Luisa Cervantes‐Barragán1, Jiani Chai2,1, Ma. Diarey B. Tianero3, Blanda Di Luccia1, Philip P. Ahern4,5, Joseph A. Merriman6, Victor S. Cortez1, Michael G. Caparon6, Mohamed S. Donia3, Susan Gilfillan1, Marina Cella1, Jeffrey I. Gordon4,5, Chyi‐Song Hsieh2,1, Marco Colonna1
1Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
2Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA
3Department of Molecular Biology, Princeton University, Princeton, NJ 08544 USA
4Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO 63110, USA
5Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO 63110, USA
6Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Tóm tắt
Tolerogenic T cells need probiotics
CD4
+
CD8αα
+
double-positive intraepithelial lymphocytes (DP IELs) are a recently discovered class of intestinal T cells believed to take part in a variety of immune responses, including oral tolerance. These cells are absent in germ-free mice, but the mechanisms driving their development are unclear. Cervantes-Barragan
et al.
found that a particular species of probiotic bacteria,
Lactobacillus reuteri
, induces DP IELs. This does not occur by stimulating the immune system directly. Instead,
L. reuteri
generates a specific derivative of dietary tryptophan that promotes differentiation of DP IEL precursors. These findings underscore the delicate interplay between benign bacteria, diet, and gut health.
Science
, this issue p.
806
