LSD1 inhibition induces differentiation and cell death in Merkel cell carcinoma

EMBO Molecular Medicine - Tập 12 Số 11 - 2020
Lukas Leiendecker1, Pauline S. Jung2,1, Izabela Kręcioch1, Tobias Neumann1, Alexander Schleiffer1, Karl Mechtler3, Thomas Wiesner2, Anna C. Obenauf1
1Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria
2Department of Dermatology, Medical University of Vienna, Vienna, Austria
3Institute of Molecular Biotechnology (IMBA) Vienna BioCenter (VBC) Vienna Austria

Tóm tắt

Từ khóa


Tài liệu tham khảo

10.1038/ncb2246

10.1093/nar/25.17.3389

10.1016/j.ccell.2019.09.005

10.1073/pnas.96.17.9873

10.1126/scisignal.aau2922

10.1016/j.cell.2005.03.013

10.1038/emboj.2013.110

10.1093/nar/gkr128

10.1021/acs.jmedchem.7b00306

10.1093/nar/30.4.1038

Cai SF, 2020, Leukemia cell of origin influences apoptotic priming and sensitivity to LSD1 inhibition, Cancer Discov

10.1073/pnas.1121522109

10.1016/j.neo.2018.10.003

Clark NA, 2017, GRcalculator: an online tool for calculating and mining dose‐response data, BMC Cancer, 17, 698, 10.1186/s12885-017-3689-3

10.1038/nmeth.4396

Crowley LC, 2016, Measuring mitochondrial transmembrane potential by TMRE staining, Cold Spring Harb Protoc, 2016, 1092, 10.1101/pdb.prot087361

10.1093/bioinformatics/bts635

Doblmann J, 2019, apQuant: accurate label‐free quantification by quality filtering, J Proteome Res, 18, 535

10.1021/pr500202e

10.1021/acsmedchemlett.5b00380

10.1016/j.celrep.2019.07.058

10.1093/nar/gky995

10.1038/s41587-020-0439-x

10.1186/s13045-019-0811-9

10.1016/j.celrep.2013.11.020

10.1126/science.1152586

10.1158/0008-5472.CAN-12-1739

10.1038/nature09504

10.1126/science.aal2380

10.1007/BF00191370

10.1038/nchembio.1859

10.1073/pnas.112008599

10.1158/0008-5472.CAN-15-0702

10.1038/s41571-018-0103-2

10.1073/pnas.1907154116

10.1016/j.ccr.2012.03.014

10.1007/978-1-4939-7493-1_17

10.1016/j.molcel.2010.05.004

10.1038/nmeth.4435

10.1128/JVI.02400-09

Huang ME, 1989, Use of all‐trans retinoic acid in the treatment of acute promyelocytic leukemia, Haematol Blood Transfus, 32, 88

10.1002/cam4.815

10.7554/eLife.42633

10.1038/nrg.2016.93

10.1038/s41467-017-02242-4

10.1038/nmeth1113

10.1093/bib/bbn013

10.1016/S1470-2045(16)30364-3

10.1016/j.gde.2017.03.015

KillianT GattoL(2019)Exploiting Depmap cancer dependency data using the depmap R package.https://zenodo.org/record/3565687

10.1073/pnas.0900604106

10.1177/2058460117700449

10.1016/j.molcel.2015.01.010

10.1093/bioinformatics/btp352

Li J, 2020, How tumor cell dedifferentiation drives immune evasion and resistance to immunotherapy, Cancer Res

10.1186/s13059-014-0550-8

10.1126/science.1076469

10.1126/science.252.5009.1162

10.1016/j.ccell.2018.02.002

10.1016/j.celrep.2018.03.012

10.7554/eLife.46314

10.1101/cshperspect.a022244

10.1016/j.ccell.2015.06.002

10.1016/0092-8674(91)90019-U

10.1126/science.aao2793

10.1093/nar/gkr793

Neumann T, 2019, Quantification of experimentally induced nucleotide conversions in high‐throughput sequencing datasets, BMC Bioinformatics, 20, 258, 10.1186/s12859-019-2849-7

10.1056/NEJMoa1603702

Ostrowski SM, 2015, Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis, Development, 142, 2533

10.1038/s41556-020-0503-2

10.15252/embj.201591206

PatelH EwelsP PeltzerA(2019)nf‐core/atacseq: nf-core/atacseq v1.1.0 ‐ Iron Shark.https://zenodo.org/record/3529420

10.1038/nbt.3807

10.1242/dev.112169

10.1038/nmeth.2639

10.1093/nar/gkw257

10.1093/nar/gkz369

10.1111/cup.13079

10.1016/j.molcel.2007.06.039

10.1038/nm.2661

10.1073/pnas.1719168115

10.1016/j.cell.2013.03.008

10.1016/j.cell.2018.05.052

10.1007/0-387-29362-0_23

10.1182/blood.V128.22.4060.4060

10.1093/bioinformatics/btz009

10.1073/pnas.0506580102

10.1159/000015486

10.1200/JCO.2000.18.12.2493

10.1056/NEJM199710093371501

10.1021/pr200611n

10.1016/j.cell.2017.06.010

Verzé L, 2003, Distribution of GAP‐43 nerve fibers in the skin of the adult human hand: GAP‐43 Nerve Fibers in Human Hand Skin, Anat Rec, 272, 467, 10.1002/ar.a.10056

10.1038/nature05671

WangC EwelsP PatelH PeltzerA SilvaTC KretzschmarW HaglundS;Rotholandus(2019)nf‐core/chipseq: nf‐core/chipseq v1.1.0 ‐ Platinum Pig.https://zenodo.org/record/3529400

10.1093/bioinformatics/btp033

WickhamH(2016)ggplot2: Elegant Graphics for Data Analysis.https://ggplot2.tidyverse.org

10.1038/s41467-019-09234-6