1H magnetic resonance spectroscopy studies of cerebral metabolism in children

This article summarizes some applications of1H magnetic resonance spectroscopy in the investigation of children with brain disease. Studies are described of children with inborn errors of metabolism, including lactic acidoses and mitochondrial disorders, ornithine carbamoyl transferase deficiency (a disorder of the urea cycle), and Canavan's disease (a disorder of N-acetylaspartate metabolism). Applications in epilepsy are also discussed.