<scp>M</scp>aternal residential pesticide use and risk of childhood leukemia in <scp>C</scp>osta <scp>R</scp>ica

International Journal of Cancer - Tập 143 Số 6 - Trang 1295-1304 - 2018
Carly Hyland1,2, Robert B. Gunier1, Catherine Metayer3, Michael Bates4, Catharina Wesseling5, Ana M. Mora1,2
1Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California, Berkeley, CA
2Central American Institute for Studies on Toxic Substances (IRET), Universidad Nacional, Heredia, Costa Rica
3Division of Epidemiology, School of Public Health, University of California, Berkeley, CA
4Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA
5Department of Occupational Medicine, Institute of Environmental Medicine (IMM), Karolinska Institutet, Stockholm, Sweden

Tóm tắt

Evidence suggests that early‐life exposure to pesticides inside the home may be associated with childhood leukemia, however data from Latin American countries are limited. We examined whether self‐reported maternal residential pesticide use and nearby pesticide applications–before and after child's birth–were associated with acute lymphoblastic leukemia (ALL) in the Costa Rican Childhood Leukemia Study (CRCLS), a population‐based case‐control study (2001‐2003). Cases (n = 251 ALL) were diagnosed between 1995 and 2000 (age <15 years at diagnosis) and were identified through the Costa Rican Cancer Registry and National Children's Hospital. Population controls (n = 577) were drawn from the National Birth Registry. We fitted unconditional logistic regression models adjusted for child sex, birth year, and socioeconomic status to estimate the exposure‐outcome associations and also stratified by child sex. We observed that self‐reported maternal insecticide use inside the home in the year before pregnancy, during pregnancy, and while breastfeeding was associated with increased odds of ALL among boys [adjusted Odds Ratio (aOR) = 1.63 (95% confidence interval [95% CI]: 1.05–2.53), 1.75 (1.13–2.73), and 1.75 (1.12–2.73), respectively. We also found evidence of exposure‐response relationships between more frequent maternal insecticide use inside the home and increased odds of ALL among boys and girls combined. Maternal report of pesticide applications on farms or companies near the home during pregnancy and at any time period were also associated with ALL. Our study in Costa Rica highlights the need for education to minimize pesticide exposures inside and around the home, particularly during pregnancy and breastfeeding.

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International Journal of Cancer

Tập 143 Số 6

1295-1304

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