<i>p63</i>in Epithelial Survival, Germ Cell Surveillance, and Neoplasia

Annual Review of Pathology: Mechanisms of Disease - Tập 5 Số 1 - Trang 349-371 - 2010
Christopher P. Crum1, Frank McKeon2
1Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, 02115
2Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, 02115

Tóm tắt

The p53homolog p63has emerged as a gene with an enormously complex function that is distinct from that of p53. It encodes two distinct transcript isoforms that have a dramatic impact on replenishment of cutaneous epithelial stem cells and on ovarian germ cell survival. However, although these two fundamental roles of p63 attest to its powerful place in development, its other functions—specifically the apparent capacity of p63, when induced, to supervise the emergence of new cell populations in the breast, prostate, cervix, and upper reproductive tract—are shared by embryo and adult. These observed functions may only scratch the surface of a repertoire that has been postulated to encompass a range of cellular activities, as evidenced by the fact that p63 proteins have been shown to potentially bind to over 5800 target sites. Whether tumorigenic pathways are also involved, and to what extent, is a subject of both promise and controversy that remains to be resolved.

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Annual Review of Pathology: Mechanisms of Disease

Tập 5 Số 1

349-371

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