2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups

Annals of the Rheumatic Diseases - Tập 76 Số 12 - Trang 1955-1964 - 2017
Ingrid E. Lundberg1, Anna Tjärnlund2, Matteo Bottai3, Victoria P. Werth4, Clarissa Pilkington5, Marianne de Visser6, Lars Alfredsson3, Anthony A. Amato7, Richard J. Barohn8, Matthew H. Liang9, Jasvinder A. Singh10,11, Rohit Aggarwal12, Snjólaug Arnardottir13, Hector Chinoy14, Robert G. Cooper15, Katalin Dankó16, Mazen M. Dimachkie8, Brian M. Feldman17, Ignacio García‐De La Torre18, Patrick Gordon19, Taichi Hayashi20, James D. Katz21, Hitoshi Kohsaka22, Peter A. Lachenbruch23, Bianca Lang24, Yuhui Li25, Chester V. Oddis12, Marzena Olesińska26, Ann M. Reed27, Lidia Rutkowska‐Sak28, Helga Sanner29, Albert Selva-O’Callaghan30, Yeong Wook Song31, Jiří Vencovský32, Steven R. Ytterberg33, Frederick Miller34, Lisa G. Rider34
1Rheumatology Unit, D2:01, Karolinska University Hospital, Solna, Stockholm S-171 76, Sweden
2Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
3Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
4Department of Dermatology, Philadelphia VAMC and Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA
5Department of Rheumatology, Great Ormond Street Hospital for Children NHS Trust, London, UK
6Department of Neurology, Academic Medical Centre, Amsterdam, The Netherlands
7Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
8Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA
9Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, and Section of Rheumatology, Boston VA Healthcare, Boston, Massachusetts, USA
10Mayo Clinic College of Medicine, Rochester, Minnesota, USA
11University of Alabama and Birmingham VA Medical Center, Birmingham, USA
12Division of Rheumatology and Clinical Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
13Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
14National Institute of Health Research Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, University of Manchester, Manchester, UK
15MRC/ARUK Institute of Ageing and Chronic Disease, Faculty of Health & Life Sciences, University of Liverpool, Liverpool, UK
16Division of Immunology, 3rd Department of Internal Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
17Division of Rheumatology, Department of Pediatrics, University of Toronto and The Hospital for Sick Children, Toronto, Canada
18Department of Immunology and Rheumatology, Hospital General de Occidente, Secretaría de Salud, and University of Guadalajara, Guadalajara, Jalisco, Mexico
19Department of Rheumatology, King’s College Hospital NHS Foundation Trust, London, UK
20Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
21National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA
22Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
23Department of Public Health, Oregon State University, Corvallis, Oregon, USA
24Division of Rheumatology, Department of Pediatrics, IWK Health Centre and Dalhousie University, Halifax, Canada
25Department of Rheumatology and Immunology, People’s Hospital of Beijing University, Beijing, China
26Connective Tissue Diseases Department, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland
27Department of Pediatrics, Duke University, Durham, North Carolina, USA
28Paediatric Clinic of Rheumatology, Institute of Rheumatology, Warsaw, Poland
29Section of Rheumatology, Oslo University Hospital–Rikshospitalet, Oslo, Norway
30Vall d’Hebron General Hospital, Barcelona, Spain
31Department of Internal Medicine, Medical Research Center, Clinical Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
32Department of Rheumatology, Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
33Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, New York, USA
34US Department of Health and Human Services, Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland, USA

Tóm tắt

ObjectiveTo develop and validate new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIM) and their major subgroups.MethodsCandidate variables were assembled from published criteria and expert opinion using consensus methodology. Data were collected from 47 rheumatology, dermatology, neurology and paediatric clinics worldwide. Several statistical methods were used to derive the classification criteria.ResultsBased on data from 976 IIM patients (74% adults; 26% children) and 624 non-IIM patients with mimicking conditions (82% adults; 18% children), new criteria were derived. Each item is assigned a weighted score. The total score corresponds to a probability of having IIM. Subclassification is performed using a classification tree. A probability cut-off of 55%, corresponding to a score of 5.5 (6.7 with muscle biopsy) ‘probable IIM’, had best sensitivity/specificity (87%/82% without biopsies, 93%/88% with biopsies) and is recommended as a minimum to classify a patient as having IIM. A probability of ≥90%, corresponding to a score of ≥7.5 (≥8.7 with muscle biopsy), corresponds to ‘definite IIM’. A probability of <50%, corresponding to a score of <5.3 (<6.5 with muscle biopsy), rules out IIM, leaving a probability of ≥50 to <55% as ‘possible IIM’.ConclusionsThe European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for IIM have been endorsed by international rheumatology, dermatology, neurology and paediatric groups. They employ easily accessible and operationally defined elements, and have been partially validated. They allow classification of ‘definite’, ‘probable’ and ‘possible’ IIM, in addition to the major subgroups of IIM, including juvenile IIM. They generally perform better than existing criteria.

Từ khóa


Tài liệu tham khảo

Plotz, 1995, NIH conference. Myositis: immunologic contributions to understanding cause, pathogenesis, and therapy, Ann Intern Med, 122, 715, 10.7326/0003-4819-122-9-199505010-00010

Dalakas, 2015, Inflammatory muscle diseases, N Engl J Med Overseas Ed, 372, 1734, 10.1056/NEJMra1402225

Rider, 2004, International consensus on preliminary definitions of improvement in adult and juvenile myositis, Arthritis Rheum, 50, 2281, 10.1002/art.20349

Oddis, 2005, International consensus guidelines for trials of therapies in the idiopathic inflammatory myopathies, Arthritis Rheum, 52, 2607, 10.1002/art.21291

Medsger, 1970, The epidemiology of polymyositis, Am J Med, 48, 715, 10.1016/S0002-9343(70)80006-7

DeVere, 1975, Polymyositis: its presentation, morbidity and mortality, Brain, 98, 637, 10.1093/brain/98.4.637

Bohan, 1975, Polymyositis and dermatomyositis (first of two parts), N Engl J Med, 292, 344, 10.1056/NEJM197502132920706

Bohan, 1975, Polymyositis and dermatomyositis (second of two parts), N Engl J Med, 292, 403, 10.1056/NEJM197502202920807

Griggs, 1995, Inclusion body myositis and myopathies, Ann Neurol, 38, 705, 10.1002/ana.410380504

Tanimoto, 1995, Classification criteria for polymyositis and dermatomyositis, J Rheumatol, 22, 668

Targoff, 1997, Classification criteria for the idiopathic inflammatory myopathies, Curr Opin Rheumatol, 9, 527, 10.1097/00002281-199711000-00008

Mastaglia, 2002, Idiopathic inflammatory myopathies: epidemiology, classification, and diagnostic criteria, Rheum Dis Clin North Am, 28, 723, 10.1016/S0889-857X(02)00021-2

van der Meulen, 2003, Polymyositis: an overdiagnosed entity, Neurology, 61, 316, 10.1212/WNL.61.3.316

Dalakas, 2003, Polymyositis and dermatomyositis, Lancet, 362, 971, 10.1016/S0140-6736(03)14368-1

Hoogendijk, 2004, 119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10–12 October 2003, Naarden, The Netherlands, Neuromuscul Disord, 14, 337, 10.1016/j.nmd.2004.02.006

Troyanov, 2005, Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies: analysis of 100 French Canadian patients, Medicine, 84, 231, 10.1097/01.md.0000173991.74008.b0

Miller, 2004, Polymyositis: an overdiagnosed entity, Neurology, 63, 402, 10.1212/WNL.63.2.402

Bradley, 2004, Polymyositis: an overdiagnosed entity, Neurology, 63, 402, 10.1212/WNL.63.2.402

Hengstman, 2004, Polymyositis: an overdiagnosed entity, Neurology, 63, 402, 10.1212/WNL.63.2.402

Engel, 1986, Mononuclear cells in myopathies: quantitation of functionally distinct subsets, recognition of antigen-specific cell-mediated cytotoxicity in some diseases, and implications for the pathogenesis of the different inflammatory myopathies, Hum Pathol, 17, 704, 10.1016/S0046-8177(86)80180-0

Betteridge, 2016, Myositis-specific autoantibodies: an important tool to support diagnosis of myositis, J Intern Med, 280, 8, 10.1111/joim.12451

Rider, 2016, The juvenile idiopathic inflammatory myopathies: pathogenesis, clinical and autoantibody phenotypes, and outcomes, J Intern Med, 280, 24, 10.1111/joim.12444

Love, 1991, A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups, Medicine, 70, 360, 10.1097/00005792-199111000-00002

Singh, 2006, Development of classification and response criteria for rheumatic diseases, Arthritis Rheum, 55, 348, 10.1002/art.22003

Dougados, 2007, Classification criteria for rheumatic diseases: why and how?, Arthritis Rheum, 57, 1112, 10.1002/art.23015

Van de, 1974, The effectiveness of nominal, delphi, and interacting group decision making processes, Acad Manage J, 17, 605, 10.2307/255641

Fink, 1984, Consensus methods: characteristics and guidelines for use, Am J Public Health, 74, 979, 10.2105/AJPH.74.9.979

Ruperto, 2008, Consensus procedures and their role in pediatric rheumatology, Curr Rheumatol Rep, 10, 142, 10.1007/s11926-008-0025-6

Totikidis, 2010, Applying the Nominal Group Technique (NGT) in Community Based Action Research for Health Promotion and Disease Prevention, Aust Community Psychol, 22, 18

ARA Glossary Committee, 1982, Signs and symptoms [monograph], Vol I

ARA Glossary Committee, 1985, Diagnostic testing [monograph], Vol II

Efron, 1997, Improvements on cross-validation: the 632+ bootstrap method, J Am Stat Assoc, 92, 548

Hsiung, 2003, Multicentric reticulohistiocytosis presenting with clinical features of dermatomyositis, J Am Acad Dermatol, 48, S11, 10.1067/mjd.2003.126

Fett, 2011, Multicentric reticulohistiocytosis with dermatomyositis-like features: a more common disease presentation than previously thought, Dermatology, 222, 102, 10.1159/000323254

Aggarwal, 2015, Distinctions between diagnostic and classification criteria?, Arthritis Care Res, 67, 891, 10.1002/acr.22583

Casciola-Rosen, 2012, Myositis autoantibodies, Curr Opin Rheumatol, 24, 602, 10.1097/BOR.0b013e328358bd85

Lloyd, 2014, Evaluation and construction of diagnostic criteria for inclusion body myositis, Neurology, 83, 426, 10.1212/WNL.0000000000000642

Thông tin
Thông tin xuất bản

Annals of the Rheumatic Diseases

Tập 76 Số 12

1955-1964

Thông tin tác giả