Khuếch đại MET dẫn đến kháng Gefitinib trong ung thư phổi thông qua kích hoạt tín hiệu ERBB3
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#EGFR #Gefitinib #Erlotinib #MET khuếch đại #kháng thuốc #ung thư phổi #tín hiệu ERBB3 #ERBB3 (HER3) #PI3K #các thụ thể họ EGFR/ERBB.Tài liệu tham khảo
Materials and methods are available as supporting material on Science Online.
J. G. Christensen et al., Cancer Res.63, 7345 (2003).
F. M. Yakes et al., Cancer Res.62, 4132 (2002).
We thank M. Begley for providing the lentiviral expression vector E. Fox for MET sequencing and K. Cichowski and D. E. Fisher for helpful discussions. This work was supported by grants from the National Institutes of Health 1K12CA87723-01 (P.A.J.) RO1CA114465-01 (B.E.J. and P.A.J.) RO1-CA111560 (C.L.) NIH GM41890 (L.C.C.) and PO1 CA089021 (L.C.C.) the National Cancer Institute K08CA120060-01 (J.A.E.) the National Cancer Institute Lung SPORE P20CA90578-02 (B.E.J.) the American Cancer Society RSG-06-102-01 (P.A.J. and J.A.E.) and by the American Association for Cancer Research the International Association for the Study of Lung Cancer (J.A.E.) and the Italian Association for Cancer Research (F.C.). P.A.J. and B.E.J. are part of a pending patent application on EGFR mutations.