Coustan-Smith, 2009, Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia, Lancet Oncol, 10, 147, 10.1016/S1470-2045(08)70314-0
Zhang, 2012, The genetic basis of early T-cell precursor acute lymphoblastic leukaemia, Nature, 481, 157, 10.1038/nature10725
Malumbres, 2003, RAS oncogenes: the first 30 years, Nat Rev Cancer, 3, 459, 10.1038/nrc1097
Bos, 2007, GEFs and GAPs: critical elements in the control of small G proteins, Cell, 129, 865, 10.1016/j.cell.2007.05.018
Vigil, 2010, Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?, Nat Rev Cancer, 10, 842, 10.1038/nrc2960
Ksionda, 2013, RasGRP Ras guanine nucleotide exchange factors in cancer, Front Biol (Beijing), 8, 508, 10.1007/s11515-013-1276-9
Jun, 2013, Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS, Mol Cell Biol, 33, 2470, 10.1128/MCB.01593-12
Margarit, 2003, Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS, Cell, 112, 685, 10.1016/S0092-8674(03)00149-1
Das, 2009, Digital signaling and hysteresis characterize ras activation in lymphoid cells, Cell, 136, 337, 10.1016/j.cell.2008.11.051
Iversen, 2014, Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics, Science, 345, 50, 10.1126/science.1250373
Christensen, 2016, One-way membrane trafficking of SOS in receptor-triggered Ras activation, Nat Struct Mol Biol, 23, 838, 10.1038/nsmb.3275
Boykevisch, 2006, Regulation of ras signaling dynamics by Sos-mediated positive feedback, Curr Biol, 16, 2173, 10.1016/j.cub.2006.09.033
Jeng, 2012, Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis, Nat Commun, 3, 1168, 10.1038/ncomms2173
Depeille, 2015, RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth, Nat Cell Biol, 17, 804, 10.1038/ncb3175
You, 2018, Unique dependence on Sos1 in KrasG12D -induced leukemogenesis, Blood, 132, 2575, 10.1182/blood-2018-09-874107
Kortum, 2011, Targeted Sos1 deletion reveals its critical role in early T-cell development, Proc Natl Acad Sci USA, 108, 12407, 10.1073/pnas.1104295108
Iwig, 2013, Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1, eLife, 2, e00813, 10.7554/eLife.00813
Roose, 2007, Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes, Mol Cell Biol, 27, 2732, 10.1128/MCB.01882-06
Hartzell, 2013, Dysregulated RasGRP1 responds to cytokine receptor input in T cell leukemogenesis, Sci Signal, 6, ra21, 10.1126/scisignal.2003848
Ksionda, 2016, RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines, Oncogene, 35, 3658, 10.1038/onc.2015.431
Klinger, 2005, Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors, Oncogene, 24, 2695, 10.1038/sj.onc.1208334
Norment, 2003, Transgenic expression of RasGRP1 induces the maturation of double-negative thymocytes and enhances the production of CD8 single-positive thymocytes, J Immunol, 170, 1141, 10.4049/jimmunol.170.3.1141
Oki, 2012, Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis, Leukemia, 26, 1038, 10.1038/leu.2011.328
Dower, 2000, RasGRP is essential for mouse thymocyte differentiation and TCR signaling, Nat Immunol, 1, 317, 10.1038/79766
Ward, 2012, Targeting oncogenic Ras signaling in hematologic malignancies, Blood, 120, 3397, 10.1182/blood-2012-05-378596
Schubbert, 2007, Hyperactive Ras in developmental disorders and cancer, Nat Rev Cancer, 7, 295, 10.1038/nrc2109
Bowen, 2005, RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years, Blood, 106, 2113, 10.1182/blood-2005-03-0867
Wang, 2010, Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia, Blood, 116, 5991, 10.1182/blood-2010-04-281527
Li, 2011, Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus, Blood, 117, 2022, 10.1182/blood-2010-04-280750
Kong, 2016, The ability of endogenous Nras oncogenes to initiate leukemia is codon-dependent, Leukemia, 30, 1935, 10.1038/leu.2016.89
Damnernsawad, 2016, Kras is required for adult hematopoiesis, Stem Cells, 34, 1859, 10.1002/stem.2355
Burd, 2014, Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma, Cancer Discov, 4, 1418, 10.1158/2159-8290.CD-14-0729
Hennessey, 2017, Ultraviolet radiation accelerates NRas-mutant melanomagenesis: a cooperative effect blocked by sunscreen, Pigment Cell Melanoma Res, 30, 477, 10.1111/pcmr.12601
Liu, 2017, The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia, Nat Genet, 49, 1211, 10.1038/ng.3909
Du, 2013, Loss of CD44 attenuates aberrant GM-CSF signaling in Kras G12D hematopoietic progenitor/precursor cells and prolongs the survival of diseased animals, Leukemia, 27, 754, 10.1038/leu.2012.251
Chang, 2015, Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis, Leukemia, 29, 1847, 10.1038/leu.2015.85
Yui, 2014, Developmental gene networks: a triathlon on the course to T cell identity, Nat Rev Immunol, 14, 529, 10.1038/nri3702
Booth, 2018, Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors, Cancer Cell, 33, 274, 10.1016/j.ccell.2018.01.006
Shortman, 1996, Early T lymphocyte progenitors, Annu Rev Immunol, 14, 29, 10.1146/annurev.immunol.14.1.29
Johnson, 1997, K-ras is an essential gene in the mouse with partial functional overlap with N-ras, Genes Dev, 11, 2468, 10.1101/gad.11.19.2468
Wang, 2018, Ezh2 loss propagates hypermethylation at T cell differentiation-regulating genes to promote leukemic transformation, J Clin Invest, 128, 3872, 10.1172/JCI94645
Dik, 2005, New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling, J Exp Med, 201, 1715, 10.1084/jem.20042524
Chen, 2016, Kras is critical for B cell lymphopoiesis, J Immunol, 196, 1678, 10.4049/jimmunol.1502112
Franceschini, 2013, STRING v9.1: protein-protein interaction networks, with increased coverage and integration, Nucleic Acids Res, 41, D808
Kong, 2014, Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm, J Clin Invest, 124, 2762, 10.1172/JCI74182
Saelee, 2017, Genome-wide identification of target genes for the key B cell transcription factor Ets1, Front Immunol, 8, 383, 10.3389/fimmu.2017.00383
Daley, 2013, Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies, eLife, 2, e01020, 10.7554/eLife.01020
Pérez de Castro, 2003, Mice deficient for N-ras: impaired antiviral immune response and T-cell function, Cancer Res, 63, 1615
Luo, 2020, Kras-deficient T cells attenuate graft-versus-host disease but retain graft-versus-leukemia activity, J Immunol, 205, 3480, 10.4049/jimmunol.2000006
Bremner, 1990, Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7, Cell, 61, 407, 10.1016/0092-8674(90)90523-H
Buchmann, 1991, Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7, Cancer Res, 51, 4097
Zhang, 2001, Wildtype Kras2 can inhibit lung carcinogenesis in mice, Nat Genet, 29, 25, 10.1038/ng721
Puyol, 2010, A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma, Cancer Cell, 18, 63, 10.1016/j.ccr.2010.05.025
Kong, 2016, Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis, Leukemia, 30, 1542, 10.1038/leu.2016.40
Chang, 2017, The mystery of oncogenic KRAS: Lessons from studying its wild-type counter part, Small GTPases, 8, 233, 10.1080/21541248.2016.1215656
Kortum, 2012, Deconstructing Ras signaling in the thymus, Mol Cell Biol, 32, 2748, 10.1128/MCB.00317-12
Priatel, 2002, RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation, Immunity, 17, 617, 10.1016/S1074-7613(02)00451-X
Eyquem, 2004, The Ets-1 transcription factor is required for complete pre-T cell receptor function and allelic exclusion at the T cell receptor beta locus, Proc Natl Acad Sci USA, 101, 15712, 10.1073/pnas.0405546101
Lauchle, 2009, Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras, Nature, 461, 411, 10.1038/nature08279