthaff.2013.1334

10.1002/gps.4160

10.1080/01634372.2013.859201

10.1371/journal.pone.0089290

10.1177/0733464815591212

Primetica B, 2015, Evidence‐Based Program replication: Translational activities, experiences, and challenges, J Appl Gerontol, 34, 652, 10.1177/0733464813508888

10.1016/j.cct.2016.07.006

10.1093/geront/gnu112

Teri L, 2018, Translating an evidence‐based multicomponent intervention for older adults with dementia and caregivers, Gerontologist

10.1080/01634372.2017.1400486

10.1093/geront/gny001

Fauth EB, 2017, External validity of the New York University Caregiver Intervention: Key caregiver outcomes across multiple demonstration projects, J Appl Gerontol

10.1111/jgs.15283

Boots LM, 2015, A systematic review of internet‐based supportive interventions for caregivers of patients with dementia, Int J Geriatr Psychiatry, 29, 331, 10.1002/gps.4016

10.1016/j.jagp.2013.02.019

10.1093/geront/gnv123

10.1177/0733464817723088

10.2196/mhealth.9345

10.1093/geront/gny078

10.1186/s12877-017-0654-6

10.2196/jmir.9548

U.S. Department of Health and Human Services.National Research Summit on Care Services and Supports for Persons with Dementia and their Caregivers Available at:https://aspe.hhs.gov/national‐research‐summit‐care‐services‐and‐supports‐persons‐dementia‐and‐their‐caregiversAccessed November 13 2018

10.1016/j.cger.2014.04.003

10.1093/geront/gnu123

10.1016/B978-0-12-417046-9.00011-8

Zarit SH, 2017, Past is prologue: How to advance caregiver interventions, Aging Ment Health, 16, 1

Zarit SH, 2009, Aging families and caregiving, 131

10.1080/13607863.2012.717252

10.1017/S1041610215001817

10.1093/geront/gnv150

10.1111/jgs.15541

Whitlatch CJ, 2018, Meeting the informational, educational, and psychosocial support needs of persons living with dementia and their family caregivers, Gerontologist, 58, S58

10.1093/geront/gnu045

10.1177/1533317512439794

10.1080/01634372.2013.850584

10.1080/01634372.2013.854856

10.1177/1533317510370957

10.1111/jrh.12195

10.1111/jgs.14204

10.1007/s13142-017-0505-1

Meyer OL, 2017, Acculturation level and caregiver outcomes from a randomized intervention trial to enhance caregivers' health: Evidence from REACH II, Aging Ment Health, 24, 1

Fields NL, 2016, The Senior Companion Program Plus: A culturally tailored psychoeducational training program (innovative practice), Dementia (London)

10.1111/jgs.15450

10.1177/1533317517749465

10.1177/0733464816672047

Khatutsky G, 2011, Understanding direct care workers: A snapshot of two of America's most important jobs: Certified nursing assistants and home health aides

Stone R, 2012, Universal Coverage of Long‐Term Care in the United States: Can We Get There from Here?, 155

Jones AL, 2009, The National Nursing Home Survey: 2004 Overview, Vital Health Stat, 13, 1

Kramer NA, 2000, Professional psychology in long‐term care, 227

10.1080/13607860601086405

10.1002/(SICI)1099-1166(199903)14:3<197::AID-GPS972>3.0.CO;2-Q

Institute of Medicine, 2008, Retooling for an Aging America: Building the Health Care Workforce

10.1377/hlthaff.2013.1232

American Health Care Association.Staffing Survey Report. 2011

10.1016/B978-0-12-417046-9.00006-4

Elvish R, 2018, ‘Getting to know me’: The second phase roll‐out of a staff training programme for supporting people with dementia in general hospitals, Dementia (London), 17, 96, 10.1177/1471301216634926

10.1016/j.arr.2012.06.005

Bray J, 2015, Enabling hospital staff to care for people with dementia, Nurs Older People, 27, 29, 10.7748/nop.27.10.29.s21

10.3928/00220124-20140825-20

10.1016/j.ijnurstu.2015.09.009

Eldercare Workforce Alliance, 2012, Geriatrics Workforce Shortage: A Looming Crisis for our Families

The American Geriatrics Society.Current Geriatrician Shortfall Available at:https://www.americangeriatrics.org/sites/default/files/inline‐files/Current‐Geriatrician‐Shortfall_0.pdfAccessed December 18 2018

The American Geriatrics Society.Projected Future Need for Geriatricians Available at:https://www.americangeriatrics.org/sites/default/files/inline‐files/Projected‐Future‐Need‐for‐Geriatricians_1.pdfAccessed December 18 2018

American Association of Nurse Practitioners.NP Fact Sheet Available at:https://www.aanp.org/all‐about‐nps/np‐factsheetAccessed December 18 2018

10.5888/pcd13.160233

10.1001/jama.2014.304

10.3928/19404921-20160531-02

10.1016/j.jalz.2016.01.005

Cross AJ, 2018, The psychosocial impact of caregiving in dementia and quality of life: A systematic review and meta‐synthesis of qualitative research, Psychol Health, 27, 1

10.1017/S1041610215002318

10.1080/13607863.2015.1119802

10.1080/02701960.2013.801342

10.3109/13561820.2013.817384

10.2174/1567205011666140618100727

10.1177/0733464816657472

10.1177/0733464815589986

10.1377/hlthaff.2013.1294

10.1377/hlthaff.2013.1260

10.1377/hlthaff.2013.1221

10.1016/j.cger.2014.05.001

10.1111/jgs.12562

10.1001/jamapsychiatry.2017.2124

10.1111/jgs.14808

10.1007/s00391-017-1220-8

10.5014/ajot.2013.676004

10.1111/jgs.13447

National Academies of Sciences, 2016, Engineering, and Medicine. Families Caring for an Aging America

Gaugler JE, 2015, Family Caregiving in the New Normal

The Lewin Group.Process Evaluation of the Older Americans Act Title IIIE‐National Family Caregiver Support Program: Final Report Available at:https://acl.gov/sites/default/files/programs/2017‐02/NFCSP_Final_Report‐update.pdf2016Accessed December 18 2018

10.1056/NEJMsa1204629

Unpublished tabulations based on data from the Medicare Current Beneficiary Survey for 2011.Prepared under contract by Avalere Health March 2016

10.1111/j.1475-6773.2011.01365.x

10.1212/01.WNL.0000036904.73393.E4

10.1016/j.whi.2015.06.001

10.1097/MLR.0000000000000869

10.7326/M15-0381

Unpublished tabulations based on data from the National 5% Sample Medicare Fee‐for‐Service Beneficiaries for 2014.Prepared under contract by Avalere Health January 2016

Bynum JPW, 2016, Our Parents, Ourselves: Health Care for an Aging Population. A Report of the Dartmouth Atlas Project

10.1111/j.1532-5415.2010.02924.x

10.3233/JAD-150228

10.1001/jamainternmed.2017.5034

U.S. Centers for Medicare & Medicaid Services.State Level Chronic Conditions Table: Prevalence Medicare Utilization and Spending Available at:https://www.cms.gov/Research‐Statistics‐Data‐and‐Systems/Statistics‐Trends‐and‐Reports/Chronic‐Conditions/CC_Main.html2015Accessed December 18 2018

Medicare. Glossary.Medicare: The Official U.S. Government Site for Medicare Available at:http://www.medicare.gov/HomeHealthCompare/Resources/Glossary.htmlAccessed December 18 2018

10.1016/j.jalz.2015.01.007

10.1177/1533317513488911

10.1111/jgs.14227

10.1007/s40258-013-0038-9

10.1093/gerona/glv124

10.1186/s12877-016-0303-5

Genworth.2017 Cost of Care: Annual Costs Available at:https://www.genworth.com/dam/Americas/US/PDFs/Consumer/corporate/cost‐of‐care/179703_2017CofC_Annual_092717.pdfAccessed December 18 2018

Genworth.Cost of Care Survey 2018: Median Cost Data Tables Available at:https://pro.genworth.com/riiproweb/productinfo/pdf/282102.pdfAccessed December 18 2018

Penn Lendon J, 2018, Variation in adult day services center participant characteristics, by center ownership: United States, 2016, NCHS Data Brief

Rome V, 2015, Variation in operating characteristics of adult day services centers by center ownership: United States, 2014, NCHS Data Brief, 1

Caffrey C, 2018, Variation in residential care community resident characteristics, by size of community: United States, 2016, NCHS Data Brief, 1

Caffrey C, 2015, Variation in operating characteristics of residential care communities by size of community: United States, 2014, NCHS Data Brief

Harris‐Kojetin L, 2016, Long‐term care providers and services users in the United States: Data from the National Study of Long‐Term Care Providers, 2013–2014, Vital Health Stat, 3, x–xii

U.S. Centers for Medicare & Medicaid Services.Nursing Home Data Compendium 2015 Edition Available at:https://www.cms.gov/Medicare/Provider‐Enrollment‐and‐Certification/CertificationandComplianc/Downloads/nursinghomedatacompendium_508‐2015.pdfAccessed December 18 2018

American Health Care Association.LTC Stats: Nursing Facility Operational Characteristics Report.Table 5: Nursing Facility Beds in Dedicated Special Care Units;2014

10.1001/jama.2012.207624

Eiken S, 2018, Medicaid Expenditures for Long‐Term Services and Supports in FY 2016. IAP Medicaid Innovation Accelerator Program

Bynum J, 2009, Unpublished; provided under contract with the Alzheimer's Association

10.1016/j.jval.2017.04.004

Nickel F, 2018, Health economic evaluations of non‐pharmacological interventions for persons with dementia and their informal caregivers: A systematic review, BMC Geriatr, 18, 69, 10.1186/s12877-018-0751-1

10.1111/j.1532-5415.2012.03905.x

10.1056/NEJMsa1100347

10.1089/jpm.2008.0168

Jacobson G, 2017, Income and Assets of Medicare Beneficiaries, 2016‐2035

U.S. Department of Health and Human Services.What is Long‐Term Care Insurance? Available at:http://longtermcare.gov/costs‐how‐to‐pay/what‐is‐long‐term‐care‐insurance/Accessed December 18 2018

U.S. Centers for Medicare & Medicaid Services.Your Medicare Coverage. Long‐Term Care Available at:https://www.medicare.gov/coverage/long‐term‐care.htmlAccessed December 18 2018

National Association of Insurance Commissioners and the Center for Insurance Policy and Research, 2016, The State of Long‐Term Care Insurance: The Market, Challenges and Future Innovations

Reaves EL, 2015, Medicaid and Long‐Term Services and Supports: A Primer

10.1016/j.jamda.2017.10.003

10.1056/NEJMsa1408705

U.S. Centers for Medicare & Medicaid Services.Medicare Provider Utilization and Payment Data: Hospice Providers Available at:https://www.cms.gov/Research‐Statistics‐Data‐and‐Systems/Statistics‐Trends‐and‐Reports/Medicare‐Provider‐Charge‐Data/Hospice.htmlAccessed November 11 2018

U.S. Centers for Medicare & Medicaid Services. Hospices Available at:https://www.cms.gov/Medicare/Provider‐Enrollment‐and‐Certification/CertificationandComplianc/Hospices.htmlAccessed November 11 2018

U.S. Centers for Medicare & Medicaid Services Medicare Learning Network.Update to Hospice Payment Rates Hospice Cap Hospice Wage Index and Hospice Price for FY 2018. MLN Matters MM10131 Available at:https://www.cms.gov/Outreach‐and‐Education/Medicare‐Learning‐Network‐MLN/MLNMattersArticles/downloads/MM10131.pdfAccessed November 11 2018

10.1089/jpm.2017.0485

10.1089/jpm.2011.0210

Miller SC, 2001, Hospice enrollment and hospitalization of dying nursing home patients, Am J Med, 11, 38, 10.1016/S0002-9343(01)00747-1

10.1111/j.1532-5415.2010.03185.x

10.1046/j.1532-5415.2002.50118.x

10.1016/j.jpainsymman.2007.06.011

10.1377/hlthaff.2013.1248

10.1001/jama.2016.9374

Gilligan AM, 2013, Health disparities in cost of care in patients with Alzheimer's disease: An analysis across 4 state Medicaid populations, Am J Alzheimers Dis Other Demen, 28, 84, 10.1177/1533317512467679

10.1016/j.jalz.2017.08.010

10.1007/s11606-014-2916-8

10.1161/CIRCHEARTFAILURE.114.001438

10.1016/j.jalz.2012.11.002

10.1377/hlthaff.2013.1179

Amjad H, 2016, Continuity of care and health care utilization in older adults, JAMA Intern Med, 176, 1371, 10.1001/jamainternmed.2016.3553

Alzheimer's Association.Changing the Trajectory of Alzheimer's Disease: How a Treatment by 2025 Saves Lives and Dollars Available at:https://www.alz.org/help‐support/resources/publications/trajectory_reportAccessed December 18 2018

10.1515/fhep-2014-0013

10.1016/j.jalz.2018.02.001

10.7249/RR2272

10.3233/JAD-150692

Alzheimer's Association.Why Get Checked? Available at:https://www.alz.org/alzheimers‐dementia/diagnosis/why‐get‐checkedAccessed January 3 2019

Starfield B, 1998, Primary Care: Balancing Health Needs, Services, and Technology, 10.1093/oso/9780195125429.001.0001

10.1377/hlthaff.2010.0026

Robert Graham Center.The State of Primary Care in the United States: A Chartbook of Facts and Statistics Available at:https://www.graham‐center.org/content/dam/rgc/documents/publications‐reports/reports/PrimaryCareChartbook.pdfAccessed January 22 2019

Centers for Disease Control and Prevention.National Ambulatory Medical Care Survey: 2015 State and National Summary Tables Available at:https://www.cdc.gov/nchs/data/ahcd/namcs_summary/2015_namcs_web_tables.pdfAccessed January 22 2019

Centers for Disease Control and Prevention National Center for Health Statistics.Tables of Summary Health Statistics 2017 National Health Interview Survey Available at:https://www.cdc.gov/nchs/nhis/shs/tables.htmAccessed January 22 2019

Henry J. Kaiser Family Foundation.Percent of Women who Report Having No Personal Doctor/Health Care Provider by Race/Ethnicity Available at:https://www.kff.org/disparities‐policy/state‐indicator/no‐personal‐doctor/?currentTimeframe=0&sortModel=%7B%22colId%22:%22Location%22 %22sort%22:%22asc%22%7DAccessed January 22 2019

Henry J. Kaiser Family Foundation.Percent of Men who Report Having No Personal Doctor/Health Care Provider by Race/Ethnicity Available at:https://www.kff.org/disparities‐policy/state‐indicator/percent‐of‐men‐who‐report‐having‐no‐personal‐doctorhealth‐care‐provider‐by‐raceethnicity/Accessed January 22 2019

10.1093/gerona/glp188

10.3399/bjgp16X686101

10.1111/j.1365-2753.2009.01235.x

Urban Institute Health Policy Center Health Reform Monitoring Survey.Do Patients Trust Their Providers? Available at:http://hrms.urban.org/briefs/do‐patients‐trust‐their‐providers.html2017Accessed January 22 2019

Urban Institute Health Policy Center Health Reform Monitoring Survey.Patients Feel Comfortable Talking to Their Providers about Sensitive Issues But Providers Don't Often Ask Available at:http://hrms.urban.org/briefs/patients‐comfortable‐talking‐providers‐sensitive‐issues.html2017Accessed January 22 2019

American Society on Aging.MetLife Foundation Harris Interactive Inc. Attitudes and Awareness of Brain Health Poll Available at:http://www.paulnussbaum.com/metlifedoc.pdf2006Accessed January 22 2019

John A. Hartford Foundation.How Does It Feel?: The Older Adult Health Care Experience Available at:https://www.johnahartford.org/events/view/john‐a.‐hartford‐foundation‐public‐poll‐how‐does‐it‐feel‐the‐older‐adult‐he2012Accessed January 22 2019

U.S. Centers for Medicare & Medicaid Services Enterprise Portal.Beneficiaries Utilizing Free Preventive Services by State Available at:https://downloads.cms.gov/files/Beneficiaries%20Utilizing%20Free%20Preventive%20Services%20by%20State%20YTD%202016.pdf2016Accessed January 22 2019

U.S. Centers for Medicare & Medicaid Services Enterprise Portal.Beneficiaries Utilizing Free Preventive Services by State Available at:https://downloads.cms.gov/files/Beneficiaries%20Utilizing%20Free%20Preventive%20Services%20by%20State%20YTD%202015.pdf2015Accessed January 22 2019

10.1001/jama.2017.4342

U.S. Centers for Medicare & Medicaid Services.Medicare Learning Network.Annual Wellness Visit Available at:https://www.cms.gov/Outreach‐and‐Education/Medicare‐Learning‐Network‐MLN/MLNProducts/Downloads/AWV_Chart_ICN905706.pdf2018Accessed January 22 2019

National Institute on Aging.Alzheimer's and Dementia Resources for Professionals. Available at:https://www.nia.nih.gov/health/alzheimers‐dementia‐resources‐for‐professionals. Accessed January 31 2019

Alzheimer's Association.Cognitive Assessment Toolkit. Available at:https://www.alz.org/media/Documents/cognitive‐assessment‐toolkit.pdf. Accessed January 22 2019

Gerontological Society of America.KAER Toolkit: 4‐Step Process to Detecting Cognitive Impairment and Earlier Diagnosis of Dementia Available at:https://www.geron.org/programs‐services/alliances‐and‐multi‐stakeholder‐collaborations/cognitive‐impairment‐detection‐and‐earlier‐diagnosis2015Accessed January 22 2019

American Academy of Family Physicians.Cognitive Care Kit. Available at:https://www.aafp.org/patient‐care/public‐health/cognitive‐care.html. Accessed January 22 2018

Act on Alzheimer's®.Provider Practice Tools. Available at:http://actonalz.org/provider‐practice‐tools. Accessed January 31 2019

10.1177/0733464811401354

Creavin ST, 2016, Mini‐Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations, Cochrane Database Syst Rev, 1

Ranson JM, 2018, Predictors of dementia misclassification when using brief cognitive assessments, Neurol Clin Pract

Warren‐Findlow J, 2010, Primary care providers' sources and preferences for cognitive health information in the United States, Health Promot Int, 25, 464, 10.1093/heapro/daq043

10.1097/WAD.0000000000000039

10.2217/nmt.15.43

10.2217/nmt-2016-0004

10.3122/jabfm.2010.04.090225

10.2105/AJPH.93.4.635

Yarnall KS, 2009, Family physicians as team leaders: “Time” to share the care, Prev Chronic Dis, 6, A59

10.1002/gps.1524

10.1016/j.dadm.2015.01.002

10.1111/j.1525-1497.2005.0126.x

10.1016/j.jalz.2012.09.011

Alzheimer's Association and the Centers for Disease Control and Prevention.Healthy Brain Initiative: State and Local Public Health Partnerships to Address Dementia: The 2018‐2023 Road Map Available at:https://www.cdc.gov/aging/pdf/2018‐2023‐Road‐Map‐508.pdfAccessed January 21 2019

10.1016/j.dadm.2015.06.009

10.1186/1471-2318-13-134

Pond D, 2018, Effectiveness of a peer‐mediated educational intervention in improving general practitioner diagnostic assessment and management of dementia: A cluster randomised controlled trial, BMJ Open, 8, e021125, 10.1136/bmjopen-2017-021125

10.1016/j.jalz.2017.08.003

10.1016/j.jalz.2018.07.220

10.1001/archneur.60.8.1119

10.2105/AJPH.88.9.1337

National Alliance for Caregiving and AARP.Caregiving in the U.S. November2009 Available at:https://www.caregiving.org/pdf/research/FINALRegularExSum50plus.pdfAccessed January 22 2019

Amo PS, 1999, The economic value of informal caregiving, Health Aff, 18, 182, 10.1377/hlthaff.18.2.182

U.S. Department of Labor Bureau of Labor Statistics.Employment Hours and Earnings from the Current Employment Statistics Survey.Series 10‐CEU 6562160008 Home Health Care Services (NAICS code 6216) Average Hourly Earnings July2018 Available at:www.bls.gov/ces/data.htmAccessed January 3 2019

Albert SM, 2010, The MetLife Study of working caregivers and employer health care costs

U.S. Centers for Medicare & Medicaid Services.Health Expenditures by State of Residence 1991‐2014 Available at:https://www.cms.gov/Research‐Statistics‐Data‐and‐Systems/Statistics‐Trends‐and‐Reports/NationalHealthExpendData/NationalHealthAccountsStateHealthAccountsResidence.htmlAccessed December 18 2018

Shriver M, 2010, The Shriver Report: A Woman's Nation Takes on Alzheimer's